Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366987489> ?p ?o ?g. }
- W4366987489 endingPage "7801" @default.
- W4366987489 startingPage "7801" @default.
- W4366987489 abstract "The aryl hydrocarbon receptor (AhR) is a decisive regulatory ligand-dependent transcription factor. It binds highly diverse ligands, which can be categorized as either endogenous or exogenous. Ligand binding activates AhR, which can adjust inflammatory responses by modulating immune cells such as dendritic cells (DCs). However, how different AhR ligand classes impact the phenotype and function of human monocyte-derived DCs (hMoDCs) has not been extensively studied in a comparative manner. We, therefore, tested the effect of the representative compounds Benzo(a)pyrene (BP), 6-formylindolo[3,2-b]carbazole (FICZ), and Indoxyl 3-sulfate (I3S) on DC biology. Thereby, we reveal that BP significantly induces a tolerogenic response in lipopolysaccharide-matured DCs, which is not apparent to the same extent when using FICZ or I3S. While all three ligand classes activate AhR-dependent pathways, BP especially induces the expression of negative immune regulators, and subsequently strongly subverts the T cell stimulatory capacity of DCs. Using the CRISPR/Cas9 strategy we also prove that the regulatory effect of BP is strictly AhR-dependent. These findings imply that AhR ligands contribute differently to DC responses and incite further studies to uncover the mechanisms and molecules which are involved in the induction of different phenotypes and functions in DCs upon AhR activation." @default.
- W4366987489 created "2023-04-27" @default.
- W4366987489 creator A5014101378 @default.
- W4366987489 creator A5015255309 @default.
- W4366987489 creator A5024294609 @default.
- W4366987489 creator A5034389433 @default.
- W4366987489 creator A5038474211 @default.
- W4366987489 creator A5063808741 @default.
- W4366987489 creator A5071263010 @default.
- W4366987489 creator A5079046795 @default.
- W4366987489 date "2023-04-25" @default.
- W4366987489 modified "2023-10-14" @default.
- W4366987489 title "Differential Modulation of Dendritic Cell Biology by Endogenous and Exogenous Aryl Hydrocarbon Receptor Ligands" @default.
- W4366987489 cites W1577296862 @default.
- W4366987489 cites W1595832213 @default.
- W4366987489 cites W1607733107 @default.
- W4366987489 cites W1967415740 @default.
- W4366987489 cites W1971187113 @default.
- W4366987489 cites W1978870153 @default.
- W4366987489 cites W1989015119 @default.
- W4366987489 cites W1989044153 @default.
- W4366987489 cites W1993003564 @default.
- W4366987489 cites W1997322438 @default.
- W4366987489 cites W1998993174 @default.
- W4366987489 cites W2004522121 @default.
- W4366987489 cites W2008343182 @default.
- W4366987489 cites W2011427930 @default.
- W4366987489 cites W2022022565 @default.
- W4366987489 cites W2048341194 @default.
- W4366987489 cites W2052944102 @default.
- W4366987489 cites W2064813777 @default.
- W4366987489 cites W2074982340 @default.
- W4366987489 cites W2098921988 @default.
- W4366987489 cites W2103273228 @default.
- W4366987489 cites W2108953680 @default.
- W4366987489 cites W2110651507 @default.
- W4366987489 cites W2120473115 @default.
- W4366987489 cites W2138005968 @default.
- W4366987489 cites W2144611363 @default.
- W4366987489 cites W2146884288 @default.
- W4366987489 cites W2150992270 @default.
- W4366987489 cites W2155897723 @default.
- W4366987489 cites W2164069187 @default.
- W4366987489 cites W2168420558 @default.
- W4366987489 cites W2170240282 @default.
- W4366987489 cites W2396424530 @default.
- W4366987489 cites W2399548900 @default.
- W4366987489 cites W2533570264 @default.
- W4366987489 cites W2593772227 @default.
- W4366987489 cites W2605198180 @default.
- W4366987489 cites W2606250554 @default.
- W4366987489 cites W2741487737 @default.
- W4366987489 cites W2762602063 @default.
- W4366987489 cites W2782774905 @default.
- W4366987489 cites W2891360658 @default.
- W4366987489 cites W2899789156 @default.
- W4366987489 cites W2900194457 @default.
- W4366987489 cites W2901810832 @default.
- W4366987489 cites W2911968308 @default.
- W4366987489 cites W2973273720 @default.
- W4366987489 cites W2994354506 @default.
- W4366987489 cites W3008023092 @default.
- W4366987489 cites W3086418814 @default.
- W4366987489 cites W3129598503 @default.
- W4366987489 cites W3199908805 @default.
- W4366987489 cites W4243627407 @default.
- W4366987489 cites W2899964425 @default.
- W4366987489 doi "https://doi.org/10.3390/ijms24097801" @default.
- W4366987489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37175508" @default.
- W4366987489 hasPublicationYear "2023" @default.
- W4366987489 type Work @default.
- W4366987489 citedByCount "0" @default.
- W4366987489 crossrefType "journal-article" @default.
- W4366987489 hasAuthorship W4366987489A5014101378 @default.
- W4366987489 hasAuthorship W4366987489A5015255309 @default.
- W4366987489 hasAuthorship W4366987489A5024294609 @default.
- W4366987489 hasAuthorship W4366987489A5034389433 @default.
- W4366987489 hasAuthorship W4366987489A5038474211 @default.
- W4366987489 hasAuthorship W4366987489A5063808741 @default.
- W4366987489 hasAuthorship W4366987489A5071263010 @default.
- W4366987489 hasAuthorship W4366987489A5079046795 @default.
- W4366987489 hasBestOaLocation W43669874891 @default.
- W4366987489 hasConcept C104317684 @default.
- W4366987489 hasConcept C116569031 @default.
- W4366987489 hasConcept C16613235 @default.
- W4366987489 hasConcept C170493617 @default.
- W4366987489 hasConcept C185592680 @default.
- W4366987489 hasConcept C203014093 @default.
- W4366987489 hasConcept C2778170410 @default.
- W4366987489 hasConcept C33594762 @default.
- W4366987489 hasConcept C55493867 @default.
- W4366987489 hasConcept C62478195 @default.
- W4366987489 hasConcept C86339819 @default.
- W4366987489 hasConcept C86803240 @default.
- W4366987489 hasConcept C8891405 @default.
- W4366987489 hasConcept C95444343 @default.
- W4366987489 hasConceptScore W4366987489C104317684 @default.
- W4366987489 hasConceptScore W4366987489C116569031 @default.