Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366987164> ?p ?o ?g. }
- W4366987164 endingPage "2454" @default.
- W4366987164 startingPage "2454" @default.
- W4366987164 abstract "Cholangiocarcinoma (CCA) is a heterogenous malignancy that arises from the biliary epithelium and has a poor clinical prognosis. The Hippo/yes-associated protein (YAP) pathway has been reported to affect various aspects of tumorigenesis, with high expression of YAP1 being negatively associated with survival in CCA patients. Thus, we investigated the antitumoral effect of verteporfin, a YAP1 pathway inhibitor, in YAP1/AKT hydrodynamic tail vein injected murine models. We also used flow cytometry and single-cell RNA sequencing (scRNA-seq) to analyze the change in the immune cell profile and malignant cell stemness following verteporfin treatment. Our results demonstrated reduced liver weight and tumor formation in verteporfin-treated groups compared to that of a vehicle-treated group. Immune cell profiling through flow cytometry showed that relative to the vehicle, verteporfin induced a higher ratio of tumor-associated macrophage (TAM) M1/M2 and increased the percentage of activated CD8 T cell population (CD8+CD25+ and CD8+CD69+). scRNA-seq analysis showed significantly increased TAM M1 populations following verteporfin treatment and decreased proportions of stem-like cells within the malignant cell population. In summary, this study indicates that in CCA YAP/AKT murine models, verteporfin reduces tumorigenesis by polarizing anti-tumoral TAM and activating CD8 T cells and decreasing stem-like malignant cell proportions in the tumor microenvironment." @default.
- W4366987164 created "2023-04-27" @default.
- W4366987164 creator A5006711829 @default.
- W4366987164 creator A5010437305 @default.
- W4366987164 creator A5019498980 @default.
- W4366987164 creator A5025086832 @default.
- W4366987164 creator A5028107453 @default.
- W4366987164 creator A5038927917 @default.
- W4366987164 creator A5069446152 @default.
- W4366987164 creator A5078103351 @default.
- W4366987164 date "2023-04-25" @default.
- W4366987164 modified "2023-09-27" @default.
- W4366987164 title "Anti-Cancer Activity of Verteporfin in Cholangiocarcinoma" @default.
- W4366987164 cites W1916446105 @default.
- W4366987164 cites W1963570372 @default.
- W4366987164 cites W2007190645 @default.
- W4366987164 cites W2030017878 @default.
- W4366987164 cites W2031166604 @default.
- W4366987164 cites W2069089843 @default.
- W4366987164 cites W2095785781 @default.
- W4366987164 cites W2100641053 @default.
- W4366987164 cites W2115261608 @default.
- W4366987164 cites W2616155686 @default.
- W4366987164 cites W2760562495 @default.
- W4366987164 cites W2782685575 @default.
- W4366987164 cites W2902652978 @default.
- W4366987164 cites W2910397725 @default.
- W4366987164 cites W2950071764 @default.
- W4366987164 cites W3002407185 @default.
- W4366987164 cites W3010944770 @default.
- W4366987164 cites W3024247862 @default.
- W4366987164 cites W3027286012 @default.
- W4366987164 cites W3033473768 @default.
- W4366987164 cites W3049476680 @default.
- W4366987164 cites W3138538177 @default.
- W4366987164 cites W3144916167 @default.
- W4366987164 cites W3179304282 @default.
- W4366987164 cites W3198098339 @default.
- W4366987164 cites W3207977101 @default.
- W4366987164 cites W344510317 @default.
- W4366987164 cites W4200591611 @default.
- W4366987164 cites W4200618391 @default.
- W4366987164 cites W4220751567 @default.
- W4366987164 cites W4225883630 @default.
- W4366987164 cites W4280515630 @default.
- W4366987164 cites W4281630496 @default.
- W4366987164 cites W4317355154 @default.
- W4366987164 doi "https://doi.org/10.3390/cancers15092454" @default.
- W4366987164 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37173920" @default.
- W4366987164 hasPublicationYear "2023" @default.
- W4366987164 type Work @default.
- W4366987164 citedByCount "0" @default.
- W4366987164 crossrefType "journal-article" @default.
- W4366987164 hasAuthorship W4366987164A5006711829 @default.
- W4366987164 hasAuthorship W4366987164A5010437305 @default.
- W4366987164 hasAuthorship W4366987164A5019498980 @default.
- W4366987164 hasAuthorship W4366987164A5025086832 @default.
- W4366987164 hasAuthorship W4366987164A5028107453 @default.
- W4366987164 hasAuthorship W4366987164A5038927917 @default.
- W4366987164 hasAuthorship W4366987164A5069446152 @default.
- W4366987164 hasAuthorship W4366987164A5078103351 @default.
- W4366987164 hasBestOaLocation W43669871641 @default.
- W4366987164 hasConcept C118487528 @default.
- W4366987164 hasConcept C121608353 @default.
- W4366987164 hasConcept C126322002 @default.
- W4366987164 hasConcept C1491633281 @default.
- W4366987164 hasConcept C167672396 @default.
- W4366987164 hasConcept C185592680 @default.
- W4366987164 hasConcept C203014093 @default.
- W4366987164 hasConcept C2776107976 @default.
- W4366987164 hasConcept C2776403814 @default.
- W4366987164 hasConcept C2781148688 @default.
- W4366987164 hasConcept C2781359195 @default.
- W4366987164 hasConcept C2908647359 @default.
- W4366987164 hasConcept C502942594 @default.
- W4366987164 hasConcept C553184892 @default.
- W4366987164 hasConcept C55493867 @default.
- W4366987164 hasConcept C555283112 @default.
- W4366987164 hasConcept C71924100 @default.
- W4366987164 hasConcept C86803240 @default.
- W4366987164 hasConcept C8891405 @default.
- W4366987164 hasConcept C99454951 @default.
- W4366987164 hasConceptScore W4366987164C118487528 @default.
- W4366987164 hasConceptScore W4366987164C121608353 @default.
- W4366987164 hasConceptScore W4366987164C126322002 @default.
- W4366987164 hasConceptScore W4366987164C1491633281 @default.
- W4366987164 hasConceptScore W4366987164C167672396 @default.
- W4366987164 hasConceptScore W4366987164C185592680 @default.
- W4366987164 hasConceptScore W4366987164C203014093 @default.
- W4366987164 hasConceptScore W4366987164C2776107976 @default.
- W4366987164 hasConceptScore W4366987164C2776403814 @default.
- W4366987164 hasConceptScore W4366987164C2781148688 @default.
- W4366987164 hasConceptScore W4366987164C2781359195 @default.
- W4366987164 hasConceptScore W4366987164C2908647359 @default.
- W4366987164 hasConceptScore W4366987164C502942594 @default.
- W4366987164 hasConceptScore W4366987164C553184892 @default.
- W4366987164 hasConceptScore W4366987164C55493867 @default.
- W4366987164 hasConceptScore W4366987164C555283112 @default.