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- W4366819674 abstract "Malignant gliomas are known to be one of the most difficult diseases to diagnose and treat because of the infiltrative growth pattern, rapid progression, and poor prognosis. Many antitumor drugs are not ideal for the treatment of gliomas due to the blood-brain barrier. Temozolomide (TMZ) is a DNA alkylating agent that can cross the blood-brain barrier. As the only first-line chemotherapeutic drug for malignant gliomas at present, TMZ is widely utilized to provide a survival benefit; however, some patients are inherently insensitive to TMZ. In addition, patients could develop acquired resistance during TMZ treatment, which limits antitumor efficacy. To clarify the mechanism underlying TMZ resistance, numerous studies have provided multilevel solutions, such as improving the effective concentration of TMZ in tumors and developing novel small molecule drugs. This review discusses the in-depth mechanisms underlying TMZ drug resistance, thus aiming to provide possibilities for the establishment of personalized therapeutic strategies against malignant gliomas and the accelerated development and transformation of new targeted drugs." @default.
- W4366819674 created "2023-04-25" @default.
- W4366819674 creator A5011724071 @default.
- W4366819674 creator A5014417472 @default.
- W4366819674 creator A5039882839 @default.
- W4366819674 creator A5045507453 @default.
- W4366819674 creator A5059343454 @default.
- W4366819674 date "2023-04-25" @default.
- W4366819674 modified "2023-09-25" @default.
- W4366819674 title "Expert opinion on translational research for advanced glioblastoma treatment" @default.
- W4366819674 cites W1777661785 @default.
- W4366819674 cites W1861898234 @default.
- W4366819674 cites W1864544636 @default.
- W4366819674 cites W1902577542 @default.
- W4366819674 cites W1943407880 @default.
- W4366819674 cites W1953042185 @default.
- W4366819674 cites W1978853965 @default.
- W4366819674 cites W1987610133 @default.
- W4366819674 cites W2007988355 @default.
- W4366819674 cites W2010677999 @default.
- W4366819674 cites W2018101112 @default.
- W4366819674 cites W2030017878 @default.
- W4366819674 cites W2036044314 @default.
- W4366819674 cites W2039075677 @default.
- W4366819674 cites W2045510579 @default.
- W4366819674 cites W2071123870 @default.
- W4366819674 cites W2073406358 @default.
- W4366819674 cites W2084170466 @default.
- W4366819674 cites W2084251083 @default.
- W4366819674 cites W2089482729 @default.
- W4366819674 cites W2097478662 @default.
- W4366819674 cites W2098142549 @default.
- W4366819674 cites W2105100844 @default.
- W4366819674 cites W2109816625 @default.
- W4366819674 cites W2110275053 @default.
- W4366819674 cites W2115736737 @default.
- W4366819674 cites W2138800281 @default.
- W4366819674 cites W2147129352 @default.
- W4366819674 cites W2158681922 @default.
- W4366819674 cites W2161289668 @default.
- W4366819674 cites W2165169849 @default.
- W4366819674 cites W2165871546 @default.
- W4366819674 cites W2167210027 @default.
- W4366819674 cites W2328946792 @default.
- W4366819674 cites W2392045628 @default.
- W4366819674 cites W2474528906 @default.
- W4366819674 cites W2475107749 @default.
- W4366819674 cites W2591531756 @default.
- W4366819674 cites W2599750069 @default.
- W4366819674 cites W2615491662 @default.
- W4366819674 cites W2727830163 @default.
- W4366819674 cites W2738678436 @default.
- W4366819674 cites W2778033786 @default.
- W4366819674 cites W2785262117 @default.
- W4366819674 cites W2791657935 @default.
- W4366819674 cites W2796552195 @default.
- W4366819674 cites W2797866384 @default.
- W4366819674 cites W2885253839 @default.
- W4366819674 cites W2896599301 @default.
- W4366819674 cites W2897407935 @default.
- W4366819674 cites W2910026377 @default.
- W4366819674 cites W2912368167 @default.
- W4366819674 cites W2917960773 @default.
- W4366819674 cites W2938828567 @default.
- W4366819674 cites W2942910851 @default.
- W4366819674 cites W2961217357 @default.
- W4366819674 cites W2970054604 @default.
- W4366819674 cites W3002439510 @default.
- W4366819674 cites W3005155748 @default.
- W4366819674 cites W3011606503 @default.
- W4366819674 cites W3012959001 @default.
- W4366819674 cites W3018583760 @default.
- W4366819674 cites W3023037803 @default.
- W4366819674 cites W3033277066 @default.
- W4366819674 cites W3033565962 @default.
- W4366819674 cites W3091031035 @default.
- W4366819674 cites W3091889888 @default.
- W4366819674 cites W3097646670 @default.
- W4366819674 cites W3119609126 @default.
- W4366819674 cites W3128964921 @default.
- W4366819674 cites W3158497484 @default.
- W4366819674 cites W3174246647 @default.
- W4366819674 cites W3180923567 @default.
- W4366819674 cites W3194848908 @default.
- W4366819674 cites W3197265554 @default.
- W4366819674 cites W3199105753 @default.
- W4366819674 cites W3201767295 @default.
- W4366819674 cites W4213305389 @default.
- W4366819674 cites W4221134810 @default.
- W4366819674 cites W4225785203 @default.
- W4366819674 cites W4226214867 @default.
- W4366819674 cites W4285228459 @default.
- W4366819674 cites W4288424910 @default.
- W4366819674 cites W4298326926 @default.
- W4366819674 cites W4301595791 @default.
- W4366819674 cites W4307092667 @default.
- W4366819674 cites W4308338035 @default.
- W4366819674 cites W571060166 @default.