FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366978078> ?p ?o ?g. }

• W4366978078 endingPage "471" @default.
• W4366978078 startingPage "467" @default.
• W4366978078 abstract "Lowering intraocular pressure (IOP) is a mainstay of glaucoma therapy. It is, however, still an open question whether a comparable level of long-term IOP lowering achieved by different medications results in comparable protection for the retinal ganglion cells. The purpose of this study was to retrospectively analyze glaucoma damage progression in two cohorts of primary open-angle glaucoma patients with different and unchanged therapy over a period of 3 years, and the main objective of this study was to determine possible differences in terms of structural [retinal nerve fiber layer thickness (RNFL)] and functional [visual field (VF)] outcome.The retrospective observational cohort analysis compared two differently treated groups of glaucoma patients with their original, at study entry, topical therapy unchanged over 3 years. The main endpoint was the time course of RNFL thickness and VF mean defect (MD).Twenty-one eyes were included in each group. The first group (21 eyes) was on a fixed combination of timolol and dorzolamide twice a day and the second group on one drop of prostaglandin analog, either latanoprost alone (15 eyes) or travoprost alone (6 eyes), in an unchanged regimen over a period of 3 years. IOP in mmHg at baseline and at 36 months was 11.9 ± 2.4 and 13.0 ± 2.1 in the first, and 12.9 ± 3.0 and 14.1 ± 3.2 in the second group, respectively. RNFL thickness values in micrometers were at baseline and at 36 months 77.8 ± 12.3 and 76.6 ± 15.2 in the first, and 77.5 ± 15.2 and 72.8 ± 14.5 in the second group, respectively. VF MD in dB were 1.7 ± 2.5 and 1.2 ± 2.9 in the first, and 0.9 ± 2.3 and 0.7 ± 2.6 in the second group, respectively.Both groups had comparable baseline, as well as mean overall IOP. However, the course of IOP levels over time was different in the two groups, showing earlier and more pronounced long-term drift in the prostaglandin analog-treated group. RNFL thickness was comparable at baseline, however, RNFL thinning over time was more pronounced in the prostaglandin analog-treated group. There were no statistical differences between the groups in terms of VF MD at baseline and over time.Bei der Therapie von Glaukompatienten stellt sich immer noch die Frage, ob ein vergleichbares Niveau der langfristigen IOD-Senkung durch verschiedene Medikamente zu einem vergleichbaren Schutz der retinalen Ganglienzellen führt. Wir verglichen in dieser retrospektiven Analyse zwei Kohorten von Patienten mit primärem Offenwinkelglaukom mit unterschiedlicher und unveränderter medikamentösen Therapie über einen Zeitraum von drei Jahren. Bei vergleichbarem mittleren Gesamtdruck zeigte sich zwar kein signifikant unterschiedlicher Verlauf des Gesichtsfeldes, jedoch ein signifikant unterschiedlicher Verlauf der Retinalen Nervenfaserschichtdicke." @default.
• W4366978078 created "2023-04-27" @default.
• W4366978078 creator A5004084769 @default.
• W4366978078 creator A5022460974 @default.
• W4366978078 creator A5091323230 @default.
• W4366978078 date "2023-04-01" @default.
• W4366978078 modified "2023-09-25" @default.
• W4366978078 title "Primary Open-Angle Glaucoma Progression in Glaucoma Patients with Unchanged Topical Treatment over 3 Years – Retrospective Observational Cohort Analysis" @default.
• W4366978078 cites W1972999008 @default.
• W4366978078 cites W1986128758 @default.
• W4366978078 cites W1994400821 @default.
• W4366978078 cites W1997235887 @default.
• W4366978078 cites W2009962222 @default.
• W4366978078 cites W2040644603 @default.
• W4366978078 cites W2044911144 @default.
• W4366978078 cites W2056397917 @default.
• W4366978078 cites W2068802303 @default.
• W4366978078 cites W2110897487 @default.
• W4366978078 cites W2131914037 @default.
• W4366978078 cites W2147093603 @default.
• W4366978078 cites W2147656527 @default.
• W4366978078 cites W2185914194 @default.
• W4366978078 cites W2305697911 @default.
• W4366978078 cites W2970838726 @default.
• W4366978078 cites W2977587116 @default.
• W4366978078 doi "https://doi.org/10.1055/a-2004-4943" @default.
• W4366978078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37164404" @default.
• W4366978078 hasPublicationYear "2023" @default.
• W4366978078 type Work @default.
• W4366978078 citedByCount "0" @default.
• W4366978078 crossrefType "journal-article" @default.
• W4366978078 hasAuthorship W4366978078A5004084769 @default.
• W4366978078 hasAuthorship W4366978078A5022460974 @default.
• W4366978078 hasAuthorship W4366978078A5091323230 @default.
• W4366978078 hasConcept C118487528 @default.
• W4366978078 hasConcept C141071460 @default.
• W4366978078 hasConcept C167135981 @default.
• W4366978078 hasConcept C168563851 @default.
• W4366978078 hasConcept C203092338 @default.
• W4366978078 hasConcept C2776727336 @default.
• W4366978078 hasConcept C2776740260 @default.
• W4366978078 hasConcept C2777336333 @default.
• W4366978078 hasConcept C2778073030 @default.
• W4366978078 hasConcept C2778527774 @default.
• W4366978078 hasConcept C2780276452 @default.
• W4366978078 hasConcept C2780827179 @default.
• W4366978078 hasConcept C2781092963 @default.
• W4366978078 hasConcept C2991803831 @default.
• W4366978078 hasConcept C71924100 @default.
• W4366978078 hasConceptScore W4366978078C118487528 @default.
• W4366978078 hasConceptScore W4366978078C141071460 @default.
• W4366978078 hasConceptScore W4366978078C167135981 @default.
• W4366978078 hasConceptScore W4366978078C168563851 @default.
• W4366978078 hasConceptScore W4366978078C203092338 @default.
• W4366978078 hasConceptScore W4366978078C2776727336 @default.
• W4366978078 hasConceptScore W4366978078C2776740260 @default.
• W4366978078 hasConceptScore W4366978078C2777336333 @default.
• W4366978078 hasConceptScore W4366978078C2778073030 @default.
• W4366978078 hasConceptScore W4366978078C2778527774 @default.
• W4366978078 hasConceptScore W4366978078C2780276452 @default.
• W4366978078 hasConceptScore W4366978078C2780827179 @default.
• W4366978078 hasConceptScore W4366978078C2781092963 @default.
• W4366978078 hasConceptScore W4366978078C2991803831 @default.
• W4366978078 hasConceptScore W4366978078C71924100 @default.
• W4366978078 hasIssue "04" @default.
• W4366978078 hasLocation W43669780781 @default.
• W4366978078 hasLocation W43669780782 @default.
• W4366978078 hasOpenAccess W4366978078 @default.
• W4366978078 hasPrimaryLocation W43669780781 @default.
• W4366978078 hasRelatedWork W164455875 @default.
• W4366978078 hasRelatedWork W1966103856 @default.
• W4366978078 hasRelatedWork W1988307533 @default.
• W4366978078 hasRelatedWork W2010755453 @default.
• W4366978078 hasRelatedWork W2065005955 @default.
• W4366978078 hasRelatedWork W2098532635 @default.
• W4366978078 hasRelatedWork W2106674716 @default.
• W4366978078 hasRelatedWork W2128476364 @default.
• W4366978078 hasRelatedWork W2316224317 @default.
• W4366978078 hasRelatedWork W3008326380 @default.
• W4366978078 hasVolume "240" @default.
• W4366978078 isParatext "false" @default.
• W4366978078 isRetracted "false" @default.
• W4366978078 workType "article" @default.