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- W4366779056 endingPage "131465" @default.
- W4366779056 startingPage "131465" @default.
- W4366779056 abstract "In the era of plastic use, organisms are constantly exposed to polystyrene particles (PS-Ps). PS-Ps accumulated in living organisms exert negative effects on the body, although studies evaluating their effects on brain development are scarce. In this study, the effects of PS-Ps on nervous system development were investigated using cultured primary cortical neurons and mice exposed to PS-Ps at different stages of brain development. The gene expression associated with brain development was downregulated in embryonic brains following PS-Ps exposure, and Gabra2 expression decreased in the embryonic and adult mice exposed to PS-Ps. Additionally, offspring of PS-Ps-treated dams exhibited signs of anxiety- and depression-like behavior, and abnormal social behavior. We propose that PS-Ps accumulation in the brain disrupts brain development and behavior in mice. This study provides novel information regarding PS-Ps toxicity and its harmful effects on neural development and behavior in mammals." @default.
- W4366779056 created "2023-04-25" @default.
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- W4366779056 date "2023-07-01" @default.
- W4366779056 modified "2023-09-27" @default.
- W4366779056 title "Exposure to polystyrene particles causes anxiety-, depression-like behavior and abnormal social behavior in mice" @default.
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- W4366779056 doi "https://doi.org/10.1016/j.jhazmat.2023.131465" @default.
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