Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366985666> ?p ?o ?g. }
- W4366985666 abstract "The study of breathing in fishes has featured prominently in Journal of Experimental Biology (JEB), particularly during the latter half of the past century. Indeed, many of the seminal discoveries in this important sub-field of comparative respiratory physiology were reported first in JEB. The period spanning 1960-1990 (the 'golden age of comparative respiratory physiology') witnessed intense innovation in the development of methods to study the control of breathing. Many of the guiding principles of piscine ventilatory control originated during this period, including our understanding of the dominance of O2 as the driver of ventilation in fish. However, a critical issue - the identity of the peripheral O2 chemoreceptors - remained unanswered until methods for cell isolation, culture and patch-clamp recording established that gill neuroepithelial cells (NECs) respond to hypoxia in vitro. Yet, the role of the NECs and other putative peripheral or central chemoreceptors in the control of ventilation in vivo remains poorly understood. Further progress will be driven by the implementation of genetic tools, most of which can be used in zebrafish (Danio rerio). These tools include CRISPR/Cas9 for selective gene knockout, and Tol2 systems for transgenesis, the latter of which enables optogenetic stimulation of cellular pathways, cellular ablation and in vivo cell-specific biosensing. Using these methods, the next period of discovery will see the identification of the peripheral sensory pathways that initiate ventilatory responses, and will elucidate the nature of their integration within the central nervous system and their link to the efferent motor neurons that control breathing." @default.
- W4366985666 created "2023-04-27" @default.
- W4366985666 creator A5003027778 @default.
- W4366985666 creator A5028844049 @default.
- W4366985666 date "2023-04-15" @default.
- W4366985666 modified "2023-10-18" @default.
- W4366985666 title "The control of breathing in fishes – historical perspectives and the path ahead" @default.
- W4366985666 cites W104220302 @default.
- W4366985666 cites W1483013858 @default.
- W4366985666 cites W1513886440 @default.
- W4366985666 cites W1526183158 @default.
- W4366985666 cites W1829228176 @default.
- W4366985666 cites W1904716252 @default.
- W4366985666 cites W1943283541 @default.
- W4366985666 cites W1956171442 @default.
- W4366985666 cites W1965965325 @default.
- W4366985666 cites W1971320703 @default.
- W4366985666 cites W1976436947 @default.
- W4366985666 cites W1976622266 @default.
- W4366985666 cites W1980828912 @default.
- W4366985666 cites W1981986399 @default.
- W4366985666 cites W1982306653 @default.
- W4366985666 cites W1986136618 @default.
- W4366985666 cites W1987235037 @default.
- W4366985666 cites W1993763565 @default.
- W4366985666 cites W1996241703 @default.
- W4366985666 cites W1997020876 @default.
- W4366985666 cites W2001889043 @default.
- W4366985666 cites W2005396839 @default.
- W4366985666 cites W2007506265 @default.
- W4366985666 cites W2009498172 @default.
- W4366985666 cites W2009888432 @default.
- W4366985666 cites W2012640614 @default.
- W4366985666 cites W2014001473 @default.
- W4366985666 cites W2014118841 @default.
- W4366985666 cites W2019570803 @default.
- W4366985666 cites W2019751519 @default.
- W4366985666 cites W2021716195 @default.
- W4366985666 cites W2024146841 @default.
- W4366985666 cites W2024608742 @default.
- W4366985666 cites W2026020780 @default.
- W4366985666 cites W2029781435 @default.
- W4366985666 cites W2034058832 @default.
- W4366985666 cites W2037200881 @default.
- W4366985666 cites W2040560187 @default.
- W4366985666 cites W2053873652 @default.
- W4366985666 cites W2055543979 @default.
- W4366985666 cites W2061478333 @default.
- W4366985666 cites W2063353346 @default.
- W4366985666 cites W2063407529 @default.
- W4366985666 cites W2069508360 @default.
- W4366985666 cites W2074617533 @default.
- W4366985666 cites W2075449833 @default.
- W4366985666 cites W2075627078 @default.
- W4366985666 cites W2078863293 @default.
- W4366985666 cites W2082010815 @default.
- W4366985666 cites W2087196474 @default.
- W4366985666 cites W2096543061 @default.
- W4366985666 cites W2099791270 @default.
- W4366985666 cites W2106798308 @default.
- W4366985666 cites W2110643873 @default.
- W4366985666 cites W2110767065 @default.
- W4366985666 cites W2111889519 @default.
- W4366985666 cites W2116288207 @default.
- W4366985666 cites W2119133623 @default.
- W4366985666 cites W2119414196 @default.
- W4366985666 cites W2128618698 @default.
- W4366985666 cites W2132391399 @default.
- W4366985666 cites W2133814656 @default.
- W4366985666 cites W2139472025 @default.
- W4366985666 cites W2140671179 @default.
- W4366985666 cites W2145434546 @default.
- W4366985666 cites W2147332671 @default.
- W4366985666 cites W2148347681 @default.
- W4366985666 cites W2150335345 @default.
- W4366985666 cites W2151956257 @default.
- W4366985666 cites W2154825448 @default.
- W4366985666 cites W2158692689 @default.
- W4366985666 cites W2168890118 @default.
- W4366985666 cites W2171332611 @default.
- W4366985666 cites W2181781193 @default.
- W4366985666 cites W2182717512 @default.
- W4366985666 cites W2186048441 @default.
- W4366985666 cites W2188885344 @default.
- W4366985666 cites W2243319761 @default.
- W4366985666 cites W2274104496 @default.
- W4366985666 cites W2283780809 @default.
- W4366985666 cites W2291957660 @default.
- W4366985666 cites W2306941641 @default.
- W4366985666 cites W2312799695 @default.
- W4366985666 cites W2313163172 @default.
- W4366985666 cites W2313553537 @default.
- W4366985666 cites W2318106204 @default.
- W4366985666 cites W2326469953 @default.
- W4366985666 cites W2341260387 @default.
- W4366985666 cites W2441354505 @default.
- W4366985666 cites W2466477639 @default.
- W4366985666 cites W2474258586 @default.
- W4366985666 cites W2516314843 @default.
- W4366985666 cites W2522769808 @default.