Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366988989> ?p ?o ?g. }
- W4366988989 endingPage "7772" @default.
- W4366988989 startingPage "7772" @default.
- W4366988989 abstract "By virtue of mitochondrial control of energy production, reactive oxygen species (ROS) generation, and maintenance of Ca2+ homeostasis, mitochondria play an essential role in modulating T cell function. The mitochondrial Ca2+ uniporter (MCU) is the pore-forming unit in the main protein complex mediating mitochondrial Ca2+ uptake. Recently, MCU has been shown to modulate Ca2+ signals at subcellular organellar interfaces, thus fine-tuning NFAT translocation and T cell activation. The mechanisms underlying this modulation and whether MCU has additional T cell subpopulation-specific effects remain elusive. However, mice with germline or tissue-specific ablation of Mcu did not show impaired T cell responses in vitro or in vivo, indicating that 'chronic' loss of MCU can be functionally compensated in lymphocytes. The current work aimed to specifically investigate whether and how MCU influences the suppressive potential of regulatory CD4 T cells (Treg). We show that, in contrast to genetic ablation, acute siRNA-mediated downregulation of Mcu in murine Tregs results in a significant reduction both in mitochondrial Ca2+ uptake and in the suppressive capacity of Tregs, while the ratios of Treg subpopulations and the expression of hallmark transcription factors were not affected. These findings suggest that permanent genetic inactivation of MCU may result in compensatory adaptive mechanisms, masking the effects on the suppressive capacity of Tregs." @default.
- W4366988989 created "2023-04-27" @default.
- W4366988989 creator A5018232279 @default.
- W4366988989 creator A5019680177 @default.
- W4366988989 creator A5029832458 @default.
- W4366988989 creator A5047796112 @default.
- W4366988989 creator A5052372489 @default.
- W4366988989 creator A5063614514 @default.
- W4366988989 creator A5063907700 @default.
- W4366988989 creator A5075875108 @default.
- W4366988989 creator A5084477559 @default.
- W4366988989 creator A5086907498 @default.
- W4366988989 date "2023-04-24" @default.
- W4366988989 modified "2023-09-27" @default.
- W4366988989 title "Acute Downregulation but Not Genetic Ablation of Murine MCU Impairs Suppressive Capacity of Regulatory CD4 T Cells" @default.
- W4366988989 cites W1486227004 @default.
- W4366988989 cites W1523821352 @default.
- W4366988989 cites W1669573844 @default.
- W4366988989 cites W1986457087 @default.
- W4366988989 cites W1998639983 @default.
- W4366988989 cites W2004273407 @default.
- W4366988989 cites W2010315866 @default.
- W4366988989 cites W2019961716 @default.
- W4366988989 cites W2020293242 @default.
- W4366988989 cites W2034781878 @default.
- W4366988989 cites W2038549341 @default.
- W4366988989 cites W2081369737 @default.
- W4366988989 cites W2085013996 @default.
- W4366988989 cites W2111094496 @default.
- W4366988989 cites W2130454564 @default.
- W4366988989 cites W2139052757 @default.
- W4366988989 cites W2141146025 @default.
- W4366988989 cites W2160790532 @default.
- W4366988989 cites W2164156889 @default.
- W4366988989 cites W2735720719 @default.
- W4366988989 cites W2755712391 @default.
- W4366988989 cites W2761356900 @default.
- W4366988989 cites W2768338741 @default.
- W4366988989 cites W2781926206 @default.
- W4366988989 cites W2790726687 @default.
- W4366988989 cites W2791358733 @default.
- W4366988989 cites W2795853679 @default.
- W4366988989 cites W2803650666 @default.
- W4366988989 cites W2888917034 @default.
- W4366988989 cites W2900171124 @default.
- W4366988989 cites W2905643675 @default.
- W4366988989 cites W2909014200 @default.
- W4366988989 cites W3000598146 @default.
- W4366988989 cites W3033593083 @default.
- W4366988989 cites W3044549502 @default.
- W4366988989 cites W3046342042 @default.
- W4366988989 cites W3092481167 @default.
- W4366988989 cites W3110465495 @default.
- W4366988989 cites W3136878417 @default.
- W4366988989 cites W3198444904 @default.
- W4366988989 cites W3210932179 @default.
- W4366988989 cites W4200139596 @default.
- W4366988989 cites W813983228 @default.
- W4366988989 doi "https://doi.org/10.3390/ijms24097772" @default.
- W4366988989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37175478" @default.
- W4366988989 hasPublicationYear "2023" @default.
- W4366988989 type Work @default.
- W4366988989 citedByCount "0" @default.
- W4366988989 crossrefType "journal-article" @default.
- W4366988989 hasAuthorship W4366988989A5018232279 @default.
- W4366988989 hasAuthorship W4366988989A5019680177 @default.
- W4366988989 hasAuthorship W4366988989A5029832458 @default.
- W4366988989 hasAuthorship W4366988989A5047796112 @default.
- W4366988989 hasAuthorship W4366988989A5052372489 @default.
- W4366988989 hasAuthorship W4366988989A5063614514 @default.
- W4366988989 hasAuthorship W4366988989A5063907700 @default.
- W4366988989 hasAuthorship W4366988989A5075875108 @default.
- W4366988989 hasAuthorship W4366988989A5084477559 @default.
- W4366988989 hasAuthorship W4366988989A5086907498 @default.
- W4366988989 hasBestOaLocation W43669889891 @default.
- W4366988989 hasConcept C104317684 @default.
- W4366988989 hasConcept C127561419 @default.
- W4366988989 hasConcept C203014093 @default.
- W4366988989 hasConcept C2776090121 @default.
- W4366988989 hasConcept C28859421 @default.
- W4366988989 hasConcept C55493867 @default.
- W4366988989 hasConcept C86339819 @default.
- W4366988989 hasConcept C86803240 @default.
- W4366988989 hasConcept C8891405 @default.
- W4366988989 hasConcept C95444343 @default.
- W4366988989 hasConceptScore W4366988989C104317684 @default.
- W4366988989 hasConceptScore W4366988989C127561419 @default.
- W4366988989 hasConceptScore W4366988989C203014093 @default.
- W4366988989 hasConceptScore W4366988989C2776090121 @default.
- W4366988989 hasConceptScore W4366988989C28859421 @default.
- W4366988989 hasConceptScore W4366988989C55493867 @default.
- W4366988989 hasConceptScore W4366988989C86339819 @default.
- W4366988989 hasConceptScore W4366988989C86803240 @default.
- W4366988989 hasConceptScore W4366988989C8891405 @default.
- W4366988989 hasConceptScore W4366988989C95444343 @default.
- W4366988989 hasIssue "9" @default.
- W4366988989 hasLocation W43669889891 @default.
- W4366988989 hasLocation W43669889892 @default.