FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366750880> ?p ?o ?g. }

• W4366750880 abstract "The ability to inhibit aggregation has been demonstrated with synthetically derived ginsenoside compounds G-Rp (1, 3, and 4) and ginsenosides naturally found in Panax ginseng 20(S)-Rg3, Rg6, F4, and Ro. Among these compounds, Rk3 (G-Rk3) from Panax ginseng needs to be further explored in order to reveal the mechanisms of action during inhibition. Our study focused to investigate the action of G-Rk3 on agonist-stimulated human platelet aggregation, inhibition of platelet signaling molecules such as fibrinogen binding with integrin αIIbβ3 using flow cytometry, intracellular calcium mobilization, dense granule secretion, and thromboxane B2 secretion. In addition, we checked the regulation of phosphorylation on PI3K/MAPK pathway, and thrombin-induced clot retraction was also observed in platelets rich plasma. G-Rk3 significantly increased amounts of cyclic adenosine monophosphate (cAMP) and led to significant phosphorylation of cAMP-dependent kinase substrates vasodilator-stimulated phosphoprotein (VASP) and inositol 1,4,5-trisphosphate receptor (IP3R). In the presence of G-Rk3, dense tubular system Ca2+ was inhibited, and platelet activity was lowered by inactivating the integrin αIIb/β3 and reducing the binding of fibrinogen. Furthermore, the effect of G-Rk3 extended to the inhibition of MAPK and PI3K/Akt phosphorylation resulting in the reduced secretion of intracellular granules and reduced production of TXA2. Lastly, G-Rk3 inhibited platelet aggregation and thrombus formation via fibrin clot. These results suggest that when dealing with cardiovascular diseases brought upon by faulty aggregation among platelets or through the formation of a thrombus, the G-Rk3 compound can play a role as an effective prophylactic or therapeutic agent." @default.
• W4366750880 created "2023-04-24" @default.
• W4366750880 creator A5002299840 @default.
• W4366750880 creator A5007990347 @default.
• W4366750880 creator A5014986711 @default.
• W4366750880 creator A5048938308 @default.
• W4366750880 creator A5063581711 @default.
• W4366750880 date "2023-04-01" @default.
• W4366750880 modified "2023-09-25" @default.
• W4366750880 title "Anti-thrombotic effects of ginsenoside Rk3 by regulating cAMP and PI3K/MAPK pathway on human platelets" @default.
• W4366750880 cites W1481290542 @default.
• W4366750880 cites W1881172791 @default.
• W4366750880 cites W1971648429 @default.
• W4366750880 cites W1990946341 @default.
• W4366750880 cites W1996385909 @default.
• W4366750880 cites W1997093700 @default.
• W4366750880 cites W2012040337 @default.
• W4366750880 cites W2018307163 @default.
• W4366750880 cites W2041183642 @default.
• W4366750880 cites W2042180990 @default.
• W4366750880 cites W2046589593 @default.
• W4366750880 cites W2052764119 @default.
• W4366750880 cites W2059773168 @default.
• W4366750880 cites W2069651362 @default.
• W4366750880 cites W2076690965 @default.
• W4366750880 cites W2084264412 @default.
• W4366750880 cites W2086948789 @default.
• W4366750880 cites W2091287127 @default.
• W4366750880 cites W2100520512 @default.
• W4366750880 cites W2108349218 @default.
• W4366750880 cites W2116551664 @default.
• W4366750880 cites W2133784539 @default.
• W4366750880 cites W2141260882 @default.
• W4366750880 cites W2147706892 @default.
• W4366750880 cites W2158070111 @default.
• W4366750880 cites W2160459388 @default.
• W4366750880 cites W2165352005 @default.
• W4366750880 cites W2166000498 @default.
• W4366750880 cites W2169682585 @default.
• W4366750880 cites W2324705707 @default.
• W4366750880 cites W2750967286 @default.
• W4366750880 cites W2783501669 @default.
• W4366750880 cites W2805752594 @default.
• W4366750880 cites W2920655114 @default.
• W4366750880 cites W3026687471 @default.
• W4366750880 cites W3090679182 @default.
• W4366750880 cites W3103501536 @default.
• W4366750880 cites W4211059837 @default.
• W4366750880 cites W56507834 @default.
• W4366750880 doi "https://doi.org/10.1016/j.jgr.2023.04.006" @default.
• W4366750880 hasPublicationYear "2023" @default.
• W4366750880 type Work @default.
• W4366750880 citedByCount "0" @default.
• W4366750880 crossrefType "journal-article" @default.
• W4366750880 hasAuthorship W4366750880A5002299840 @default.
• W4366750880 hasAuthorship W4366750880A5007990347 @default.
• W4366750880 hasAuthorship W4366750880A5014986711 @default.
• W4366750880 hasAuthorship W4366750880A5048938308 @default.
• W4366750880 hasAuthorship W4366750880A5063581711 @default.
• W4366750880 hasBestOaLocation W43667508801 @default.
• W4366750880 hasConcept C11960822 @default.
• W4366750880 hasConcept C126322002 @default.
• W4366750880 hasConcept C142724271 @default.
• W4366750880 hasConcept C170493617 @default.
• W4366750880 hasConcept C185592680 @default.
• W4366750880 hasConcept C204787440 @default.
• W4366750880 hasConcept C2776668983 @default.
• W4366750880 hasConcept C2777292125 @default.
• W4366750880 hasConcept C2778863912 @default.
• W4366750880 hasConcept C2779232237 @default.
• W4366750880 hasConcept C3018697912 @default.
• W4366750880 hasConcept C55493867 @default.
• W4366750880 hasConcept C71924100 @default.
• W4366750880 hasConcept C86803240 @default.
• W4366750880 hasConcept C89560881 @default.
• W4366750880 hasConcept C95444343 @default.
• W4366750880 hasConcept C97029542 @default.
• W4366750880 hasConcept C98274493 @default.
• W4366750880 hasConceptScore W4366750880C11960822 @default.
• W4366750880 hasConceptScore W4366750880C126322002 @default.
• W4366750880 hasConceptScore W4366750880C142724271 @default.
• W4366750880 hasConceptScore W4366750880C170493617 @default.
• W4366750880 hasConceptScore W4366750880C185592680 @default.
• W4366750880 hasConceptScore W4366750880C204787440 @default.
• W4366750880 hasConceptScore W4366750880C2776668983 @default.
• W4366750880 hasConceptScore W4366750880C2777292125 @default.
• W4366750880 hasConceptScore W4366750880C2778863912 @default.
• W4366750880 hasConceptScore W4366750880C2779232237 @default.
• W4366750880 hasConceptScore W4366750880C3018697912 @default.
• W4366750880 hasConceptScore W4366750880C55493867 @default.
• W4366750880 hasConceptScore W4366750880C71924100 @default.
• W4366750880 hasConceptScore W4366750880C86803240 @default.
• W4366750880 hasConceptScore W4366750880C89560881 @default.
• W4366750880 hasConceptScore W4366750880C95444343 @default.
• W4366750880 hasConceptScore W4366750880C97029542 @default.
• W4366750880 hasConceptScore W4366750880C98274493 @default.
• W4366750880 hasLocation W43667508801 @default.
• W4366750880 hasOpenAccess W4366750880 @default.
• W4366750880 hasPrimaryLocation W43667508801 @default.
• W4366750880 hasRelatedWork W1964894777 @default.

• next