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• W4366990120 abstract "STAT3 N-terminal domain is a promising molecular target for cancer treatment and modulation of immune responses. However, STAT3 is localized in the cytoplasm, mitochondria, and nuclei, and thus, is inaccessible to therapeutic antibodies. Its N-terminal domain lacks deep pockets on the surface and represents a typical non-druggable protein. In order to successfully identify potent and selective inhibitors of the domain, we have used virtual screening of billion structure-sized virtual libraries of make-on-demand screening samples. The results suggest that the expansion of accessible chemical space by cutting-edge ultra-large virtual compound databases can lead to successful development of small molecule drugs for hard-to-target intracellular proteins." @default.
• W4366990120 created "2023-04-27" @default.
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• W4366990120 date "2023-04-25" @default.
• W4366990120 modified "2023-09-27" @default.
• W4366990120 title "Virtual screening of ultra-large chemical libraries identifies cell-permeable small-molecule inhibitors of a “non-druggable” target, STAT3 N-terminal domain" @default.
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• W4366990120 doi "https://doi.org/10.3389/fonc.2023.1144153" @default.
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