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- W4366988433 abstract "Post-traumatic stress disorder (PTSD) is a chronic incapacitating condition with recurrent experience of trauma-related memories, negative mood, altered cognition, and hypervigilance. Agglomeration of preclinical and clinical evidence in recent years specified that alterations in neural networks favor certain characteristics of PTSD. Besides the disruption of hypothalamus-pituitary-axis (HPA) axis, intensified immune status with elevated pro-inflammatory cytokines and arachidonic metabolites of COX-2 such as PGE2 creates a putative scenario in worsening the neurobehavioral facet of PTSD. This review aims to link the Diagnostic and Statistical Manual of mental disorders (DSM-V) symptomology to major neural mechanisms that are supposed to underpin the transition from acute stress reactions to the development of PTSD. Also, to demonstrate how these intertwined processes can be applied to probable early intervention strategies followed by a description of the evidence supporting the proposed mechanisms. Hence in this review, several neural network mechanisms were postulated concerning the HPA axis, COX-2, PGE2, NLRP3, and sirtuins to unravel possible complex neuroinflammatory mechanisms that are obscured in PTSD condition." @default.
- W4366988433 created "2023-04-27" @default.
- W4366988433 creator A5027481746 @default.
- W4366988433 creator A5039271873 @default.
- W4366988433 creator A5046306454 @default.
- W4366988433 creator A5068190843 @default.
- W4366988433 creator A5082985881 @default.
- W4366988433 creator A5083331688 @default.
- W4366988433 date "2023-04-25" @default.
- W4366988433 modified "2023-10-18" @default.
- W4366988433 title "Emphasizing the Crosstalk Between Inflammatory and Neural Signaling in Post-traumatic Stress Disorder (PTSD)" @default.
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