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- W4366986618 abstract "Outcomes are excellent for the majority of patients with Wilms tumors (WT). However, there remain WT subgroups for which the survival rate is approximately 50% or lower. Acknowledging that the composition of this high-risk group has changed over time reflecting improvements in therapy, we introduce the authors' view of the historical and current approach to the classification and treatment of high-risk WT. For this review, we consider high-risk WT to include patients with newly diagnosed metastatic blastemal-type or diffuse anaplastic histology, those who relapse after having been initially treated with three or more different chemotherapeutics, or those who relapse more than once. In certain low- or low middle-income settings, socio-economic factors expand the definition of what constitutes a high-risk WT. As conventional therapies are inadequate to cure the majority of high-risk WT patients, advancement of laboratory and early-phase clinical investigations to identify active agents is urgently needed." @default.
- W4366986618 created "2023-04-27" @default.
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- W4366986618 date "2023-04-25" @default.
- W4366986618 modified "2023-09-30" @default.
- W4366986618 title "Advances in the clinical management of high‐risk Wilms tumors" @default.
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- W4366986618 doi "https://doi.org/10.1002/pbc.30342" @default.
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