Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366716680> ?p ?o ?g. }
- W4366716680 abstract "Abstract Since its introduction by Cravatt and colleagues in 1999, activity‐based protein profiling (ABPP) has become widely utilized throughout academia, government, and industry laboratories to study enzymes spanning numerous gene families in a multitude of biological systems. As a variation of ABPP, competitive ABPP provides a powerful approach to characterize the binding behavior of small molecule probes and clinical drugs throughout the functional proteome. The power and flexibility of competitive ABPP are exemplified by a wide range of creative adaptions which increase assay throughput, enable diverse detection schemes, and support the implementation of this approach within a hybrid target‐based screening platform. We review major developments in competitive ABPP through a compare‐contrast format to provide a useful introduction to this enabling technology for scientists in chemical biology and drug discovery." @default.
- W4366716680 created "2023-04-24" @default.
- W4366716680 creator A5004031054 @default.
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- W4366716680 creator A5027584754 @default.
- W4366716680 creator A5074563113 @default.
- W4366716680 creator A5091846179 @default.
- W4366716680 date "2023-03-01" @default.
- W4366716680 modified "2023-10-15" @default.
- W4366716680 title "Strategies for Competitive Activity‐Based Protein Profiling in Small Molecule Inhibitor Discovery and Characterization" @default.
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