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- W4366990012 abstract "Almost all cervical cancers are caused by infection with high-risk human papillomaviruses (HPVs) (1-3); the transcriptional features that distinguish the gene expression programs of HPV-induced cancers from that of cancers resulting from non-viral abrogation of tumor suppression remain incompletely defined. We mined published microarray datasets (4, 5) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with the most common type of cervical cancer, cervical squamous cell carcinoma. We found significant differential expression of the gene encoding CDC28 protein kinase regulatory subunit 2, CKS2, when comparing tumor tissue from the human cervix to the tissue of origin. CKS2 mRNA was present at significantly higher quantities in tumors of the cervix as compared to normal tissues from the cervix. Analysis of human survival data revealed that expression of CKS2 in tumors of the cervix was correlated with recurrence-free survival in patients with cervical cancer. CKS2 expression changes may be important for the initiation or progression of cancer of the cervix in humans." @default.
- W4366990012 created "2023-04-27" @default.
- W4366990012 creator A5024900493 @default.
- W4366990012 date "2023-04-24" @default.
- W4366990012 modified "2023-09-29" @default.
- W4366990012 title "Differential expression of CKS2 in cancer of the cervix." @default.
- W4366990012 doi "https://doi.org/10.31219/osf.io/r2m6c" @default.
- W4366990012 hasPublicationYear "2023" @default.
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