Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366825891> ?p ?o ?g. }
- W4366825891 endingPage "1873" @default.
- W4366825891 startingPage "1857" @default.
- W4366825891 abstract "Abstract Prostate cancer (PCa), the second leading cause of death in American men, includes distinct genetic subtypes with distinct therapeutic vulnerabilities. The DACH1 gene encodes a winged helix/Forkhead DNA-binding protein that competes for binding to FOXM1 sites. Herein, DACH1 gene deletion within the 13q21.31-q21.33 region occurs in up to 18% of human PCa and was associated with increased AR activity and poor prognosis. In prostate OncoMice, prostate-specific deletion of the Dach1 gene enhanced prostatic intraepithelial neoplasia (PIN), and was associated with increased TGFβ activity and DNA damage. Reduced Dach1 increased DNA damage in response to genotoxic stresses. DACH1 was recruited to sites of DNA damage, augmenting recruitment of Ku70/Ku80. Reduced Dach1 expression was associated with increased homology directed repair and resistance to PARP inhibitors and TGFβ kinase inhibitors. Reduced Dach1 expression may define a subclass of PCa that warrants specific therapies." @default.
- W4366825891 created "2023-04-25" @default.
- W4366825891 creator A5006909847 @default.
- W4366825891 creator A5007862294 @default.
- W4366825891 creator A5008032475 @default.
- W4366825891 creator A5012659487 @default.
- W4366825891 creator A5014307132 @default.
- W4366825891 creator A5015102287 @default.
- W4366825891 creator A5015347383 @default.
- W4366825891 creator A5016235708 @default.
- W4366825891 creator A5017564926 @default.
- W4366825891 creator A5019100979 @default.
- W4366825891 creator A5022499603 @default.
- W4366825891 creator A5027970904 @default.
- W4366825891 creator A5029197376 @default.
- W4366825891 creator A5033125884 @default.
- W4366825891 creator A5034083243 @default.
- W4366825891 creator A5034205421 @default.
- W4366825891 creator A5050122863 @default.
- W4366825891 creator A5058022491 @default.
- W4366825891 creator A5058074251 @default.
- W4366825891 creator A5062939544 @default.
- W4366825891 creator A5065798455 @default.
- W4366825891 creator A5066344587 @default.
- W4366825891 creator A5075191661 @default.
- W4366825891 creator A5075248143 @default.
- W4366825891 creator A5080866337 @default.
- W4366825891 creator A5080940311 @default.
- W4366825891 creator A5082647263 @default.
- W4366825891 creator A5084386513 @default.
- W4366825891 creator A5086053207 @default.
- W4366825891 date "2023-04-24" @default.
- W4366825891 modified "2023-10-18" @default.
- W4366825891 title "The DACH1 gene is frequently deleted in prostate cancer, restrains prostatic intraepithelial neoplasia, decreases DNA damage repair, and predicts therapy responses" @default.
- W4366825891 cites W1972071622 @default.
- W4366825891 cites W1988671179 @default.
- W4366825891 cites W1995443324 @default.
- W4366825891 cites W2002576665 @default.
- W4366825891 cites W2003425522 @default.
- W4366825891 cites W2005472560 @default.
- W4366825891 cites W2007919127 @default.
- W4366825891 cites W2011957420 @default.
- W4366825891 cites W2020825769 @default.
- W4366825891 cites W2023461603 @default.
- W4366825891 cites W2025555587 @default.
- W4366825891 cites W2028371694 @default.
- W4366825891 cites W2032563591 @default.
- W4366825891 cites W2046240854 @default.
- W4366825891 cites W2050164541 @default.
- W4366825891 cites W2051025382 @default.
- W4366825891 cites W2052307676 @default.
- W4366825891 cites W2060310815 @default.
- W4366825891 cites W2063282456 @default.
- W4366825891 cites W2068668324 @default.
- W4366825891 cites W2072740522 @default.
- W4366825891 cites W2074737073 @default.
- W4366825891 cites W2080152855 @default.
- W4366825891 cites W2084541894 @default.
- W4366825891 cites W2086602305 @default.
- W4366825891 cites W2087688041 @default.
- W4366825891 cites W2093503215 @default.
- W4366825891 cites W2098203835 @default.
- W4366825891 cites W2100142491 @default.
- W4366825891 cites W2100508879 @default.
- W4366825891 cites W2104244846 @default.
- W4366825891 cites W2109197125 @default.
- W4366825891 cites W2109373293 @default.
- W4366825891 cites W2113047648 @default.
- W4366825891 cites W2114119899 @default.
- W4366825891 cites W2114843025 @default.
- W4366825891 cites W2115626825 @default.
- W4366825891 cites W2116144898 @default.
- W4366825891 cites W2117079802 @default.
- W4366825891 cites W2120633040 @default.
- W4366825891 cites W2121158863 @default.
- W4366825891 cites W2126411666 @default.
- W4366825891 cites W2126530170 @default.
- W4366825891 cites W2126597686 @default.
- W4366825891 cites W2127181594 @default.
- W4366825891 cites W2130728712 @default.
- W4366825891 cites W2132675424 @default.
- W4366825891 cites W2144267063 @default.
- W4366825891 cites W2146843027 @default.
- W4366825891 cites W2148416479 @default.
- W4366825891 cites W2151120233 @default.
- W4366825891 cites W2157852151 @default.
- W4366825891 cites W2161112598 @default.
- W4366825891 cites W2164900838 @default.
- W4366825891 cites W2169413646 @default.
- W4366825891 cites W2176840914 @default.
- W4366825891 cites W2228586054 @default.
- W4366825891 cites W2292362441 @default.
- W4366825891 cites W2408013527 @default.
- W4366825891 cites W2413931725 @default.
- W4366825891 cites W2462985846 @default.
- W4366825891 cites W2531696307 @default.
- W4366825891 cites W2545746388 @default.
- W4366825891 cites W2559051540 @default.