FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366768202> ?p ?o ?g. }

• W4366768202 abstract "Abstract Background Hypoxia is a hallmark of solid tumors and leads to the metabolic reprogramming of cancer cells. The role of epigenetic regulation between hypoxia and aberrant cholesterol metabolism in colorectal cancer (CRC) remains elusive. Methods Hypoxia-responsive circular RNAs (circRNAs) were identified by high throughput RNA sequencing between CRC cells cultured under normoxia or hypoxia. The protein-coding potential of circINSIG1 was identified by polysome profiling and LC–MS. The function of circINSIG1 was validated in vitro and in vivo by gain or loss of function assays. Mechanistic results were concluded by immunoprecipitation analyses. Results A novel hypoxia-responsive circRNA named circINSIG1 was identified, which was upregulated in CRC tissues and correlated with advanced clinical stages and poor survival. Mechanistically, circINSIG1 encoded a 121 amino acid protein circINSIG1-121 to promote K48-linked ubiquitination of the critical cholesterol metabolism regulator INSIG1 at lysine 156 and 158 by recruiting CUL5-ASB6 complex, a ubiquitin E3 ligase complex, thereby inducing cholesterol biosynthesis to promote CRC proliferation and metastasis. The orthotopic xenograft tumor models and patient-derived xenograft models further identified the role of circINSIG1 in CRC progression and potential therapeutic target of CRC. Conclusions circINSIG1 presents an epigenetic mechanism which provides insights into the crosstalk between hypoxia and cholesterol metabolism, and provides a promising therapeutic target for the treatment of CRC." @default.
• W4366768202 created "2023-04-25" @default.
• W4366768202 creator A5004370633 @default.
• W4366768202 creator A5006859983 @default.
• W4366768202 creator A5012934231 @default.
• W4366768202 creator A5024286539 @default.
• W4366768202 creator A5033350250 @default.
• W4366768202 creator A5037018453 @default.
• W4366768202 creator A5043888756 @default.
• W4366768202 creator A5044265859 @default.
• W4366768202 creator A5049453966 @default.
• W4366768202 creator A5071498928 @default.
• W4366768202 creator A5079233449 @default.
• W4366768202 creator A5089642545 @default.
• W4366768202 date "2023-04-22" @default.
• W4366768202 modified "2023-10-17" @default.
• W4366768202 title "A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer" @default.
• W4366768202 cites W1866220599 @default.
• W4366768202 cites W1985352530 @default.
• W4366768202 cites W1989792740 @default.
• W4366768202 cites W2039999119 @default.
• W4366768202 cites W2057518766 @default.
• W4366768202 cites W2057680047 @default.
• W4366768202 cites W2078794317 @default.
• W4366768202 cites W2097632838 @default.
• W4366768202 cites W2115420718 @default.
• W4366768202 cites W2130820087 @default.
• W4366768202 cites W2132719707 @default.
• W4366768202 cites W2137465719 @default.
• W4366768202 cites W2146544786 @default.
• W4366768202 cites W2149360266 @default.
• W4366768202 cites W2159728029 @default.
• W4366768202 cites W2523687917 @default.
• W4366768202 cites W2752390584 @default.
• W4366768202 cites W2792494514 @default.
• W4366768202 cites W2889646458 @default.
• W4366768202 cites W2902013383 @default.
• W4366768202 cites W2919736532 @default.
• W4366768202 cites W2944031662 @default.
• W4366768202 cites W2987284967 @default.
• W4366768202 cites W2994268592 @default.
• W4366768202 cites W2998586985 @default.
• W4366768202 cites W3004642442 @default.
• W4366768202 cites W3006786463 @default.
• W4366768202 cites W3007173362 @default.
• W4366768202 cites W3015100957 @default.
• W4366768202 cites W3016145305 @default.
• W4366768202 cites W3032684375 @default.
• W4366768202 cites W3043854668 @default.
• W4366768202 cites W3097089514 @default.
• W4366768202 cites W3109165223 @default.
• W4366768202 cites W3135354451 @default.
• W4366768202 cites W3159055070 @default.
• W4366768202 cites W3164014129 @default.
• W4366768202 cites W3170918328 @default.
• W4366768202 cites W3174557918 @default.
• W4366768202 cites W3194090444 @default.
• W4366768202 cites W4200074879 @default.
• W4366768202 cites W4210757594 @default.
• W4366768202 cites W4289172237 @default.
• W4366768202 doi "https://doi.org/10.1186/s12943-023-01773-3" @default.
• W4366768202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37087475" @default.
• W4366768202 hasPublicationYear "2023" @default.
• W4366768202 type Work @default.
• W4366768202 citedByCount "3" @default.
• W4366768202 countsByYear W43667682022023 @default.
• W4366768202 crossrefType "journal-article" @default.
• W4366768202 hasAuthorship W4366768202A5004370633 @default.
• W4366768202 hasAuthorship W4366768202A5006859983 @default.
• W4366768202 hasAuthorship W4366768202A5012934231 @default.
• W4366768202 hasAuthorship W4366768202A5024286539 @default.
• W4366768202 hasAuthorship W4366768202A5033350250 @default.
• W4366768202 hasAuthorship W4366768202A5037018453 @default.
• W4366768202 hasAuthorship W4366768202A5043888756 @default.
• W4366768202 hasAuthorship W4366768202A5044265859 @default.
• W4366768202 hasAuthorship W4366768202A5049453966 @default.
• W4366768202 hasAuthorship W4366768202A5071498928 @default.
• W4366768202 hasAuthorship W4366768202A5079233449 @default.
• W4366768202 hasAuthorship W4366768202A5089642545 @default.
• W4366768202 hasBestOaLocation W43667682021 @default.
• W4366768202 hasConcept C104317684 @default.
• W4366768202 hasConcept C121608353 @default.
• W4366768202 hasConcept C127561419 @default.
• W4366768202 hasConcept C134459356 @default.
• W4366768202 hasConcept C25602115 @default.
• W4366768202 hasConcept C41091548 @default.
• W4366768202 hasConcept C502942594 @default.
• W4366768202 hasConcept C526805850 @default.
• W4366768202 hasConcept C54355233 @default.
• W4366768202 hasConcept C55493867 @default.
• W4366768202 hasConcept C555283112 @default.
• W4366768202 hasConcept C86803240 @default.
• W4366768202 hasConcept C95444343 @default.
• W4366768202 hasConceptScore W4366768202C104317684 @default.
• W4366768202 hasConceptScore W4366768202C121608353 @default.
• W4366768202 hasConceptScore W4366768202C127561419 @default.
• W4366768202 hasConceptScore W4366768202C134459356 @default.
• W4366768202 hasConceptScore W4366768202C25602115 @default.
• W4366768202 hasConceptScore W4366768202C41091548 @default.
• W4366768202 hasConceptScore W4366768202C502942594 @default.

• next