Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366753692> ?p ?o ?g. }
- W4366753692 endingPage "106719" @default.
- W4366753692 startingPage "106719" @default.
- W4366753692 abstract "Epithelial ovarian cancer (OC) is often diagnosed at an advanced stage with peritoneal metastasis, and preclinical models mimicking the natural course of OC peritoneal metastasis are essential to improve treatment. We implanted ES2 and ID8 cells in the ovaries of mice and obtained highly metastatic (HM) sublines from their omental metastases after three cycles in vivo selection. Orthotopic xenografts derived from the HM sublines showed enhanced omental tropism and more extensive metastasis with earlier onset. The HM cells exhibited increased in vitro migration and invasion properties, and RNA sequencing revealed that the genes related to epithelial-mesenchymal transition and extracellular matrix regulation were significantly altered in the HM cells. Among them, the upregulated genes were significantly associated with poorer survival in OC patients. In conclusion, these HM sublines can be leveraged to establish spontaneous metastatic OC mouse models, which may serve as ideal preclinical models for anti-metastasis therapy for OC patients." @default.
- W4366753692 created "2023-04-24" @default.
- W4366753692 creator A5009235748 @default.
- W4366753692 creator A5033447038 @default.
- W4366753692 creator A5047726315 @default.
- W4366753692 creator A5048898414 @default.
- W4366753692 creator A5049166738 @default.
- W4366753692 creator A5079650655 @default.
- W4366753692 creator A5085313043 @default.
- W4366753692 date "2023-05-01" @default.
- W4366753692 modified "2023-10-14" @default.
- W4366753692 title "Establishment of highly metastatic ovarian cancer model with omental tropism via in vivo selection" @default.
- W4366753692 cites W1518520618 @default.
- W4366753692 cites W1963501822 @default.
- W4366753692 cites W1976006503 @default.
- W4366753692 cites W1985727076 @default.
- W4366753692 cites W1997338647 @default.
- W4366753692 cites W2000269194 @default.
- W4366753692 cites W2032496195 @default.
- W4366753692 cites W2038720503 @default.
- W4366753692 cites W2042633087 @default.
- W4366753692 cites W2062249523 @default.
- W4366753692 cites W2082668371 @default.
- W4366753692 cites W2086190192 @default.
- W4366753692 cites W2123106337 @default.
- W4366753692 cites W2130410032 @default.
- W4366753692 cites W2142008541 @default.
- W4366753692 cites W2147772438 @default.
- W4366753692 cites W2419582720 @default.
- W4366753692 cites W2438866487 @default.
- W4366753692 cites W2557222435 @default.
- W4366753692 cites W2586407709 @default.
- W4366753692 cites W2625196826 @default.
- W4366753692 cites W2752907448 @default.
- W4366753692 cites W2811356741 @default.
- W4366753692 cites W2885723242 @default.
- W4366753692 cites W2900850487 @default.
- W4366753692 cites W2906067435 @default.
- W4366753692 cites W2945357020 @default.
- W4366753692 cites W2951605527 @default.
- W4366753692 cites W2970819265 @default.
- W4366753692 cites W3006464663 @default.
- W4366753692 cites W3014142960 @default.
- W4366753692 cites W3016947839 @default.
- W4366753692 cites W3099043519 @default.
- W4366753692 cites W3126651823 @default.
- W4366753692 cites W3131573387 @default.
- W4366753692 cites W3132083016 @default.
- W4366753692 cites W3136256872 @default.
- W4366753692 cites W3153473864 @default.
- W4366753692 cites W3156577277 @default.
- W4366753692 cites W3169849224 @default.
- W4366753692 cites W3177399469 @default.
- W4366753692 cites W3194665116 @default.
- W4366753692 cites W3206402442 @default.
- W4366753692 cites W3211014030 @default.
- W4366753692 cites W4315754639 @default.
- W4366753692 doi "https://doi.org/10.1016/j.isci.2023.106719" @default.
- W4366753692 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37197325" @default.
- W4366753692 hasPublicationYear "2023" @default.
- W4366753692 type Work @default.
- W4366753692 citedByCount "0" @default.
- W4366753692 crossrefType "journal-article" @default.
- W4366753692 hasAuthorship W4366753692A5009235748 @default.
- W4366753692 hasAuthorship W4366753692A5033447038 @default.
- W4366753692 hasAuthorship W4366753692A5047726315 @default.
- W4366753692 hasAuthorship W4366753692A5048898414 @default.
- W4366753692 hasAuthorship W4366753692A5049166738 @default.
- W4366753692 hasAuthorship W4366753692A5079650655 @default.
- W4366753692 hasAuthorship W4366753692A5085313043 @default.
- W4366753692 hasBestOaLocation W43667536921 @default.
- W4366753692 hasConcept C121608353 @default.
- W4366753692 hasConcept C126322002 @default.
- W4366753692 hasConcept C142724271 @default.
- W4366753692 hasConcept C150903083 @default.
- W4366753692 hasConcept C189165786 @default.
- W4366753692 hasConcept C202751555 @default.
- W4366753692 hasConcept C203014093 @default.
- W4366753692 hasConcept C207001950 @default.
- W4366753692 hasConcept C2522874641 @default.
- W4366753692 hasConcept C2779013556 @default.
- W4366753692 hasConcept C2780427987 @default.
- W4366753692 hasConcept C35693153 @default.
- W4366753692 hasConcept C502942594 @default.
- W4366753692 hasConcept C55493867 @default.
- W4366753692 hasConcept C71924100 @default.
- W4366753692 hasConcept C76419328 @default.
- W4366753692 hasConcept C86803240 @default.
- W4366753692 hasConcept C95444343 @default.
- W4366753692 hasConceptScore W4366753692C121608353 @default.
- W4366753692 hasConceptScore W4366753692C126322002 @default.
- W4366753692 hasConceptScore W4366753692C142724271 @default.
- W4366753692 hasConceptScore W4366753692C150903083 @default.
- W4366753692 hasConceptScore W4366753692C189165786 @default.
- W4366753692 hasConceptScore W4366753692C202751555 @default.
- W4366753692 hasConceptScore W4366753692C203014093 @default.
- W4366753692 hasConceptScore W4366753692C207001950 @default.
- W4366753692 hasConceptScore W4366753692C2522874641 @default.