FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366977067> ?p ?o ?g. }

• W4366977067 abstract "Background Large metastatic lesions of the diaphysis can cause considerable pain and result in difficult surgical challenges. Resection and cemented intercalary endoprosthetic reconstruction offer one solution to the problem, but it is an extensive operation that might not be tolerated well by a debilitated patient. The risk of aseptic loosening and revision after intercalary endoprosthetic replacement has varied in previous reports, which have not examined the risk of revision in the context of patient survival. Questions/purposes (1) In a small case series from one institution, what is the survivorship of patients after cemented intercalary endoprosthetic replacement for diaphyseal metastasis, and what is the cumulative incidence of revision for any reason? (2) What are the complications associated with cemented intercalary reconstruction? (3) What is the functional outcome after the procedure as assessed by the MSTS93 score? Methods We retrospectively studied 19 patients with diaphyseal long bone metastases who were treated with resection and cemented intercalary endoprosthetic reconstruction by five participating surgeons at one referral center from 2006 to 2017. There were 11 men and eight women with a median age of 59 years (range 46 to 80 years). The minimum follow-up required for this series was 12 months; however, patients who reached an endpoint (death, radiographic loosening, or implant revision) before that time were included. One of these 19 patients was lost to follow-up but was not known to have died. The median follow-up was 24 months (range 0 to 116 months). Eight of the 19 patients presented with pathologic fractures. Ten of 19 lesions involved the femur, and nine of 19 were in the humerus. The most common pathologic finding was renal cell carcinoma (in 10 of 19). Survival estimates of the patients were calculated using the Kaplan-Meier method. A competing risks estimator was used to evaluate implant survival, using death of the patient as the competing risk. We also estimated the cumulative incidence of aseptic loosening in a competing risk analysis. Radiographs were analyzed for radiolucency at the bone-cement-implant interfaces, fracture, integrity of the cement mantle, and component position stability. Complications were assessed using record review that was performed by an individual who was not involved in the initial care of the patients. Functional outcomes were assessed using the MSTS93 scoring system. Results Patient survivorship was 68% (95% CI 50% to 93%) at 1 year, 53% (95% CI 34% to 81%) at 2 years, and 14% (95% CI 4% to 49%) at 5 years; the median patient survival time after reconstruction was 25 months (range 0 to 116 months). In the competing risk analysis, using death as the competing risk, the cumulative incidence of implant revision was 11% (95% CI 2% to 29%) at 1 year and 16% (95% CI 4% to 36%) at 5 years after surgery; however, the cumulative incidence of aseptic loosening (with death as a competing risk) was 22% (95% CI 6% to 43%) at 1 year and 33% (95% CI 13% to 55%) at 5 years after surgery. Other complications included one patient who died postoperatively of cardiac arrest, one patient with delayed wound healing, two patients with bone recurrence, and one patient who experienced local soft tissue recurrence that was excised without implant revision. Total MSTS93 scores improved from a mean of 12.6 ± 8.1 (42% ± 27%) preoperatively to 21.5 ± 5.0 (72% ± 17%) at 3 months postoperatively (p < 0.001) and 21.6 ± 8.5 (72% ± 28%) at 2 years postoperatively (p = 0.98; 3 months versus 2 years). Conclusion Resection of diaphyseal metastases with intercalary reconstruction can provide stability and short-term improvement in function for patients with advanced metastatic disease and extensive cortical destruction. Aseptic loosening is a concern, particularly in the humerus; however, the competing risk analysis suggests the procedure is adequate for most patients, because many in this series died of disease without undergoing revision. Level of Evidence Level IV, therapeutic study." @default.
• W4366977067 created "2023-04-27" @default.
• W4366977067 creator A5010680197 @default.
• W4366977067 creator A5021423770 @default.
• W4366977067 creator A5023910969 @default.
• W4366977067 creator A5039778886 @default.
• W4366977067 creator A5056438282 @default.
• W4366977067 creator A5056906070 @default.
• W4366977067 creator A5062243847 @default.
• W4366977067 date "2023-04-25" @default.
• W4366977067 modified "2023-10-14" @default.
• W4366977067 title "What Is the Prosthetic Survival After Resection and Intercalary Endoprosthetic Reconstruction for Diaphyseal Bone Metastases of the Humerus and Femur?" @default.
• W4366977067 cites W1976676803 @default.
• W4366977067 cites W1989843965 @default.
• W4366977067 cites W2023023124 @default.
• W4366977067 cites W2034626806 @default.
• W4366977067 cites W2041707433 @default.
• W4366977067 cites W2062823418 @default.
• W4366977067 cites W2097856129 @default.
• W4366977067 cites W2104360482 @default.
• W4366977067 cites W2136454327 @default.
• W4366977067 cites W2186876643 @default.
• W4366977067 cites W2345478622 @default.
• W4366977067 cites W2621542226 @default.
• W4366977067 cites W2623596506 @default.
• W4366977067 cites W2803648813 @default.
• W4366977067 cites W2897583970 @default.
• W4366977067 cites W2955211517 @default.
• W4366977067 cites W3092251352 @default.
• W4366977067 cites W3159798529 @default.
• W4366977067 cites W3195143732 @default.
• W4366977067 cites W4376595646 @default.
• W4366977067 doi "https://doi.org/10.1097/corr.0000000000002669" @default.
• W4366977067 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37185204" @default.
• W4366977067 hasPublicationYear "2023" @default.
• W4366977067 type Work @default.
• W4366977067 citedByCount "1" @default.
• W4366977067 countsByYear W43669770672023 @default.
• W4366977067 crossrefType "journal-article" @default.
• W4366977067 hasAuthorship W4366977067A5010680197 @default.
• W4366977067 hasAuthorship W4366977067A5021423770 @default.
• W4366977067 hasAuthorship W4366977067A5023910969 @default.
• W4366977067 hasAuthorship W4366977067A5039778886 @default.
• W4366977067 hasAuthorship W4366977067A5056438282 @default.
• W4366977067 hasAuthorship W4366977067A5056906070 @default.
• W4366977067 hasAuthorship W4366977067A5062243847 @default.
• W4366977067 hasConcept C141071460 @default.
• W4366977067 hasConcept C142724271 @default.
• W4366977067 hasConcept C151730666 @default.
• W4366977067 hasConcept C204787440 @default.
• W4366977067 hasConcept C2776206872 @default.
• W4366977067 hasConcept C2776494729 @default.
• W4366977067 hasConcept C2778951355 @default.
• W4366977067 hasConcept C2779343474 @default.
• W4366977067 hasConcept C2780554211 @default.
• W4366977067 hasConcept C36454342 @default.
• W4366977067 hasConcept C68312169 @default.
• W4366977067 hasConcept C71924100 @default.
• W4366977067 hasConcept C86803240 @default.
• W4366977067 hasConceptScore W4366977067C141071460 @default.
• W4366977067 hasConceptScore W4366977067C142724271 @default.
• W4366977067 hasConceptScore W4366977067C151730666 @default.
• W4366977067 hasConceptScore W4366977067C204787440 @default.
• W4366977067 hasConceptScore W4366977067C2776206872 @default.
• W4366977067 hasConceptScore W4366977067C2776494729 @default.
• W4366977067 hasConceptScore W4366977067C2778951355 @default.
• W4366977067 hasConceptScore W4366977067C2779343474 @default.
• W4366977067 hasConceptScore W4366977067C2780554211 @default.
• W4366977067 hasConceptScore W4366977067C36454342 @default.
• W4366977067 hasConceptScore W4366977067C68312169 @default.
• W4366977067 hasConceptScore W4366977067C71924100 @default.
• W4366977067 hasConceptScore W4366977067C86803240 @default.
• W4366977067 hasLocation W43669770671 @default.
• W4366977067 hasLocation W43669770672 @default.
• W4366977067 hasOpenAccess W4366977067 @default.
• W4366977067 hasPrimaryLocation W43669770671 @default.
• W4366977067 hasRelatedWork W1993654618 @default.
• W4366977067 hasRelatedWork W2084388835 @default.
• W4366977067 hasRelatedWork W2086100141 @default.
• W4366977067 hasRelatedWork W2105881028 @default.
• W4366977067 hasRelatedWork W2161074011 @default.
• W4366977067 hasRelatedWork W2400811273 @default.
• W4366977067 hasRelatedWork W2406821141 @default.
• W4366977067 hasRelatedWork W2433633411 @default.
• W4366977067 hasRelatedWork W2781622149 @default.
• W4366977067 hasRelatedWork W3185089278 @default.
• W4366977067 hasVolume "Publish Ahead of Print" @default.
• W4366977067 isParatext "false" @default.
• W4366977067 isRetracted "false" @default.
• W4366977067 workType "article" @default.