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- W4366827258 abstract "Despite the development of anti-myeloma therapeutics, such as proteasome inhibitors, immunomodulatory drugs, anti-CD38 monoclonal antibodies, and autologous stem cell transplantation (ASCT), multiple myeloma remains incurable. A trial treatment combining four drugs—daratumumab, carfilzomib, lenalidomide, and dexamethasone—followed by ASCT frequently results in minimal residual disease (MRD) negativity and prevents progressive disease in patients with standard- and high-risk cytogenetics; however, it is insufficient to overcome the poor outcomes in patients with ultra-high-risk chromosomal aberration (UHRCA). In fact, MRD status in autografts can predict clinical outcomes after ASCT. Therefore, the current treatment strategy might be insufficient to overcome the negative impact of UHRCA in patients with MRD positivity after the four-drug induction therapy. High-risk myeloma cells lead to poor clinical outcomes not only by aggressive myeloma behavior but also via the generation of a poor bone marrow microenvironment. Meanwhile, the immune microenvironment effectively suppresses myeloma cells with a low frequency of high-risk cytogenetic abnormalities in early-stage myeloma compared to late-stage myeloma. Therefore, early intervention might be key to improving clinical outcomes in myeloma patients. The purpose of this review is to improve clinical outcomes in patients with UHRCA by considering MRD assessment results and improvement of the microenvironment." @default.
- W4366827258 created "2023-04-25" @default.
- W4366827258 creator A5025950763 @default.
- W4366827258 creator A5082245729 @default.
- W4366827258 date "2023-04-22" @default.
- W4366827258 modified "2023-10-18" @default.
- W4366827258 title "Treatment Strategy for Ultra-High-Risk Multiple Myelomas with Chromosomal Aberrations Considering Minimal Residual Disease Status and Bone Marrow Microenvironment" @default.
- W4366827258 cites W1706760553 @default.
- W4366827258 cites W1747881616 @default.
- W4366827258 cites W1832162035 @default.
- W4366827258 cites W1922664920 @default.
- W4366827258 cites W1931964440 @default.
- W4366827258 cites W1959773306 @default.
- W4366827258 cites W1964309870 @default.
- W4366827258 cites W1978782811 @default.
- W4366827258 cites W1996819781 @default.
- W4366827258 cites W1997095405 @default.
- W4366827258 cites W1997831122 @default.
- W4366827258 cites W2004543856 @default.
- W4366827258 cites W2018475000 @default.
- W4366827258 cites W2025013606 @default.
- W4366827258 cites W2037484630 @default.
- W4366827258 cites W2056472648 @default.
- W4366827258 cites W2062404348 @default.
- W4366827258 cites W2083401403 @default.
- W4366827258 cites W2087973901 @default.
- W4366827258 cites W2088765731 @default.
- W4366827258 cites W2089902119 @default.
- W4366827258 cites W2104149194 @default.
- W4366827258 cites W2110648338 @default.
- W4366827258 cites W2124458344 @default.
- W4366827258 cites W2128192762 @default.
- W4366827258 cites W2131737708 @default.
- W4366827258 cites W2139260559 @default.
- W4366827258 cites W2142765738 @default.
- W4366827258 cites W2143425592 @default.
- W4366827258 cites W2144728882 @default.
- W4366827258 cites W2146382462 @default.
- W4366827258 cites W2152161793 @default.
- W4366827258 cites W2160088903 @default.
- W4366827258 cites W2170387305 @default.
- W4366827258 cites W2170842637 @default.
- W4366827258 cites W2201190784 @default.
- W4366827258 cites W2212499331 @default.
- W4366827258 cites W2345005763 @default.
- W4366827258 cites W2460207510 @default.
- W4366827258 cites W2486629951 @default.
- W4366827258 cites W2520654044 @default.
- W4366827258 cites W2525613924 @default.
- W4366827258 cites W2584063241 @default.
- W4366827258 cites W2592173429 @default.
- W4366827258 cites W2594388103 @default.
- W4366827258 cites W2594442364 @default.
- W4366827258 cites W2604776612 @default.
- W4366827258 cites W2618857260 @default.
- W4366827258 cites W2724736336 @default.
- W4366827258 cites W2741518036 @default.
- W4366827258 cites W2755732362 @default.
- W4366827258 cites W2766055333 @default.
- W4366827258 cites W2781246278 @default.
- W4366827258 cites W2793076498 @default.
- W4366827258 cites W2799462831 @default.
- W4366827258 cites W2801500536 @default.
- W4366827258 cites W2803417376 @default.
- W4366827258 cites W2805293188 @default.
- W4366827258 cites W2806277057 @default.
- W4366827258 cites W2809698015 @default.
- W4366827258 cites W2886837533 @default.
- W4366827258 cites W2888510276 @default.
- W4366827258 cites W2893245372 @default.
- W4366827258 cites W2898329514 @default.
- W4366827258 cites W2900068404 @default.
- W4366827258 cites W2901697104 @default.
- W4366827258 cites W2902162324 @default.
- W4366827258 cites W2904294860 @default.
- W4366827258 cites W2905233176 @default.
- W4366827258 cites W2909137860 @default.
- W4366827258 cites W2913092224 @default.
- W4366827258 cites W2920164876 @default.
- W4366827258 cites W2923396001 @default.
- W4366827258 cites W2943335541 @default.
- W4366827258 cites W2947708728 @default.
- W4366827258 cites W2953981972 @default.
- W4366827258 cites W2962324833 @default.
- W4366827258 cites W2964931238 @default.
- W4366827258 cites W2977425571 @default.
- W4366827258 cites W2980601466 @default.
- W4366827258 cites W2990865799 @default.
- W4366827258 cites W2995934717 @default.
- W4366827258 cites W2996228708 @default.
- W4366827258 cites W3009554897 @default.
- W4366827258 cites W3018331841 @default.
- W4366827258 cites W3021098306 @default.
- W4366827258 cites W3021432759 @default.
- W4366827258 cites W3027800687 @default.
- W4366827258 cites W3029080165 @default.
- W4366827258 cites W3031337047 @default.
- W4366827258 cites W3032142108 @default.