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• W4366984902 abstract "Abstract Background Previous studies discovered the presence of abnormal structures and functions in the brain regions of patients with obsessive-compulsive disorder (OCD). Nevertheless, whether structural changes in brain regions are coupled with alterations in dynamic functional connectivity (dFC) at rest in medicine-free patients with OCD remains vague. Methods Three-dimensional T 1 -weighed magnetic resonance imaging (MRI) and resting-state functional MRI were performed on 50 medicine-free OCD and 50 healthy controls (HCs). Firstly, the differences in gray matter volume (GMV) between OCD and HCs were compared. Then, brain regions with aberrant GMV were used as seeds for dFC analysis. The relationship of altered GMV and dFC with clinical parameters in OCD was explored using partial correlation analysis. Finally, support vector machine was applied to examine whether altered multimodal imaging data might be adopted to distinguish OCD from HCs. Results Our findings indicated that GMV in the left superior temporal gyrus (STG) and right supplementary motor area (SMA) was reduced in OCD, and the dFC between the left STG and the left cerebellum Crus I and left thalamus, and between the right SMA and right dorsolateral prefrontal cortex (DLPFC) and left precuneus was decreased at rest in OCD. The brain regions both with altered GMV and dFC values could discriminate OCD from HCs with the accuracy of 0.85, sensitivity of 0.90 and specificity of 0.80. Conclusion The decreased gray matter structure coupling with dynamic function in the left STG and right SMA at rest may be crucial in the pathophysiology of OCD. Trial registration Study on the mechanism of brain network in obsessive-compulsive disorder with multi-model magnetic resonance imaging (registration date: 08/11/2017; registration number: ChiCTR-COC-17,013,301)." @default.
• W4366984902 created "2023-04-27" @default.
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• W4366984902 date "2023-04-25" @default.
• W4366984902 modified "2023-10-14" @default.
• W4366984902 title "Decreased gray matter volume and dynamic functional alterations in medicine-free obsessive-compulsive disorder" @default.
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• W4366984902 doi "https://doi.org/10.1186/s12888-023-04740-w" @default.
• W4366984902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37098479" @default.
• W4366984902 hasPublicationYear "2023" @default.
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