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- W4366990735 startingPage "1266" @default.
- W4366990735 abstract "Skin inflammation is a common underlying feature of atopic dermatitis, allergic contact dermatitis and chronic spontaneous urticaria. The pathogenetic mechanisms have not been fully elucidated. The purpose of this study was to examine whether miRNA, by regulating inflammatory mechanisms through the modulation of innate and adaptive immune responses, could play a major role in the pathogenesis of these skin conditions. We conducted a narrative review using the Pubmed and Embase scientific databases and search engines to find the most relevant miRNAs related to the pathophysiology, severity and prognosis of skin conditions. The studies show that miRNAs are involved in the pathogenesis and regulation of atopic dermatitis and can reveal an atopic predisposition or indicate disease severity. In chronic spontaneous urticaria, different miRNAs which are over-expressed during urticaria exacerbations not only play a role in the possible response to therapy or remission, but also serve as a marker of chronic autoimmune urticaria and indicate associations with other autoimmune diseases. In allergic contact dermatitis, miRNAs are upregulated in inflammatory lesions and expressed during the sensitization phase of allergic response. Several miRNAs have been identified as potential biomarkers of these chronic skin conditions, but they are also possible therapeutic targets." @default.
- W4366990735 created "2023-04-27" @default.
- W4366990735 creator A5002730670 @default.
- W4366990735 creator A5026492321 @default.
- W4366990735 creator A5029242382 @default.
- W4366990735 creator A5044722419 @default.
- W4366990735 creator A5052016973 @default.
- W4366990735 creator A5072546849 @default.
- W4366990735 creator A5084226823 @default.
- W4366990735 date "2023-04-24" @default.
- W4366990735 modified "2023-09-26" @default.
- W4366990735 title "miRNAs’ Cross-Involvement in Skin Allergies: A New Horizon for the Pathogenesis, Diagnosis and Therapy of Atopic Dermatitis, Allergic Contact Dermatitis and Chronic Spontaneous Urticaria" @default.
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