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- W4366773362 abstract "The prognosis for glioblastoma has remained poor despite multimodal standard of care treatment, including temozolomide, radiation, and surgical resection. Further, the addition of immunotherapies, while promising in a number of other solid tumors, has overwhelmingly failed in the treatment of gliomas, in part due to the immunosuppressive microenvironment and poor drug penetrance to the brain. Local delivery of immunomodulatory therapies circumvents some of these challenges and has led to long-term remission in select patients. Many of these approaches utilize convection-enhanced delivery (CED) for immunological drug delivery, allowing high doses to be delivered directly to the brain parenchyma, avoiding systemic toxicity. Here, we review the literature encompassing immunotherapies delivered via CED-from preclinical model systems to clinical trials-and explore how their unique combination elicits an antitumor response by the immune system, decreases toxicity, and improves survival among select high-grade glioma patients." @default.
- W4366773362 created "2023-04-25" @default.
- W4366773362 creator A5046673359 @default.
- W4366773362 creator A5055848888 @default.
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- W4366773362 creator A5075850084 @default.
- W4366773362 date "2023-01-01" @default.
- W4366773362 modified "2023-10-05" @default.
- W4366773362 title "Convection-enhanced delivery of immunomodulatory therapy for high-grade glioma" @default.
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