Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366990438> ?p ?o ?g. }
- W4366990438 endingPage "642" @default.
- W4366990438 startingPage "642" @default.
- W4366990438 abstract "2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid-9,11-dihydro-trifluoroethyl amide (CDDO-dhTFEA) has antioxidant and anti-inflammatory activities; however, whether CDDO-dhTFEA has anticancer effects is unclear. The objective of this research was to investigate the possibility of CDDO-dhTFEA as a potential cancer-fighting treatment in glioblastoma cells. Our experiments were performed on U87MG and GBM8401 cells, and we found that CDDO-dhTFEA was effective in reducing cell proliferation in both cell lines, in a manner that was dependent on both time and concentration. Additionally, we observed that CDDO-dhTFEA had a significant impact on the regulation of cell proliferation, which was evident in the increase in DNA synthesis that was observed in both cell types. CDDO-dhTFEA induced G2/M cell cycle arrest and mitotic delay, which may be associated with the inhibition of proliferation. Treatment with CDDO-dhTFEA led to cell cycle G2/M arrest and inhibited proliferation of U87MG and GBM8401 cells by regulating G2/M cell cycle proteins and gene expression in GBM cells in vitro." @default.
- W4366990438 created "2023-04-27" @default.
- W4366990438 creator A5003155041 @default.
- W4366990438 creator A5009663238 @default.
- W4366990438 creator A5035081089 @default.
- W4366990438 creator A5061797555 @default.
- W4366990438 creator A5064710817 @default.
- W4366990438 creator A5086352198 @default.
- W4366990438 creator A5088317787 @default.
- W4366990438 date "2023-04-24" @default.
- W4366990438 modified "2023-10-16" @default.
- W4366990438 title "A Novel Synthetic Oleanolic Acid Derivative Inhibits Glioma Cell Proliferation by Regulating Cell Cycle G2/M Arrest" @default.
- W4366990438 cites W1955622248 @default.
- W4366990438 cites W1968736625 @default.
- W4366990438 cites W1982861164 @default.
- W4366990438 cites W1992848268 @default.
- W4366990438 cites W1997350836 @default.
- W4366990438 cites W2000178617 @default.
- W4366990438 cites W2004008931 @default.
- W4366990438 cites W2005842596 @default.
- W4366990438 cites W2014613601 @default.
- W4366990438 cites W2015392958 @default.
- W4366990438 cites W2026703836 @default.
- W4366990438 cites W2034015235 @default.
- W4366990438 cites W2035676834 @default.
- W4366990438 cites W2057303356 @default.
- W4366990438 cites W2083394284 @default.
- W4366990438 cites W2086997734 @default.
- W4366990438 cites W2087633043 @default.
- W4366990438 cites W2096287682 @default.
- W4366990438 cites W2099852670 @default.
- W4366990438 cites W2100850228 @default.
- W4366990438 cites W2108408221 @default.
- W4366990438 cites W2114918609 @default.
- W4366990438 cites W2129626942 @default.
- W4366990438 cites W2164675211 @default.
- W4366990438 cites W2188535304 @default.
- W4366990438 cites W2314640825 @default.
- W4366990438 cites W2410841132 @default.
- W4366990438 cites W2769865513 @default.
- W4366990438 cites W2784219914 @default.
- W4366990438 cites W2787398713 @default.
- W4366990438 cites W2950931723 @default.
- W4366990438 cites W2984375168 @default.
- W4366990438 cites W3017093384 @default.
- W4366990438 cites W3092673148 @default.
- W4366990438 cites W3117655623 @default.
- W4366990438 cites W3134302409 @default.
- W4366990438 cites W3195441296 @default.
- W4366990438 cites W3195867506 @default.
- W4366990438 cites W3207632419 @default.
- W4366990438 cites W4210407593 @default.
- W4366990438 cites W4239403073 @default.
- W4366990438 cites W4243722521 @default.
- W4366990438 doi "https://doi.org/10.3390/ph16050642" @default.
- W4366990438 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37242425" @default.
- W4366990438 hasPublicationYear "2023" @default.
- W4366990438 type Work @default.
- W4366990438 citedByCount "0" @default.
- W4366990438 crossrefType "journal-article" @default.
- W4366990438 hasAuthorship W4366990438A5003155041 @default.
- W4366990438 hasAuthorship W4366990438A5009663238 @default.
- W4366990438 hasAuthorship W4366990438A5035081089 @default.
- W4366990438 hasAuthorship W4366990438A5061797555 @default.
- W4366990438 hasAuthorship W4366990438A5064710817 @default.
- W4366990438 hasAuthorship W4366990438A5086352198 @default.
- W4366990438 hasAuthorship W4366990438A5088317787 @default.
- W4366990438 hasBestOaLocation W43669904381 @default.
- W4366990438 hasConcept C105696609 @default.
- W4366990438 hasConcept C1491633281 @default.
- W4366990438 hasConcept C185592680 @default.
- W4366990438 hasConcept C202751555 @default.
- W4366990438 hasConcept C2778227246 @default.
- W4366990438 hasConcept C29537977 @default.
- W4366990438 hasConcept C502942594 @default.
- W4366990438 hasConcept C54355233 @default.
- W4366990438 hasConcept C55493867 @default.
- W4366990438 hasConcept C62112901 @default.
- W4366990438 hasConcept C64241487 @default.
- W4366990438 hasConcept C81885089 @default.
- W4366990438 hasConcept C86803240 @default.
- W4366990438 hasConcept C93304396 @default.
- W4366990438 hasConcept C95444343 @default.
- W4366990438 hasConceptScore W4366990438C105696609 @default.
- W4366990438 hasConceptScore W4366990438C1491633281 @default.
- W4366990438 hasConceptScore W4366990438C185592680 @default.
- W4366990438 hasConceptScore W4366990438C202751555 @default.
- W4366990438 hasConceptScore W4366990438C2778227246 @default.
- W4366990438 hasConceptScore W4366990438C29537977 @default.
- W4366990438 hasConceptScore W4366990438C502942594 @default.
- W4366990438 hasConceptScore W4366990438C54355233 @default.
- W4366990438 hasConceptScore W4366990438C55493867 @default.
- W4366990438 hasConceptScore W4366990438C62112901 @default.
- W4366990438 hasConceptScore W4366990438C64241487 @default.
- W4366990438 hasConceptScore W4366990438C81885089 @default.
- W4366990438 hasConceptScore W4366990438C86803240 @default.
- W4366990438 hasConceptScore W4366990438C93304396 @default.
- W4366990438 hasConceptScore W4366990438C95444343 @default.