Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366973446> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4366973446 endingPage "19" @default.
- W4366973446 startingPage "11" @default.
- W4366973446 abstract "Introduction: Pioglitazone (PG) which belongs to thiazolidinedione class is a drug used in the treatment of type 2 diabetes. PG increases the insulin sensitivity of peripheral tissues. Type 2 diabetes mellitus (T2DM) is one of the most common and fastest developing diseases. The antihyperglycemic effect of pioglitazone (PG) is not its only one. This drug has a number of other metabolically beneficial effects. Many outcome trials indicate a positive impact of PG on the functioning of other systems.
 Aim of the study: The aim of this study is to summarize the current knowledge on the effectiveness and safety of pioglitazone based on the available scientific literature.
 Materials and methods: Literature review based on PubMed, Google Scholar database using the following phrases: pioglitazone, type 2 diabetes, pioglitazone in non-alcoholic fatty liver disease (NAFLD) therapy, pioglitazone and cardiovascular risk, pioglitazone nephroprotective effect, pioglitazone safety profile.
 State of knowledge: Pioglitazone is an oral antidiabetic drug used in the therapy of T2DM. PG belongs to the ‘insulin- sensitizers’. It is included in the treatment in the case of intolerance, contraindications to metformin or as part of combination therapy.
 Conclusions: Recently, interest in pioglitazone has waned due to the perception of significant side effects. The analysis of the papers showed a positive effect of PG on the cardiovascular system, central nervous system, NAFLD and nephroprotection. The acceptable safety profile of pioglitazone with the appropriate selection of patients as well as its multidirectional action and effectiveness mean that clinicians should reconsider the use of this drug guided by the balance of profits and losses." @default.
- W4366973446 created "2023-04-27" @default.
- W4366973446 creator A5049535890 @default.
- W4366973446 creator A5060133685 @default.
- W4366973446 date "2023-04-25" @default.
- W4366973446 modified "2023-10-14" @default.
- W4366973446 title "Pioglitazone - the forgotten drug with multidirectional action" @default.
- W4366973446 doi "https://doi.org/10.12775/jehs.2023.24.01.001" @default.
- W4366973446 hasPublicationYear "2023" @default.
- W4366973446 type Work @default.
- W4366973446 citedByCount "0" @default.
- W4366973446 crossrefType "journal-article" @default.
- W4366973446 hasAuthorship W4366973446A5049535890 @default.
- W4366973446 hasAuthorship W4366973446A5060133685 @default.
- W4366973446 hasBestOaLocation W43669734461 @default.
- W4366973446 hasConcept C126322002 @default.
- W4366973446 hasConcept C134018914 @default.
- W4366973446 hasConcept C2776923340 @default.
- W4366973446 hasConcept C2777180221 @default.
- W4366973446 hasConcept C2778384471 @default.
- W4366973446 hasConcept C2779306644 @default.
- W4366973446 hasConcept C2780035454 @default.
- W4366973446 hasConcept C2780323712 @default.
- W4366973446 hasConcept C2910068830 @default.
- W4366973446 hasConcept C535046627 @default.
- W4366973446 hasConcept C555293320 @default.
- W4366973446 hasConcept C71924100 @default.
- W4366973446 hasConcept C98274493 @default.
- W4366973446 hasConceptScore W4366973446C126322002 @default.
- W4366973446 hasConceptScore W4366973446C134018914 @default.
- W4366973446 hasConceptScore W4366973446C2776923340 @default.
- W4366973446 hasConceptScore W4366973446C2777180221 @default.
- W4366973446 hasConceptScore W4366973446C2778384471 @default.
- W4366973446 hasConceptScore W4366973446C2779306644 @default.
- W4366973446 hasConceptScore W4366973446C2780035454 @default.
- W4366973446 hasConceptScore W4366973446C2780323712 @default.
- W4366973446 hasConceptScore W4366973446C2910068830 @default.
- W4366973446 hasConceptScore W4366973446C535046627 @default.
- W4366973446 hasConceptScore W4366973446C555293320 @default.
- W4366973446 hasConceptScore W4366973446C71924100 @default.
- W4366973446 hasConceptScore W4366973446C98274493 @default.
- W4366973446 hasIssue "1" @default.
- W4366973446 hasLocation W43669734461 @default.
- W4366973446 hasLocation W43669734462 @default.
- W4366973446 hasOpenAccess W4366973446 @default.
- W4366973446 hasPrimaryLocation W43669734461 @default.
- W4366973446 hasRelatedWork W1492715899 @default.
- W4366973446 hasRelatedWork W1575015987 @default.
- W4366973446 hasRelatedWork W2013280207 @default.
- W4366973446 hasRelatedWork W2035838062 @default.
- W4366973446 hasRelatedWork W2113209045 @default.
- W4366973446 hasRelatedWork W2472444237 @default.
- W4366973446 hasRelatedWork W2556250268 @default.
- W4366973446 hasRelatedWork W2599384821 @default.
- W4366973446 hasRelatedWork W4367476584 @default.
- W4366973446 hasRelatedWork W51281832 @default.
- W4366973446 hasVolume "24" @default.
- W4366973446 isParatext "false" @default.
- W4366973446 isRetracted "false" @default.
- W4366973446 workType "article" @default.