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• W4366821620 endingPage "2269" @default.
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• W4366821620 abstract "Fluorescence molecular tomography (FMT) using fluorescence of the second near-infrared window (NIR-II) has been proved to outperform conventional FMT using fluorescence of the first near-infrared window (NIR-I). However, it was still a challenge to achieve a satisfactory reconstructed light source using NIR-II FMT as the NIR-IIa (1300-1400 nm) fluorescence in the NIR-II spectrum used in the previous NIR-II FMT study was still suffering from prominent absorption and scattering of tissue.A novel NIR-IIb (1500-1700 nm) FMT method was proposed and applied in the reconstruction of glioblastomas in animal models. Optical parameters that describe the effect of different tissue on the NIR-IIb photons were calculated to construct a light propagation model of NIR-IIb light to form the forward model. Besides, a novel adaptive projection matching pursuit (APMP) method was further adopted to accurately solve the inverse problem. Location error and Dice coefficient were used to evaluate the accuracy of reconstruction. Simulation experiments using single-source and dual-source and in vivo experiments were conducted to evaluate the reconstructed light source.Both simulation and in vivo experiments demonstrated that NIR-IIb FMT achieved reduced location error and improved shape similarity compared with NIR-IIa. NIR-IIb FMT of orthotopic mouse models further achieved a location error of 0.65 mm and a Dice coefficient of 0.56, which both outperformed NIR-IIa.The results demonstrated that NIR-IIb has better reconstruction performance for positioning accuracy and shape recovery.The inspiring results in this study demonstrate the effectiveness and advantages of NIR-IIb FMT in precise tumor positioning." @default.
• W4366821620 created "2023-04-25" @default.
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• W4366821620 date "2023-08-01" @default.
• W4366821620 modified "2023-10-15" @default.
• W4366821620 title "NIR-IIb Fluorescence Molecular Tomography of Glioblastomas Based on Heterogeneous Mouse Models and Adaptive Projection Match Pursuit Method" @default.
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• W4366821620 doi "https://doi.org/10.1109/tbme.2023.3239735" @default.
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