FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366822489> ?p ?o ?g. }

• W4366822489 abstract "Camptotheca acuminata Decne., the main source of camptothecin (CPT), has received increasing attention for its remarkable antitumor activity. Many CPT derivatives are clinically used as effective anticancer agents worldwide. However, their biosynthesis mechanism remains unclear, and uncovering this pathway would greatly facilitate development of alternative CPT production methods to replace current inefficient plant-derived ones. The expression of >30,000 genes was accurately quantified using unique molecular identifier RNA sequencing in 10 C. acuminata tissues, and 7854 proteins from five tissues were quantified with label-free quantitative proteomics. Fifteen full-length transcriptomes were sequenced with long-read Oxford Nanopore Technologies, and 5692 alternative splicing events were discovered among 4746 genes. Integrated transcriptome and proteome analysis provided novel insights into CPT biosynthesis and its hierarchical regulation. Five cytochrome P450s and three O-methyltransferases were considered as candidates involved in the biosynthesis of CPT and its derivatives, while 15 transcription factors potentially regulating CPT biosynthesis were screened. These findings provide important clues for elucidating the biosynthetic mechanisms of CPT and its derivatives and substantially contribute to the future production of these anticancer agents with synthetic biology. The generated large-scale multiomics data also provide valuable resources for investigating the functional genomics of the most important CPT-producing plant species-C. acuminata." @default.
• W4366822489 created "2023-04-25" @default.
• W4366822489 creator A5000383893 @default.
• W4366822489 creator A5004387966 @default.
• W4366822489 creator A5012801869 @default.
• W4366822489 creator A5020211480 @default.
• W4366822489 creator A5028124379 @default.
• W4366822489 creator A5060002817 @default.
• W4366822489 creator A5080855245 @default.
• W4366822489 creator A5086831639 @default.
• W4366822489 date "2023-05-01" @default.
• W4366822489 modified "2023-10-03" @default.
• W4366822489 title "Integrated transcriptome and proteome analysis provides new insights into camptothecin biosynthesis and regulation in <i>Camptotheca acuminata</i>" @default.
• W4366822489 cites W1520292993 @default.
• W4366822489 cites W1553701813 @default.
• W4366822489 cites W1562467541 @default.
• W4366822489 cites W1566005643 @default.
• W4366822489 cites W1791904664 @default.
• W4366822489 cites W1953554494 @default.
• W4366822489 cites W1964552518 @default.
• W4366822489 cites W1964803183 @default.
• W4366822489 cites W1966327575 @default.
• W4366822489 cites W1972222329 @default.
• W4366822489 cites W1988418086 @default.
• W4366822489 cites W2008922570 @default.
• W4366822489 cites W2040696578 @default.
• W4366822489 cites W2067279194 @default.
• W4366822489 cites W2079584495 @default.
• W4366822489 cites W2098277530 @default.
• W4366822489 cites W2138207763 @default.
• W4366822489 cites W2144660871 @default.
• W4366822489 cites W2152207030 @default.
• W4366822489 cites W2154586887 @default.
• W4366822489 cites W2159675211 @default.
• W4366822489 cites W2163516449 @default.
• W4366822489 cites W2169456326 @default.
• W4366822489 cites W2315065714 @default.
• W4366822489 cites W2470184937 @default.
• W4366822489 cites W2482462189 @default.
• W4366822489 cites W2544360569 @default.
• W4366822489 cites W2560535804 @default.
• W4366822489 cites W2735714195 @default.
• W4366822489 cites W2787742192 @default.
• W4366822489 cites W2797352891 @default.
• W4366822489 cites W2801180093 @default.
• W4366822489 cites W2801317575 @default.
• W4366822489 cites W2807548455 @default.
• W4366822489 cites W2900375424 @default.
• W4366822489 cites W2972856285 @default.
• W4366822489 cites W3010770034 @default.
• W4366822489 cites W3013769114 @default.
• W4366822489 cites W3042475334 @default.
• W4366822489 cites W3043073412 @default.
• W4366822489 cites W3121214078 @default.
• W4366822489 cites W3138678420 @default.
• W4366822489 cites W3167940477 @default.
• W4366822489 cites W3196796325 @default.
• W4366822489 cites W4200042234 @default.
• W4366822489 cites W4205402058 @default.
• W4366822489 cites W4206484110 @default.
• W4366822489 cites W4210465820 @default.
• W4366822489 cites W4220758634 @default.
• W4366822489 cites W4224299369 @default.
• W4366822489 cites W4292180748 @default.
• W4366822489 doi "https://doi.org/10.1111/ppl.13916" @default.
• W4366822489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37093159" @default.
• W4366822489 hasPublicationYear "2023" @default.
• W4366822489 type Work @default.
• W4366822489 citedByCount "0" @default.
• W4366822489 crossrefType "journal-article" @default.
• W4366822489 hasAuthorship W4366822489A5000383893 @default.
• W4366822489 hasAuthorship W4366822489A5004387966 @default.
• W4366822489 hasAuthorship W4366822489A5012801869 @default.
• W4366822489 hasAuthorship W4366822489A5020211480 @default.
• W4366822489 hasAuthorship W4366822489A5028124379 @default.
• W4366822489 hasAuthorship W4366822489A5060002817 @default.
• W4366822489 hasAuthorship W4366822489A5080855245 @default.
• W4366822489 hasAuthorship W4366822489A5086831639 @default.
• W4366822489 hasConcept C104317684 @default.
• W4366822489 hasConcept C104397665 @default.
• W4366822489 hasConcept C141231307 @default.
• W4366822489 hasConcept C150194340 @default.
• W4366822489 hasConcept C161078062 @default.
• W4366822489 hasConcept C162317418 @default.
• W4366822489 hasConcept C189206191 @default.
• W4366822489 hasConcept C2779682216 @default.
• W4366822489 hasConcept C46111723 @default.
• W4366822489 hasConcept C54355233 @default.
• W4366822489 hasConcept C553450214 @default.
• W4366822489 hasConcept C55493867 @default.
• W4366822489 hasConcept C70721500 @default.
• W4366822489 hasConcept C86803240 @default.
• W4366822489 hasConceptScore W4366822489C104317684 @default.
• W4366822489 hasConceptScore W4366822489C104397665 @default.
• W4366822489 hasConceptScore W4366822489C141231307 @default.
• W4366822489 hasConceptScore W4366822489C150194340 @default.
• W4366822489 hasConceptScore W4366822489C161078062 @default.
• W4366822489 hasConceptScore W4366822489C162317418 @default.
• W4366822489 hasConceptScore W4366822489C189206191 @default.
• W4366822489 hasConceptScore W4366822489C2779682216 @default.

• next