FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366772323> ?p ?o ?g. }

• W4366772323 abstract "In vivo methods to estimate human liver mitochondrial activity are lacking and this project's goal was to use a non-invasive breath test to quantify complete mitochondrial fat oxidation and determine how test results changed when liver disease state was altered over time. Patients with suspected non-alcoholic fatty liver disease (NAFLD; 9 men, 16 women, 47 ± 10 years, 113 ± 23 kg) underwent a diagnostic liver biopsy and liver tissue was histologically scored by a pathologist using the NAFLD activity score (0-8). To assess liver oxidation activity, a labeled medium chain fatty acid was consumed orally (23.4 mg 13C4-octanoate) and breath samples collected over 135 min. Total CO2 production rates were measured using breath 13CO2 analysis by isotope ratio mass spectrometry. Fasting endogenous glucose production (EGP) was measured using an IV infusion of 13C6-glucose. At baseline, subjects oxidized 23.4 ± 3.9% (14.9%-31.5%) of the octanoate dose and octanoate oxidation (OctOx) was negatively correlated with fasting plasma glucose (r = -0.474, p = 0.017) and EGP (r = -0.441, p = 0.028). Twenty-two subjects returned for repeat tests 10.2 ± 1.0 months later, following lifestyle treatment or standardized care. OctOx (% dose/kg) was significantly greater across all subjects (p = 0.044), negatively related to reductions in EGP (r = -0.401, p = 0.064), and tended to correlate with reduced fasting glucose (r = -0.371, p = 0.090). Subjects exhibited reductions in steatosis (p = 0.007) which tended to correlate with increased OctOx (% of dose/kg, r = -0.411, p = 0.058). Based on our findings, the use of an 13C-octanoate breath test may be an indicator of hepatic steatosis and glucose metabolism, but these relationships require verification through larger studies in NAFLD populations." @default.
• W4366772323 created "2023-04-25" @default.
• W4366772323 creator A5007328363 @default.
• W4366772323 creator A5062744908 @default.
• W4366772323 creator A5068646728 @default.
• W4366772323 creator A5077611705 @default.
• W4366772323 creator A5079202585 @default.
• W4366772323 creator A5081380247 @default.
• W4366772323 creator A5087481772 @default.
• W4366772323 date "2023-04-21" @default.
• W4366772323 modified "2023-10-18" @default.
• W4366772323 title "Labeled breath tests in patients with NASH: Octanoate oxidation relates best to measures of glucose metabolism" @default.
• W4366772323 cites W1557705378 @default.
• W4366772323 cites W1930708124 @default.
• W4366772323 cites W1953743184 @default.
• W4366772323 cites W1966482757 @default.
• W4366772323 cites W1967553841 @default.
• W4366772323 cites W1968872717 @default.
• W4366772323 cites W1973866760 @default.
• W4366772323 cites W1982347002 @default.
• W4366772323 cites W1985236262 @default.
• W4366772323 cites W1988360070 @default.
• W4366772323 cites W1995642681 @default.
• W4366772323 cites W2002711503 @default.
• W4366772323 cites W2012774229 @default.
• W4366772323 cites W2012898950 @default.
• W4366772323 cites W2024986726 @default.
• W4366772323 cites W2028793842 @default.
• W4366772323 cites W2036344921 @default.
• W4366772323 cites W2041265416 @default.
• W4366772323 cites W2043864088 @default.
• W4366772323 cites W2045956199 @default.
• W4366772323 cites W2046366979 @default.
• W4366772323 cites W2071867050 @default.
• W4366772323 cites W2074203821 @default.
• W4366772323 cites W2078166385 @default.
• W4366772323 cites W2084382398 @default.
• W4366772323 cites W2086889982 @default.
• W4366772323 cites W2087526887 @default.
• W4366772323 cites W2088672916 @default.
• W4366772323 cites W2091106363 @default.
• W4366772323 cites W2091450162 @default.
• W4366772323 cites W2092412670 @default.
• W4366772323 cites W2109879785 @default.
• W4366772323 cites W2111995113 @default.
• W4366772323 cites W2113880648 @default.
• W4366772323 cites W2113913625 @default.
• W4366772323 cites W2117233341 @default.
• W4366772323 cites W2128469667 @default.
• W4366772323 cites W2130773379 @default.
• W4366772323 cites W2131375116 @default.
• W4366772323 cites W2132329816 @default.
• W4366772323 cites W2133985126 @default.
• W4366772323 cites W2134049755 @default.
• W4366772323 cites W2141165278 @default.
• W4366772323 cites W2142415239 @default.
• W4366772323 cites W2145407244 @default.
• W4366772323 cites W2160234571 @default.
• W4366772323 cites W2160283765 @default.
• W4366772323 cites W2162051951 @default.
• W4366772323 cites W2162819835 @default.
• W4366772323 cites W2166545507 @default.
• W4366772323 cites W2170282886 @default.
• W4366772323 cites W2175091172 @default.
• W4366772323 cites W2196957880 @default.
• W4366772323 cites W2253498406 @default.
• W4366772323 cites W2262387844 @default.
• W4366772323 cites W2291173445 @default.
• W4366772323 cites W2404525043 @default.
• W4366772323 cites W2410543948 @default.
• W4366772323 cites W2607031541 @default.
• W4366772323 cites W2615010360 @default.
• W4366772323 cites W2759997926 @default.
• W4366772323 cites W2770129291 @default.
• W4366772323 cites W2945024704 @default.
• W4366772323 cites W3017296042 @default.
• W4366772323 cites W3021032346 @default.
• W4366772323 cites W3128868402 @default.
• W4366772323 cites W3184661890 @default.
• W4366772323 cites W3190597188 @default.
• W4366772323 cites W40275277 @default.
• W4366772323 cites W4205486841 @default.
• W4366772323 cites W4220834227 @default.
• W4366772323 cites W4235609024 @default.
• W4366772323 cites W4284697415 @default.
• W4366772323 cites W90736706 @default.
• W4366772323 doi "https://doi.org/10.3389/fphys.2023.1172675" @default.
• W4366772323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37153214" @default.
• W4366772323 hasPublicationYear "2023" @default.
• W4366772323 type Work @default.
• W4366772323 citedByCount "0" @default.
• W4366772323 crossrefType "journal-article" @default.
• W4366772323 hasAuthorship W4366772323A5007328363 @default.
• W4366772323 hasAuthorship W4366772323A5062744908 @default.
• W4366772323 hasAuthorship W4366772323A5068646728 @default.
• W4366772323 hasAuthorship W4366772323A5077611705 @default.
• W4366772323 hasAuthorship W4366772323A5079202585 @default.
• W4366772323 hasAuthorship W4366772323A5081380247 @default.
• W4366772323 hasAuthorship W4366772323A5087481772 @default.
• W4366772323 hasBestOaLocation W43667723231 @default.

• next