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- W4366708049 abstract "Background One of the most prevalent gynaecological cancers in developed nations is Endometrial Carcinoma. Endometrial hyperplasia, Atypical Endometrial Hyperplasia and nally fully developed, well-differentiated Adenocarcinoma are regarded to be the progression of premalignant lesions into Endometrial Carcinoma. The p53 signalling pathways are crucial in the development of Endometrial Cancer. Expression of p53 is associated with Atypical Endometrial Hyperplasia and Endometrial Carcinomas. T Aim & Objective o study the expression of p53 as molecular biomarker in Normal, hyperplastic and neoplastic lesions of endometrium. Material & Methods A total of 50 cases of endometrial biopsies were collected over a period of 18 months from January 2020 to June 2021. Samples were received and reported in Department of Pathology Gandhi Medical College, Bhopal, Madhya Pradesh. A total of 50 cases of e Results ndometrial lesion were studied. p53 expression was observed in 80% cases of the Endometrial Carcinoma and 50% cases of Atypical Endometrial Hyperplasia. It was mostly negative in Normal and Endometrial Hyperplasia. Expression of p53 in Atypical Endometrial Hyperplasia and Endometrial Carcinomas helps to detect the progression and predicting the response to targeted therapies against carcinogenic pathways. Conclusion p53 expression is mainly seen in Endometrial Cancer and Atypical Endometrial Hyperplasia. And it is almost absent in Normal and Endometrial Hyperplasia. The dysregulation appears to be most evident in the Atypical Endometrial Hyperplasia. This expression pattern suggests that p53 over-expression could be the origin of endometrial cancer" @default.
- W4366708049 created "2023-04-24" @default.
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- W4366708049 date "1999-03-01" @default.
- W4366708049 modified "2023-10-18" @default.
- W4366708049 title "EXPRESSION OF P53 IN NORMAL, HYPERPLASTIC AND NEOPLASTIC LESIONS OF ENDOMETRIUM" @default.
- W4366708049 doi "https://doi.org/10.36106/ijsr/3612028" @default.
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