Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366989230> ?p ?o ?g. }
- W4366989230 abstract "The tumor necrosis factor superfamily (TNFSF) and their receptors (TNFRSF) are important regulators of the immune system, mediating proliferation, survival, differentiation, and function of immune cells. As a result, their targeting for immunotherapy is attractive, although to date, under-exploited. In this review we discuss the importance of co-stimulatory members of the TNFRSF in optimal immune response generation, the rationale behind targeting these receptors for immunotherapy, the success of targeting them in pre-clinical studies and the challenges in translating this success into the clinic. The efficacy and limitations of the currently available agents are discussed alongside the development of next generation immunostimulatory agents designed to overcome current issues, and capitalize on this receptor class to deliver potent, durable and safe drugs for patients." @default.
- W4366989230 created "2023-04-27" @default.
- W4366989230 creator A5027887577 @default.
- W4366989230 creator A5050648940 @default.
- W4366989230 creator A5076688601 @default.
- W4366989230 date "2023-04-25" @default.
- W4366989230 modified "2023-10-02" @default.
- W4366989230 title "Delivering co-stimulatory tumor necrosis factor receptor agonism for cancer immunotherapy: past, current and future perspectives" @default.
- W4366989230 cites W1259765513 @default.
- W4366989230 cites W1484684540 @default.
- W4366989230 cites W1487003048 @default.
- W4366989230 cites W1499206957 @default.
- W4366989230 cites W1505996251 @default.
- W4366989230 cites W1521437722 @default.
- W4366989230 cites W1572596428 @default.
- W4366989230 cites W1590618281 @default.
- W4366989230 cites W1601495799 @default.
- W4366989230 cites W1605178114 @default.
- W4366989230 cites W1632142035 @default.
- W4366989230 cites W1717565124 @default.
- W4366989230 cites W1793898094 @default.
- W4366989230 cites W1871780345 @default.
- W4366989230 cites W1890031012 @default.
- W4366989230 cites W1939244106 @default.
- W4366989230 cites W1968117332 @default.
- W4366989230 cites W1968783338 @default.
- W4366989230 cites W1976549140 @default.
- W4366989230 cites W1985508003 @default.
- W4366989230 cites W1985720487 @default.
- W4366989230 cites W1985960971 @default.
- W4366989230 cites W1988280075 @default.
- W4366989230 cites W1993468695 @default.
- W4366989230 cites W1994688157 @default.
- W4366989230 cites W2004290717 @default.
- W4366989230 cites W2016304443 @default.
- W4366989230 cites W2017873446 @default.
- W4366989230 cites W2023776610 @default.
- W4366989230 cites W2027979845 @default.
- W4366989230 cites W2028309691 @default.
- W4366989230 cites W2033746426 @default.
- W4366989230 cites W2040967116 @default.
- W4366989230 cites W2046059844 @default.
- W4366989230 cites W2046382304 @default.
- W4366989230 cites W2046421045 @default.
- W4366989230 cites W2047526240 @default.
- W4366989230 cites W2051305116 @default.
- W4366989230 cites W2053313205 @default.
- W4366989230 cites W2055056105 @default.
- W4366989230 cites W2057745345 @default.
- W4366989230 cites W2058089640 @default.
- W4366989230 cites W2061548387 @default.
- W4366989230 cites W2062755237 @default.
- W4366989230 cites W2071875829 @default.
- W4366989230 cites W2077610119 @default.
- W4366989230 cites W2081476753 @default.
- W4366989230 cites W2086255604 @default.
- W4366989230 cites W2087843772 @default.
- W4366989230 cites W2095013915 @default.
- W4366989230 cites W2100696012 @default.
- W4366989230 cites W2102466154 @default.
- W4366989230 cites W2104088439 @default.
- W4366989230 cites W2105191357 @default.
- W4366989230 cites W2106134589 @default.
- W4366989230 cites W2109496987 @default.
- W4366989230 cites W2110377793 @default.
- W4366989230 cites W2112123471 @default.
- W4366989230 cites W2117776341 @default.
- W4366989230 cites W2119008186 @default.
- W4366989230 cites W2119139416 @default.
- W4366989230 cites W2119410505 @default.
- W4366989230 cites W2123161339 @default.
- W4366989230 cites W2126535501 @default.
- W4366989230 cites W2126578631 @default.
- W4366989230 cites W2130819559 @default.
- W4366989230 cites W2131399528 @default.
- W4366989230 cites W2134435470 @default.
- W4366989230 cites W2135305016 @default.
- W4366989230 cites W2137770268 @default.
- W4366989230 cites W2144420689 @default.
- W4366989230 cites W2151410975 @default.
- W4366989230 cites W2152730543 @default.
- W4366989230 cites W2153519961 @default.
- W4366989230 cites W2154126938 @default.
- W4366989230 cites W2154529583 @default.
- W4366989230 cites W2161261138 @default.
- W4366989230 cites W2164581539 @default.
- W4366989230 cites W2165051502 @default.
- W4366989230 cites W2168448733 @default.
- W4366989230 cites W2169772944 @default.
- W4366989230 cites W2229724582 @default.
- W4366989230 cites W2411733041 @default.
- W4366989230 cites W2509587195 @default.
- W4366989230 cites W2524917460 @default.
- W4366989230 cites W2533941196 @default.
- W4366989230 cites W2537734913 @default.
- W4366989230 cites W2549757281 @default.
- W4366989230 cites W2563543508 @default.
- W4366989230 cites W2572869521 @default.
- W4366989230 cites W2576600737 @default.
- W4366989230 cites W2576663873 @default.