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• W4366779183 endingPage "106314" @default.
• W4366779183 startingPage "106314" @default.
• W4366779183 abstract "Vitamin D contributes to the development and maintenance of bone. Evidence suggests vitamin D status can also alter energy balance and gut health. In young animals, vitamin D deficiency (VDD) negatively affects bone mineral density (BMD) and bone microarchitecture, and these effects may also occur due to chronic ethanol intake. However, evidence is limited in mature models, and addressing this was a goal of the current study. Seven-month-old female C57BL/6 mice (n = 40) were weight-matched and randomized to one of four ad libitum diets: control, alcohol (Alc), vitamin D deficient (0 IU/d), or Alc+VDD for 8 weeks. A purified (AIN-93) diet was provided with water or alcohol (10 %) ad libitum. Body weight and food intake were recorded weekly, and feces were collected at 0, 4, and 8 weeks. At the age of 9 months, intestinal permeability was assessed by oral gavage of fluorescein isothiocyanate-dextran. Thereafter, bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry. The microarchitecture of the distal femur was assessed by micro-computed tomography and biomechanical properties were evaluated by cyclic reference point indentation. VDD did not affect BMD or most bone microarchitecture parameters, however, the polar moment of inertia (p < 0.05) was higher in the VDD groups compared to vitamin D sufficient groups. VDD mice also had lower whole bone water content (p < 0.05) and a greater average unloading slope (p < 0.01), and energy dissipated (p < 0.01), indicating the femur displayed a brittle phenotype. In addition, VDD caused a greater increase in energy intake (p < 0.05), weight gain (p < 0.05), and a trend for higher intestinal permeability (p = 0.08). The gut microbiota of the VDD group had a reduction in alpha diversity (p < 0.05) and a lower abundance of ASVs from Rikenellaceae, Clostridia_UCG-014, Oscillospiraceae, and Lachnospiraceae (p < 0.01). There was little to no effect of alcohol supplementation on outcomes. Overall, these findings suggest that vitamin D deficiency causes excess weight gain and reduces the biomechanical strength of the femur as indicated by the higher average unloading slope and energy dissipated without an effect on BMD in a mature murine model." @default.
• W4366779183 created "2023-04-25" @default.
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• W4366779183 date "2023-07-01" @default.
• W4366779183 modified "2023-10-18" @default.
• W4366779183 title "A vitamin D deficient diet increases weight gain and compromises bone biomechanical properties without a reduction in BMD in adult female mice" @default.
• W4366779183 cites W1010833643 @default.
• W4366779183 cites W1422813766 @default.
• W4366779183 cites W1550407775 @default.
• W4366779183 cites W1571896605 @default.
• W4366779183 cites W1900820315 @default.
• W4366779183 cites W1967967197 @default.
• W4366779183 cites W1979976380 @default.
• W4366779183 cites W1981958853 @default.
• W4366779183 cites W1985792013 @default.
• W4366779183 cites W1986689077 @default.
• W4366779183 cites W1988286489 @default.
• W4366779183 cites W1988443593 @default.
• W4366779183 cites W1989944462 @default.
• W4366779183 cites W1990716431 @default.
• W4366779183 cites W2000329128 @default.
• W4366779183 cites W2009662509 @default.
• W4366779183 cites W2027330415 @default.
• W4366779183 cites W2027969892 @default.
• W4366779183 cites W2031524973 @default.
• W4366779183 cites W2032288122 @default.
• W4366779183 cites W2037565685 @default.
• W4366779183 cites W2048629034 @default.
• W4366779183 cites W2051567523 @default.
• W4366779183 cites W2051624074 @default.
• W4366779183 cites W2051775115 @default.
• W4366779183 cites W2066749771 @default.
• W4366779183 cites W2072970694 @default.
• W4366779183 cites W2075194927 @default.
• W4366779183 cites W2077604951 @default.
• W4366779183 cites W2081485841 @default.
• W4366779183 cites W2087575862 @default.
• W4366779183 cites W2094856707 @default.
• W4366779183 cites W2100047947 @default.
• W4366779183 cites W2110630908 @default.
• W4366779183 cites W2110874171 @default.
• W4366779183 cites W2111567870 @default.
• W4366779183 cites W2111604217 @default.
• W4366779183 cites W2126891625 @default.
• W4366779183 cites W2131264460 @default.
• W4366779183 cites W2133808995 @default.
• W4366779183 cites W2136803357 @default.
• W4366779183 cites W2140804784 @default.
• W4366779183 cites W2145664556 @default.
• W4366779183 cites W2146578355 @default.
• W4366779183 cites W2150924729 @default.
• W4366779183 cites W2153059487 @default.
• W4366779183 cites W2154733522 @default.
• W4366779183 cites W2155193764 @default.
• W4366779183 cites W2159877191 @default.
• W4366779183 cites W2166655850 @default.
• W4366779183 cites W2167062509 @default.
• W4366779183 cites W2336384564 @default.
• W4366779183 cites W2347173394 @default.
• W4366779183 cites W2401404581 @default.
• W4366779183 cites W2404959973 @default.
• W4366779183 cites W2420491733 @default.
• W4366779183 cites W2518325590 @default.
• W4366779183 cites W2554916856 @default.
• W4366779183 cites W2563720483 @default.
• W4366779183 cites W2594496417 @default.
• W4366779183 cites W2678211758 @default.
• W4366779183 cites W2800874976 @default.
• W4366779183 cites W2803790829 @default.
• W4366779183 cites W2913249953 @default.
• W4366779183 cites W2944325924 @default.
• W4366779183 cites W2944533085 @default.
• W4366779183 cites W2956603861 @default.
• W4366779183 cites W3011269268 @default.
• W4366779183 cites W3016828764 @default.
• W4366779183 cites W3044163369 @default.
• W4366779183 cites W3084302643 @default.
• W4366779183 cites W3094034464 @default.
• W4366779183 cites W3110715890 @default.
• W4366779183 cites W3135248064 @default.
• W4366779183 cites W3200783951 @default.
• W4366779183 cites W3203514284 @default.
• W4366779183 cites W3211779138 @default.
• W4366779183 cites W4224258098 @default.
• W4366779183 doi "https://doi.org/10.1016/j.jsbmb.2023.106314" @default.
• W4366779183 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37088440" @default.
• W4366779183 hasPublicationYear "2023" @default.

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