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- W4366775360 abstract "PURPOSE: On September 8th, 2022, the FDA released a safety communication about various lymphomas and squamous cell carcinoma (SCC) arising within breast implant capsules. The purpose of this study is to perform a systematic review of cases world-wide, and describe our institutional experience, which is the largest series to date. METHODS: A systematic review of the literature was performed to identify breast implant-associated malignancies, specifically breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), B cell lymphoma (BIA-BCL) and BIA-SCC. Secondarily, chart review of cases presenting at our institution was performed for presentation, diagnosis, treatment regimens, and outcomes. RESULTS: We report 1,290 cases of BIA-ALCL worldwide, with 69 managed at our institution. All clinical histories when available involved a history of textured devices. The majority of cases were limited to the capsule, with distant spread uncommon. 30 cases of BIA-BCL worldwide have been reported, with eight at our institution. BCLs were heterogeneous, including diffuse large B cell lymphoma, follicular lymphoma, marginal zone lymphoma, Epstein-Barr virus fibrin-associated B-cell lymphoma, plasmablastic lymphoma, as well as several other variants. There have been 16 cases of BIA-SCC reported worldwide, and two institutional cases. Prognosis was more guarded than BIA-ALCL with extracapsular and distant spread significantly more common. CONCLUSION: National Comprehensive Cancer Network (NCCN) guidelines exist for BIA-ALCL management and we present updated recommendations on BIA-BCL and BIA-SCC. Increasing awareness of breast implant associated malignancies is needed to help clinicians diagnose these rare cancers." @default.
- W4366775360 created "2023-04-25" @default.
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- W4366775360 date "2023-04-01" @default.
- W4366775360 modified "2023-09-27" @default.
- W4366775360 title "9. Breast Implant Associated Chronic Inflammatory Malignancies" @default.
- W4366775360 doi "https://doi.org/10.1097/01.gox.0000934160.18286.ce" @default.
- W4366775360 hasPublicationYear "2023" @default.
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