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- W4366989404 abstract "Almost all cervical cancers are caused by infection with high-risk human papillomaviruses (HPVs) (1-3); the transcriptional features that distinguish the gene expression programs of HPV-induced cancers from that of cancers resulting from non-viral abrogation of tumor suppression remain incompletely defined. We mined published microarray datasets (4, 5) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with the most common type of cervical cancer, cervical squamous cell carcinoma. We found significant differential expression of the gene encoding minichromosome maintenance complex component 5, MCM5, when comparing tumor tissue from the human cervix to the tissue of origin. MCM5 mRNA was present at significantly higher quantities in tumors of the cervix as compared to normal tissues from the cervix. Analysis of human survival data revealed that expression of MCM5 in tumors of the cervix was correlated with overall survival in patients with cervical cancer. MCM5 expression changes may be important for the initiation or progression of cancer of the cervix in humans." @default.
- W4366989404 created "2023-04-27" @default.
- W4366989404 creator A5024900493 @default.
- W4366989404 date "2023-04-24" @default.
- W4366989404 modified "2023-09-29" @default.
- W4366989404 title "Differential expression of MCM5 in cancer of the cervix." @default.
- W4366989404 doi "https://doi.org/10.31219/osf.io/d629u" @default.
- W4366989404 hasPublicationYear "2023" @default.
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