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• W4366757425 abstract "AbstractFluoroquinolones (FQ) has been used after allogeneic hematopoietic stem cell transplantation (allo-HCT) for decades. This study on 284 allo-HCT recipients aimed to analyze the impact of FQ on pre-engraftment BSI. A total of 154 patients were colonized with resistant gram-negative bacteria, and 130 patients were not. Colonized patients did not receive FQ (n = 147) except 7 who received FQ as sequential therapy; 98 non-colonized patients received FQ, whereas 32 did not. Gram-negative (p < 0.0001), and ESBL-E BSI (p < 0.0001) were higher in colonized patients receiving FQ. No difference was found in gram-positive BSI (p = 0.452). In multivariate analysis colonized patients with (p < 0.0001) or without FQ (p = 0.007), omission of FQ in non-colonized patients (p = 0.038), and active disease (p = 0.042) were associated with gram-negative BSI, whereas mismatched unrelated donor transplantations - with gram-positive BSI (p = 0.009). Colonized patients with FQ have a higher risk of gram-negative BSI. In non-colonized patients, FQ prophylaxis is effective approach significantly reducing gram-negative BSI risk.Keywords: Allogeneic hematopoietic cell transplantation (allo-HCT)bloodstream infections (BSI)colonizationfluoroquinolone (FQ)pre-engraftment Author contributionsMA, GK, and EP contributed to the conception and design of the study; MA, KL, DM, FA obtained and analyzed the data; MA, GK, and EP contributed to the interpretation of data; MA drafted the manuscript; GK and EP critically revised the manuscript; all authors approved the final version of the manuscript.Disclosure statementNo potential conflict of interest was reported by the author(s).Data availability statementThe datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.Additional informationFundingThe author(s) reported there is no funding associated with the work featured in this article." @default.
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• W4366757425 date "2023-04-22" @default.
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• W4366757425 title "Impact of fluoroquinolone administration and gut mucosal colonization on the risk of pre-engraftment bloodstream infections after allogeneic hematopoietic cell transplantation" @default.
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• W4366757425 doi "https://doi.org/10.1080/10428194.2023.2197532" @default.
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