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- W4366990151 abstract "Almost all cervical cancers are caused by infection with high-risk human papillomaviruses (HPVs) (1-3); the transcriptional features that distinguish the gene expression programs of HPV-induced cancers from that of other solid tumors resulting from non-viral abrogation of tumor suppression remain incompletely defined. We mined published and public microarray datasets (4, 5) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with the most common type of cervical cancer, cervical squamous cell carcinoma. We found significant differential expression of the gene encoding minichromosome maintenance complex component 2, MCM2, when comparing tumor tissue from the human cervix to the tissue of origin. MCM2 mRNA was present at significantly higher quantities in tumors of the cervix as compared to normal tissues from the cervix. Analysis of human survival data revealed that expression of MCM2 in tumors of the cervix was correlated with overall survival in patients with cervical cancer. MCM2 expression changes may be important for the initiation or progression of cancer of the cervix in humans." @default.
- W4366990151 created "2023-04-27" @default.
- W4366990151 creator A5024900493 @default.
- W4366990151 date "2023-04-24" @default.
- W4366990151 modified "2023-09-29" @default.
- W4366990151 title "Differential expression of MCM2 in cancer of the cervix." @default.
- W4366990151 doi "https://doi.org/10.31219/osf.io/2wp3r" @default.
- W4366990151 hasPublicationYear "2023" @default.
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