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- W4366815841 abstract "Despite advances in biomaterials engineering, a large gap remains between the weak mechanical properties that can be achieved with natural materials and the strength of synthetic materials. Here, a method is presented for reinforcing an engineered cardiac tissue fabricated from differentiated induced pluripotent stem cells (iPSCs) and an extracellular matrix (ECM)-based hydrogel in a manner that is fully biocompatible. The reinforcement occurs as a post-fabrication step, which allows for the use of 3D-printing technology to generate thick, fully cellularized, and vascularized cardiac tissues. After tissue assembly and during the maturation process in a soft hydrogel, a small, tissue-penetrating reinforcer is deployed, leading to a significant increase in the tissue's mechanical properties. The tissue's robustness is demonstrated by injecting the tissue in a simulated minimally invasive procedure and showing that the tissue is functional and undamaged at the nano-, micro-, and macroscales." @default.
- W4366815841 created "2023-04-25" @default.
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- W4366815841 date "2023-06-11" @default.
- W4366815841 modified "2023-10-05" @default.
- W4366815841 title "Post‐Maturation Reinforcement of 3D‐Printed Vascularized Cardiac Tissues" @default.
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- W4366815841 doi "https://doi.org/10.1002/adma.202302229" @default.
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