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- W4366979995 abstract "Poly (ADP-ribose)-polymerases (PARPs) play an essential role in the maintenance of genome integrity, DNA repair, and apoptosis. PARP inhibitors (PARPi) exert antitumor effects via synthetic lethality and PARP trapping. PARPi impact the antitumor immune response by modulating the tumor microenvironment, and their effect has dual properties of promoting and inhibiting the antitumor immune response. PARPi promote M1 macrophage polarization, antigen presentation by dendritic cells, infiltration of B and T cells and their killing capacity and inhibit tumor angiogenesis. PARPi can also inhibit the activation and function of immune cells by upregulating PD-L1. In this review, we summarize the dual immunomodulatory effects and possible underlying mechanisms of PARPi, providing a basis for the design of combination regimens for clinical treatment and the identification of populations who may benefit from these therapies." @default.
- W4366979995 created "2023-04-27" @default.
- W4366979995 creator A5012757139 @default.
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- W4366979995 creator A5073294274 @default.
- W4366979995 date "2023-07-01" @default.
- W4366979995 modified "2023-10-14" @default.
- W4366979995 title "Dual antitumor immunomodulatory effects of PARP inhibitor on the tumor microenvironment: A counterbalance between anti-tumor and pro-tumor" @default.
- W4366979995 cites W1045337831 @default.
- W4366979995 cites W1506161763 @default.
- W4366979995 cites W1510735640 @default.
- W4366979995 cites W1567364673 @default.
- W4366979995 cites W1971745781 @default.
- W4366979995 cites W1972564604 @default.
- W4366979995 cites W1973201987 @default.
- W4366979995 cites W1974916823 @default.
- W4366979995 cites W1981326797 @default.
- W4366979995 cites W1986810494 @default.
- W4366979995 cites W1987313116 @default.
- W4366979995 cites W1991129425 @default.
- W4366979995 cites W1992112921 @default.
- W4366979995 cites W1998727638 @default.
- W4366979995 cites W1998862888 @default.
- W4366979995 cites W1999450280 @default.
- W4366979995 cites W2001222940 @default.
- W4366979995 cites W2001387281 @default.
- W4366979995 cites W2004067791 @default.
- W4366979995 cites W2005749687 @default.
- W4366979995 cites W2006885289 @default.
- W4366979995 cites W2009007206 @default.
- W4366979995 cites W2009812837 @default.
- W4366979995 cites W2012049551 @default.
- W4366979995 cites W2016164706 @default.
- W4366979995 cites W2019383774 @default.
- W4366979995 cites W2022540958 @default.
- W4366979995 cites W2023279756 @default.
- W4366979995 cites W2024222442 @default.
- W4366979995 cites W2027904894 @default.
- W4366979995 cites W2031913686 @default.
- W4366979995 cites W2037250871 @default.
- W4366979995 cites W2037943855 @default.
- W4366979995 cites W2038781914 @default.
- W4366979995 cites W2039171346 @default.
- W4366979995 cites W2039181519 @default.
- W4366979995 cites W2040971700 @default.
- W4366979995 cites W2045620095 @default.
- W4366979995 cites W2047958526 @default.
- W4366979995 cites W2052825248 @default.
- W4366979995 cites W2053985534 @default.
- W4366979995 cites W2063725583 @default.
- W4366979995 cites W2065103997 @default.
- W4366979995 cites W2065434335 @default.
- W4366979995 cites W2066039014 @default.
- W4366979995 cites W2068367973 @default.
- W4366979995 cites W2070758111 @default.
- W4366979995 cites W2072451175 @default.
- W4366979995 cites W2072528578 @default.
- W4366979995 cites W2079891276 @default.
- W4366979995 cites W2080666790 @default.
- W4366979995 cites W2082618949 @default.
- W4366979995 cites W2083960841 @default.
- W4366979995 cites W2085381534 @default.
- W4366979995 cites W2102047778 @default.
- W4366979995 cites W2103021272 @default.
- W4366979995 cites W2104425537 @default.
- W4366979995 cites W2109690762 @default.
- W4366979995 cites W2111365327 @default.
- W4366979995 cites W2111420919 @default.
- W4366979995 cites W2111667552 @default.
- W4366979995 cites W2112740421 @default.
- W4366979995 cites W2117692326 @default.
- W4366979995 cites W2118211359 @default.
- W4366979995 cites W2123588904 @default.
- W4366979995 cites W2125663719 @default.
- W4366979995 cites W2127733313 @default.
- W4366979995 cites W2131464730 @default.
- W4366979995 cites W2131556221 @default.
- W4366979995 cites W2132324298 @default.
- W4366979995 cites W2137530154 @default.
- W4366979995 cites W2138922715 @default.
- W4366979995 cites W2139802796 @default.
- W4366979995 cites W2140551998 @default.
- W4366979995 cites W2140948050 @default.
- W4366979995 cites W2145200068 @default.
- W4366979995 cites W2146604395 @default.
- W4366979995 cites W2150089707 @default.
- W4366979995 cites W2160973157 @default.
- W4366979995 cites W2161708429 @default.
- W4366979995 cites W2164995160 @default.
- W4366979995 cites W2173456459 @default.
- W4366979995 cites W2177072498 @default.
- W4366979995 cites W2237126693 @default.
- W4366979995 cites W2252550602 @default.