Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366825877> ?p ?o ?g. }
- W4366825877 endingPage "310" @default.
- W4366825877 startingPage "298" @default.
- W4366825877 abstract "The present study aimed to develop and investigate besifloxacin (BSF) in situ gel nanoemulsions (NEs) consisting of two hydrophilic polymers, that is, poloxamer 407 (P407) and poloxamer 188 (P188), for ocular delivery. BSF loaded in situ gel-NEs containing triacetin (oil), Cremophor ® RH 40 (surfactant), Transcutol ® P (co-surfactant), poloxamer 407 and poloxamer 188 (gelling agents) were prepared by spontaneous emulsification method. The optimum in situ gel nanoemulsion was selected based on gelation temperature. The selected formulation was evaluated for physicochemical characteristics, including droplet size, refractive index, pH, transparency, and viscosity. Further investigations such as in vitro drug release, ex vivo corneal permeation, HET-CAM, pre-corneal residence time antibacterial efficacy studies were conducted too. Developed BSF in situ gel nanoemulsion showed acceptable physicochemical properties with a nano-metric droplet size of 19 nm and PDI of 0.21. Moreover, In vitro release studies revealed that the in situ gel formulation could sustain drug release as only 40% of the BSF was released within 1 h. Permeability coefficient (Papp) of BSF through the excised bovine cornea was found 6.01 × 10 −6 cm/s during 6 h. In addition, the HET-CAM evaluation confirmed the non-irritancy of the optimum BSF in situ gel NEs. The pre-corneal residence time evaluation indicated prolonged retention of in situ gel-NEs on the eye surface. Finally, antibacterial susceptibility investigations illustrated remarkable efficacy against Pseudomonas aeruginosa and Staphylococcus aureus. The current findings demonstrated that this proposed BSF-loaded in situ gel-NEs could be considered as a potential novel drug delivery formulation against ophthalmic bacterial infections." @default.
- W4366825877 created "2023-04-25" @default.
- W4366825877 creator A5047351364 @default.
- W4366825877 creator A5066900047 @default.
- W4366825877 creator A5073678732 @default.
- W4366825877 date "2023-04-24" @default.
- W4366825877 modified "2023-09-25" @default.
- W4366825877 title "Fabrication of poloxamer based besifloxacin thermosensitive in situ gelling nanoemulsions for ophthalmic delivery" @default.
- W4366825877 cites W1968049805 @default.
- W4366825877 cites W1975298799 @default.
- W4366825877 cites W1983964958 @default.
- W4366825877 cites W1994442938 @default.
- W4366825877 cites W2026537351 @default.
- W4366825877 cites W2035861952 @default.
- W4366825877 cites W2068664895 @default.
- W4366825877 cites W2074417814 @default.
- W4366825877 cites W2164930226 @default.
- W4366825877 cites W2308973869 @default.
- W4366825877 cites W2469031345 @default.
- W4366825877 cites W2525922077 @default.
- W4366825877 cites W2565842908 @default.
- W4366825877 cites W2582280693 @default.
- W4366825877 cites W2605966271 @default.
- W4366825877 cites W2768183619 @default.
- W4366825877 cites W2777708226 @default.
- W4366825877 cites W2787711470 @default.
- W4366825877 cites W2790285176 @default.
- W4366825877 cites W2803725601 @default.
- W4366825877 cites W2888128523 @default.
- W4366825877 cites W2912138104 @default.
- W4366825877 cites W2914208290 @default.
- W4366825877 cites W2948033513 @default.
- W4366825877 cites W2951609113 @default.
- W4366825877 cites W2978513447 @default.
- W4366825877 cites W2986865289 @default.
- W4366825877 cites W2997405596 @default.
- W4366825877 cites W3004456848 @default.
- W4366825877 cites W3035842274 @default.
- W4366825877 cites W3039030773 @default.
- W4366825877 cites W3084295998 @default.
- W4366825877 cites W3092814851 @default.
- W4366825877 cites W3096406557 @default.
- W4366825877 cites W3127463256 @default.
- W4366825877 cites W3130349410 @default.
- W4366825877 cites W3133904216 @default.
- W4366825877 cites W3136505420 @default.
- W4366825877 cites W3150969889 @default.
- W4366825877 cites W3158232034 @default.
- W4366825877 cites W3161734289 @default.
- W4366825877 cites W3162060777 @default.
- W4366825877 cites W3162373751 @default.
- W4366825877 cites W3169833573 @default.
- W4366825877 cites W3170918866 @default.
- W4366825877 cites W3174567909 @default.
- W4366825877 cites W3200660792 @default.
- W4366825877 cites W4200523340 @default.
- W4366825877 cites W4254779814 @default.
- W4366825877 doi "https://doi.org/10.1177/08839115231167587" @default.
- W4366825877 hasPublicationYear "2023" @default.
- W4366825877 type Work @default.
- W4366825877 citedByCount "0" @default.
- W4366825877 crossrefType "journal-article" @default.
- W4366825877 hasAuthorship W4366825877A5047351364 @default.
- W4366825877 hasAuthorship W4366825877A5066900047 @default.
- W4366825877 hasAuthorship W4366825877A5073678732 @default.
- W4366825877 hasConcept C101335993 @default.
- W4366825877 hasConcept C15920480 @default.
- W4366825877 hasConcept C171250308 @default.
- W4366825877 hasConcept C178790620 @default.
- W4366825877 hasConcept C185592680 @default.
- W4366825877 hasConcept C192562407 @default.
- W4366825877 hasConcept C2777822432 @default.
- W4366825877 hasConcept C2779820397 @default.
- W4366825877 hasConcept C2780306666 @default.
- W4366825877 hasConcept C41625074 @default.
- W4366825877 hasConcept C43617362 @default.
- W4366825877 hasConcept C50670333 @default.
- W4366825877 hasConcept C521977710 @default.
- W4366825877 hasConcept C55493867 @default.
- W4366825877 hasConcept C58226133 @default.
- W4366825877 hasConceptScore W4366825877C101335993 @default.
- W4366825877 hasConceptScore W4366825877C15920480 @default.
- W4366825877 hasConceptScore W4366825877C171250308 @default.
- W4366825877 hasConceptScore W4366825877C178790620 @default.
- W4366825877 hasConceptScore W4366825877C185592680 @default.
- W4366825877 hasConceptScore W4366825877C192562407 @default.
- W4366825877 hasConceptScore W4366825877C2777822432 @default.
- W4366825877 hasConceptScore W4366825877C2779820397 @default.
- W4366825877 hasConceptScore W4366825877C2780306666 @default.
- W4366825877 hasConceptScore W4366825877C41625074 @default.
- W4366825877 hasConceptScore W4366825877C43617362 @default.
- W4366825877 hasConceptScore W4366825877C50670333 @default.
- W4366825877 hasConceptScore W4366825877C521977710 @default.
- W4366825877 hasConceptScore W4366825877C55493867 @default.
- W4366825877 hasConceptScore W4366825877C58226133 @default.
- W4366825877 hasFunder F4320322813 @default.
- W4366825877 hasIssue "4" @default.
- W4366825877 hasLocation W43668258771 @default.