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• W4366988904 endingPage "2440" @default.
• W4366988904 startingPage "2440" @default.
• W4366988904 abstract "White adipose tissue (WAT) represents an endocrinologically and immunologically active tissue whose primary role is energy storage and homeostasis. Breast WAT is involved in the secretion of hormones and proinflammatory molecules that are associated with breast cancer development and progression. The role of adiposity and systemic inflammation in immune responses and resistance to anti-cancer treatment in breast cancer (BC) patients is still not clear. Metformin has demonstrated antitumorigenic properties both in pre-clinical and clinical studies. Nevertheless, its immunomodulating properties in BC are largely unknown. This review aims to evaluate the emerging evidence on the crosstalk between adiposity and the immune-tumour microenvironment in BC, its progression and treatment resistance, and the immunometabolic role of metformin in BC. Adiposity, and by extension subclinical inflammation, are associated with metabolic dysfunction and changes in the immune-tumour microenvironment in BC. In oestrogen receptor positive (ER+) breast tumours, it is proposed that these changes are mediated via a paracrine interaction between macrophages and preadipocytes, leading to elevated aromatase expression and secretion of pro-inflammatory cytokines and adipokines in the breast tissue in patients who are obese or overweight. In HER2+ breast tumours, WAT inflammation has been shown to be associated with resistance to trastuzumab mediated via MAPK or PI3K pathways. Furthermore, adipose tissue in patients with obesity is associated with upregulation of immune checkpoints on T-cells that is partially mediated via immunomodulatory effects of leptin and has been paradoxically associated with improved responses to immunotherapy in several cancers. Metformin may play a role in the metabolic reprogramming of tumour-infiltrating immune cells that are dysregulated by systemic inflammation. In conclusion, evidence suggests that body composition and metabolic status are associated with patient outcomes. To optimise patient stratification and personalisation of treatment, prospective studies are required to evaluate the role of body composition and metabolic parameters in metabolic immune reprogramming with and without immunotherapy in patients with BC." @default.
• W4366988904 created "2023-04-27" @default.
• W4366988904 creator A5007119947 @default.
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• W4366988904 creator A5073058385 @default.
• W4366988904 date "2023-04-24" @default.
• W4366988904 modified "2023-09-26" @default.
• W4366988904 title "Obesity Is Associated with Immunometabolic Changes in Adipose Tissue That May Drive Treatment Resistance in Breast Cancer: Immune-Metabolic Reprogramming and Novel Therapeutic Strategies" @default.
• W4366988904 cites W1901407464 @default.
• W4366988904 cites W1910532636 @default.
• W4366988904 cites W1964796703 @default.
• W4366988904 cites W1966037324 @default.
• W4366988904 cites W1968144622 @default.
• W4366988904 cites W1973185447 @default.
• W4366988904 cites W1973668609 @default.
• W4366988904 cites W1979580921 @default.
• W4366988904 cites W1991309264 @default.
• W4366988904 cites W2000637574 @default.
• W4366988904 cites W2007518082 @default.
• W4366988904 cites W2019335338 @default.
• W4366988904 cites W2026161601 @default.
• W4366988904 cites W2028156437 @default.
• W4366988904 cites W2034825007 @default.
• W4366988904 cites W2040207652 @default.
• W4366988904 cites W2042259492 @default.
• W4366988904 cites W2044702943 @default.
• W4366988904 cites W2055970529 @default.
• W4366988904 cites W2078145223 @default.
• W4366988904 cites W2089658873 @default.
• W4366988904 cites W2090556647 @default.
• W4366988904 cites W2091725413 @default.
• W4366988904 cites W2096283457 @default.
• W4366988904 cites W2102809213 @default.
• W4366988904 cites W2108833696 @default.
• W4366988904 cites W2110603890 @default.
• W4366988904 cites W2110630581 @default.
• W4366988904 cites W2115585914 @default.
• W4366988904 cites W2119036906 @default.
• W4366988904 cites W2126733181 @default.
• W4366988904 cites W2128402413 @default.
• W4366988904 cites W2136731993 @default.
• W4366988904 cites W2139716106 @default.
• W4366988904 cites W2141189887 @default.
• W4366988904 cites W2143055774 @default.
• W4366988904 cites W2145697808 @default.
• W4366988904 cites W2149466392 @default.
• W4366988904 cites W2156280702 @default.
• W4366988904 cites W2163710303 @default.
• W4366988904 cites W2164408432 @default.
• W4366988904 cites W2165334726 @default.
• W4366988904 cites W2216971459 @default.
• W4366988904 cites W2342466558 @default.
• W4366988904 cites W2346108121 @default.
• W4366988904 cites W2388453346 @default.
• W4366988904 cites W2401695046 @default.
• W4366988904 cites W2414790256 @default.
• W4366988904 cites W2496209031 @default.
• W4366988904 cites W2521615826 @default.
• W4366988904 cites W2524637936 @default.
• W4366988904 cites W2528328462 @default.
• W4366988904 cites W2560185130 @default.
• W4366988904 cites W2560367415 @default.
• W4366988904 cites W2576506095 @default.
• W4366988904 cites W2592267552 @default.
• W4366988904 cites W2606711458 @default.
• W4366988904 cites W2609897316 @default.
• W4366988904 cites W2611395550 @default.
• W4366988904 cites W2612189159 @default.
• W4366988904 cites W2745210831 @default.
• W4366988904 cites W2749524176 @default.
• W4366988904 cites W2753432434 @default.
• W4366988904 cites W2755846058 @default.
• W4366988904 cites W2767159687 @default.
• W4366988904 cites W2769509722 @default.
• W4366988904 cites W2771455181 @default.
• W4366988904 cites W2775399716 @default.
• W4366988904 cites W2783329544 @default.
• W4366988904 cites W2786396800 @default.
• W4366988904 cites W2790745850 @default.
• W4366988904 cites W2793286226 @default.
• W4366988904 cites W2793982601 @default.
• W4366988904 cites W2797521429 @default.
• W4366988904 cites W2800324021 @default.
• W4366988904 cites W2801335865 @default.
• W4366988904 cites W2804480996 @default.
• W4366988904 cites W2809965878 @default.
• W4366988904 cites W2885288866 @default.
• W4366988904 cites W2891855400 @default.
• W4366988904 cites W2891983638 @default.
• W4366988904 cites W2897422388 @default.
• W4366988904 cites W2898691643 @default.
• W4366988904 cites W2898946138 @default.
• W4366988904 cites W2899024107 @default.
• W4366988904 cites W2900135008 @default.
• W4366988904 cites W2900496024 @default.
• W4366988904 cites W2905543221 @default.

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