FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366813820> ?p ?o ?g. }

• W4366813820 abstract "Interictal spikes (IIS) occur in 3 mouse lines with Alzheimer's disease featuresIIS in all 3 mouse lines were most frequent during rapid eye movement (REM) sleepThe dentate gyrus showed larger IIS and earlier current sources vs. CA1 or cortexChemogenetic silencing of medial septum (MS) cholinergic neurons reduced IIS during REMMS silencing did not change REM latency, duration, number of bouts or theta power.Interictal spikes (IIS) are a common type of abnormal electrical activity in Alzheimer's disease (AD) and preclinical models. The brain regions where IIS are largest are not known but are important because such data would suggest sites that contribute to IIS generation. Because hippocampus and cortex exhibit altered excitability in AD models, we asked which areas dominate the activity during IIS along the cortical-CA1-dentate gyrus (DG) dorso-ventral axis. Because medial septal (MS) cholinergic neurons are overactive when IIS typically occur, we also tested the novel hypothesis that silencing the MS cholinergic neurons selectively would reduce IIS.We used mice that simulate aspects of AD: Tg2576 mice, presenilin 2 (PS2) knockout mice and Ts65Dn mice. To selectively silence MS cholinergic neurons, Tg2576 mice were bred with choline-acetyltransferase (ChAT)-Cre mice and offspring were injected in the MS with AAV encoding inhibitory designer receptors exclusively activated by designer drugs (DREADDs). We recorded local field potentials along the cortical-CA1-DG axis using silicon probes during wakefulness, slow-wave sleep (SWS) and rapid eye movement (REM) sleep.We detected IIS in all transgenic or knockout mice but not age-matched controls. IIS were detectable throughout the cortical-CA1-DG axis and occurred primarily during REM sleep. In all 3 mouse lines, IIS amplitudes were significantly greater in the DG granule cell layer vs. CA1 pyramidal layer or overlying cortex. Current source density analysis showed robust and early current sources in the DG, and additional sources in CA1 and the cortex also. Selective chemogenetic silencing of MS cholinergic neurons significantly reduced IIS rate during REM sleep without affecting the overall duration, number of REM bouts, latency to REM sleep, or theta power during REM. Notably, two control interventions showed no effects.Consistent maximal amplitude and strong current sources of IIS in the DG suggest that the DG is remarkably active during IIS. In addition, selectively reducing MS cholinergic tone, at times when MS is hyperactive, could be a new strategy to reduce IIS in AD." @default.
• W4366813820 created "2023-04-25" @default.
• W4366813820 creator A5013260521 @default.
• W4366813820 creator A5087367713 @default.
• W4366813820 date "2023-04-24" @default.
• W4366813820 modified "2023-10-12" @default.
• W4366813820 title "Interictal Spikes in Alzheimer’s Disease: Preclinical Evidence for Dominance of the Dentate Gyrus and Cholinergic Control by Medial Septum" @default.
• W4366813820 cites W1513242172 @default.
• W4366813820 cites W1558527220 @default.
• W4366813820 cites W1570043013 @default.
• W4366813820 cites W1853425391 @default.
• W4366813820 cites W1894747531 @default.
• W4366813820 cites W1900601199 @default.
• W4366813820 cites W1929267935 @default.
• W4366813820 cites W1963617392 @default.
• W4366813820 cites W1968531410 @default.
• W4366813820 cites W1970242204 @default.
• W4366813820 cites W1970910654 @default.
• W4366813820 cites W1972153963 @default.
• W4366813820 cites W1973050784 @default.
• W4366813820 cites W1973629574 @default.
• W4366813820 cites W1976513474 @default.
• W4366813820 cites W1980703499 @default.
• W4366813820 cites W1980732458 @default.
• W4366813820 cites W1985471830 @default.
• W4366813820 cites W1992388076 @default.
• W4366813820 cites W1992431848 @default.
• W4366813820 cites W1992606600 @default.
• W4366813820 cites W1994067502 @default.
• W4366813820 cites W1995170630 @default.
• W4366813820 cites W2001210466 @default.
• W4366813820 cites W2003320905 @default.
• W4366813820 cites W2004852048 @default.
• W4366813820 cites W2005260297 @default.
• W4366813820 cites W2005695597 @default.
• W4366813820 cites W2010891279 @default.
• W4366813820 cites W2011303819 @default.
• W4366813820 cites W2011519644 @default.
• W4366813820 cites W2013177991 @default.
• W4366813820 cites W2018930679 @default.
• W4366813820 cites W2020690996 @default.
• W4366813820 cites W2020822926 @default.
• W4366813820 cites W2026576926 @default.
• W4366813820 cites W2026802237 @default.
• W4366813820 cites W2030669013 @default.
• W4366813820 cites W2033791936 @default.
• W4366813820 cites W2035169503 @default.
• W4366813820 cites W2036322060 @default.
• W4366813820 cites W2041789591 @default.
• W4366813820 cites W2041800086 @default.
• W4366813820 cites W2042938678 @default.
• W4366813820 cites W2048685634 @default.
• W4366813820 cites W2050215995 @default.
• W4366813820 cites W2051883633 @default.
• W4366813820 cites W2054040386 @default.
• W4366813820 cites W2055776806 @default.
• W4366813820 cites W2056114929 @default.
• W4366813820 cites W2065087912 @default.
• W4366813820 cites W2073374252 @default.
• W4366813820 cites W2076358196 @default.
• W4366813820 cites W2078177672 @default.
• W4366813820 cites W2083709268 @default.
• W4366813820 cites W2086162146 @default.
• W4366813820 cites W2086991865 @default.
• W4366813820 cites W2097391583 @default.
• W4366813820 cites W2098676436 @default.
• W4366813820 cites W2099268443 @default.
• W4366813820 cites W2120543763 @default.
• W4366813820 cites W2132718296 @default.
• W4366813820 cites W2136901555 @default.
• W4366813820 cites W2139147515 @default.
• W4366813820 cites W2142746788 @default.
• W4366813820 cites W2149917862 @default.
• W4366813820 cites W2156152247 @default.
• W4366813820 cites W2156899873 @default.
• W4366813820 cites W2156910937 @default.
• W4366813820 cites W2161924901 @default.
• W4366813820 cites W2163301650 @default.
• W4366813820 cites W2168312889 @default.
• W4366813820 cites W2170446709 @default.
• W4366813820 cites W2171623992 @default.
• W4366813820 cites W2275148408 @default.
• W4366813820 cites W2288238997 @default.
• W4366813820 cites W2296860665 @default.
• W4366813820 cites W2341354469 @default.
• W4366813820 cites W2399670039 @default.
• W4366813820 cites W2405001780 @default.
• W4366813820 cites W2413686208 @default.
• W4366813820 cites W2414380634 @default.
• W4366813820 cites W2467615517 @default.
• W4366813820 cites W2476248361 @default.
• W4366813820 cites W2514879313 @default.
• W4366813820 cites W2527558243 @default.
• W4366813820 cites W2529680063 @default.
• W4366813820 cites W2553673437 @default.
• W4366813820 cites W2560825041 @default.
• W4366813820 cites W2580396096 @default.
• W4366813820 cites W2581512771 @default.
• W4366813820 cites W2581980900 @default.
• W4366813820 cites W2599512437 @default.

• next