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• W4366985722 endingPage "1333" @default.
• W4366985722 startingPage "1322" @default.
• W4366985722 abstract "Noninvasive recordings of motor unit (MU) spike trains help us understand how the nervous system controls movement and how it adapts to various physiological conditions. The majority of participants in human and nonhuman animal physiology studies are male, and it is assumed that mechanisms uncovered in these studies are shared between males and females. However, sex differences in neurological impairment and physical performance warrant the study of sex as a biological variable in human physiology and performance. To begin addressing this gap in the study of biophysical properties of human motoneurons, we quantified MU discharge rates and estimates of persistent inward current (PIC) magnitude in both sexes. We decomposed MU spike trains from the tibialis anterior (TA), medial gastrocnemius (MG), and soleus (SOL) using high-density surface electromyography and blind source separation algorithms. Ten participants of each sex performed slow triangular (10 s up and down) isometric contractions to a peak of 30% of their maximum voluntary contraction. We then used linear mixed-effects models to determine if peak discharge rate and estimates of PICs were predicted by the fixed effects of sex, muscle, and their interaction. Despite a lack of sex-differences in peak discharge rates across all muscles, estimates of PICs were larger [χ2(1) = 6.26, P = 0.012] in females [4.73 ± 0.242 pulses per second (pps)] than in males (3.81 ± 0.240 pps). These findings suggest that neuromodulatory drive, inhibitory input, and/or biophysical properties of motoneurons differ between the sexes and may contribute to differences in MU discharge patterns.NEW & NOTEWORTHY Sex-related differences in motoneuron analyses have emerged with greater inclusion of female participants, however, mechanisms for these differences remain unclear. Estimates of persistent inward currents (i.e., ΔF) in motoneurons of the lower limb muscles were larger in females than in males. This suggests neuromodulatory drive, monoaminergic signaling, intrinsic motoneuron properties, and/or descending motor commands may differ between the sexes, which provides a potential mechanism underlying previously reported sex-related differences in motoneuron discharge patterns." @default.
• W4366985722 created "2023-04-27" @default.
• W4366985722 creator A5032001702 @default.
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• W4366985722 creator A5054373445 @default.
• W4366985722 creator A5060289341 @default.
• W4366985722 creator A5075070871 @default.
• W4366985722 date "2023-06-01" @default.
• W4366985722 modified "2023-10-18" @default.
• W4366985722 title "Estimates of persistent inward currents in lower limb motoneurons are larger in females than in males" @default.
• W4366985722 cites W1032545587 @default.
• W4366985722 cites W1484602144 @default.
• W4366985722 cites W1539272885 @default.
• W4366985722 cites W1608846710 @default.
• W4366985722 cites W1901324775 @default.
• W4366985722 cites W1951724000 @default.
• W4366985722 cites W1965942749 @default.
• W4366985722 cites W1985033275 @default.
• W4366985722 cites W1986878360 @default.
• W4366985722 cites W1999967173 @default.
• W4366985722 cites W2009792683 @default.
• W4366985722 cites W2013290704 @default.
• W4366985722 cites W2015870700 @default.
• W4366985722 cites W2020228453 @default.
• W4366985722 cites W2029098037 @default.
• W4366985722 cites W2029359502 @default.
• W4366985722 cites W2034093770 @default.
• W4366985722 cites W2038918906 @default.
• W4366985722 cites W2044645430 @default.
• W4366985722 cites W2052269256 @default.
• W4366985722 cites W2062787115 @default.
• W4366985722 cites W2063049602 @default.
• W4366985722 cites W2067994158 @default.
• W4366985722 cites W2071287617 @default.
• W4366985722 cites W2074644663 @default.
• W4366985722 cites W2086719258 @default.
• W4366985722 cites W2094109313 @default.
• W4366985722 cites W2098118593 @default.
• W4366985722 cites W2114111541 @default.
• W4366985722 cites W2122371015 @default.
• W4366985722 cites W2149842394 @default.
• W4366985722 cites W2154554143 @default.
• W4366985722 cites W2155307791 @default.
• W4366985722 cites W2156969997 @default.
• W4366985722 cites W2159687614 @default.
• W4366985722 cites W2162147892 @default.
• W4366985722 cites W2162772948 @default.
• W4366985722 cites W2166196669 @default.
• W4366985722 cites W2170242519 @default.
• W4366985722 cites W2209403298 @default.
• W4366985722 cites W2274142243 @default.
• W4366985722 cites W2290981976 @default.
• W4366985722 cites W2338921649 @default.
• W4366985722 cites W2403560496 @default.
• W4366985722 cites W2549621444 @default.
• W4366985722 cites W2602300977 @default.
• W4366985722 cites W2774486220 @default.
• W4366985722 cites W2786233526 @default.
• W4366985722 cites W2887020095 @default.
• W4366985722 cites W2900168537 @default.
• W4366985722 cites W2922194850 @default.
• W4366985722 cites W2935992304 @default.
• W4366985722 cites W2966752812 @default.
• W4366985722 cites W2992552706 @default.
• W4366985722 cites W2993424755 @default.
• W4366985722 cites W3013140416 @default.
• W4366985722 cites W3020122634 @default.
• W4366985722 cites W3021157419 @default.
• W4366985722 cites W3029155313 @default.
• W4366985722 cites W3033989122 @default.
• W4366985722 cites W3038129200 @default.
• W4366985722 cites W3042485542 @default.
• W4366985722 cites W3081596726 @default.
• W4366985722 cites W3083745310 @default.
• W4366985722 cites W3119942504 @default.
• W4366985722 cites W3131409159 @default.
• W4366985722 cites W3134621199 @default.
• W4366985722 cites W3139945342 @default.
• W4366985722 cites W3151646501 @default.
• W4366985722 cites W3197108340 @default.
• W4366985722 cites W4200526320 @default.
• W4366985722 cites W4211072146 @default.
• W4366985722 cites W4213277605 @default.
• W4366985722 cites W4223979649 @default.
• W4366985722 cites W4280511430 @default.
• W4366985722 cites W4283320320 @default.
• W4366985722 cites W4285605255 @default.
• W4366985722 cites W4286718023 @default.
• W4366985722 cites W4289779282 @default.
• W4366985722 cites W4294770058 @default.
• W4366985722 cites W4295438405 @default.
• W4366985722 cites W4304974787 @default.
• W4366985722 cites W4307250418 @default.
• W4366985722 cites W4315432772 @default.
• W4366985722 cites W79973729 @default.
• W4366985722 doi "https://doi.org/10.1152/jn.00043.2023" @default.
• W4366985722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37096909" @default.

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