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- W4366813764 abstract "Abstract All addictive disorders consist of two key, interacting features: persistent subjective craving and maladaptive choice behaviors. However, the computations underlying the bidirectional relationship between craving and decision-making remain unknown. Here, we tested a hypothesis that momentary craving and value-based decision-making dynamically influence each other across addictive domains. We sampled momentary craving as three groups of participants (alcohol drinkers, cannabis users, and binge eaters; total n =202) performed a probabilistic learning task in which they received either monetary or group-specific addictive cue rewards. Using computational modeling, we found that momentary craving dynamically biased towards faster learning during addictive but not monetary decision-making across all groups. Conversely, we also found that prediction errors modulated perceived craving. Computational parameters underlying these latent mechanisms were reliably predictive of clinical severity. These findings provide a computational mechanism for the interaction between craving and choice behavior that is generalizable across addictive domains." @default.
- W4366813764 created "2023-04-25" @default.
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- W4366813764 date "2023-04-24" @default.
- W4366813764 modified "2023-09-23" @default.
- W4366813764 title "A generalizable computational mechanism underlying the interaction between momentary craving and decision-making" @default.
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- W4366813764 doi "https://doi.org/10.1101/2023.04.24.538109" @default.
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