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- W4366754839 endingPage "372" @default.
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- W4366754839 abstract "Differences in transcriptomes, transcription factor usage, and function have identified T follicular helper 2 (Tfh2) cells and T helper 2 (Th2) cells as distinct clusters of differentiation 4+,(CD4) T-cell subsets in settings of type-2 inflammation. Although the transcriptional programs driving Th2 cell differentiation and cytokine production are well defined, dependence on these classical Th2 programs by Tfh2 cells is less clear. Using cytokine reporter mice in combination with transcription factor inference analysis, the b-Zip transcription factor c-Maf and its targets were identified as an important regulon in both Th2 and Tfh2 cells. Conditional deletion of c-Maf in T cells confirmed its importance in type-2 cytokine expression by Th2 and Tfh2 cells. However, while c-Maf was not required for Th2-driven helminth clearance or lung eosinophilia, it was required for Tfh2-driven Immunoglobulin E production and germinal center formation. This differential regulation of cell-mediated and humoral immunity by c-Maf was a result of redundant pathways in Th2 cells that were absent in Tfh2 cells, and c-Maf-specific mechanisms in Tfh2 cells that were absent in Th2 cells. Thus, despite shared expression by Tfh2 and Th2 cells, c-Maf serves as a unique regulator of Tfh2-driven humoral hallmarks during type-2 immunity." @default.
- W4366754839 created "2023-04-24" @default.
- W4366754839 creator A5005988117 @default.
- W4366754839 creator A5010448332 @default.
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- W4366754839 creator A5067936584 @default.
- W4366754839 creator A5076148797 @default.
- W4366754839 creator A5088924293 @default.
- W4366754839 date "2023-06-01" @default.
- W4366754839 modified "2023-10-14" @default.
- W4366754839 title "A bifurcated role for c-Maf in Th2 and Tfh2 cells during helminth infection" @default.
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