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• W4366768758 abstract "<sec><strong>BACKGROUND</strong> Clinical outcomes of patients with non-valvular atrial fibrillation (AF) in Asian populations may be different from non-Asians. In this study, we aimed to determine the incidence of ischemic stroke/systemic embolism (SSE), major bleeding, and death, and the predictors for clinical outcomes in a contemporary Asian cohort of newly diagnosed AF patients. </sec><sec><strong>METHODS</strong> This is a prospective multicenter nationwide registry of patients with AF from 27 hospitals in Thailand. Baseline data and follow-up data were collected every 6 months until 3 years. Data collections included demographic, medical history, laboratory, and medication details. Clinical outcomes were SSE, major bleeding, and all-cause mortality. Incidence rates for each clinical outcome were calculated and presented as rate per 100 person-years. Univariate and multivariate analysis was performed to determine the independent predictors for clinical outcomes. </sec><sec><strong>RESULTS</strong> There was a total of 3405 patients: mean age was 67.8 ± 11.3 years, 1981 (58.2%) were male. During 30.8 ± 9.7 months follow-up, there was a total of 132 SSE (3.9%), 191 major bleeding (5.6%), and 357 all-cause deaths (10.5%). The incidence rates of SSE, major bleeding, and death were 1.56 (1.30-1.84), 2.26 (1.96-2.61), and 4.17 (3.33-4.25), per 100 person-years respectively. Independent predictors for clinical outcomes were age, type of AF, and the presence of comorbid conditions. </sec><sec><strong>CONCLUSION</strong> The incidence rate of SSE, major bleeding, and death remains high reflecting the unmet needs in AF management. </sec>" @default.
• W4366768758 created "2023-04-25" @default.
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• W4366768758 date "2023-03-01" @default.
• W4366768758 modified "2023-09-27" @default.
• W4366768758 title "Three-year outcomes of patients with non-valvular atrial fibrillation: the COOL-AF registry" @default.
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• W4366768758 doi "https://doi.org/10.26599/1671-5411.2023.03.008" @default.
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