Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366990778> ?p ?o ?g. }
- W4366990778 endingPage "587" @default.
- W4366990778 startingPage "587" @default.
- W4366990778 abstract "Visceral adipose tissue (VAT) metabolic fingerprints differ according to body mass index (BMI) and glycemic status. Glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon are gut-associated hormones that play an important role in regulating energy and glucose homeostasis, although their metabolic actions in VAT are still poorly characterized. Our aim was to assess whether GLP-1, GIP and glucagon influence the VAT metabolite profile. To achieve this goal, VAT harvested during elective surgical procedures from individuals (N = 19) with different BMIs and glycemic statuses was stimulated with GLP-1, GIP or glucagon, and culture media was analyzed using proton nuclear magnetic resonance. In the VAT of individuals with obesity and prediabetes, GLP-1 shifted its metabolic profile by increasing alanine and lactate production while also decreasing isoleucine consumption, whereas GIP and glucagon decreased lactate and alanine production and increased pyruvate consumption. In summary, GLP-1, GIP and glucagon were shown to distinctively modulate the VAT metabolic profile depending on the subject's BMI and glycemic status. In VAT from patients with obesity and prediabetes, these hormones induced metabolic shifts toward gluconeogenesis suppression and oxidative phosphorylation enhancement, suggesting an overall improvement in AT mitochondrial function." @default.
- W4366990778 created "2023-04-27" @default.
- W4366990778 creator A5021022567 @default.
- W4366990778 creator A5031304031 @default.
- W4366990778 creator A5035013247 @default.
- W4366990778 creator A5045662876 @default.
- W4366990778 creator A5053362274 @default.
- W4366990778 creator A5070359435 @default.
- W4366990778 creator A5073431252 @default.
- W4366990778 creator A5089614569 @default.
- W4366990778 creator A5090181199 @default.
- W4366990778 date "2023-04-24" @default.
- W4366990778 modified "2023-10-15" @default.
- W4366990778 title "Dysglycemia Shapes Visceral Adipose Tissue’s Response to GIP, GLP-1 and Glucagon in Individuals with Obesity" @default.
- W4366990778 cites W1773084519 @default.
- W4366990778 cites W177682671 @default.
- W4366990778 cites W1946555313 @default.
- W4366990778 cites W1947853286 @default.
- W4366990778 cites W1965225806 @default.
- W4366990778 cites W1966060159 @default.
- W4366990778 cites W1966872601 @default.
- W4366990778 cites W1978037308 @default.
- W4366990778 cites W1978076661 @default.
- W4366990778 cites W1978898901 @default.
- W4366990778 cites W1979592844 @default.
- W4366990778 cites W1995969505 @default.
- W4366990778 cites W1997917664 @default.
- W4366990778 cites W2012037560 @default.
- W4366990778 cites W2046912474 @default.
- W4366990778 cites W2072686461 @default.
- W4366990778 cites W2077281542 @default.
- W4366990778 cites W2081546325 @default.
- W4366990778 cites W2086554547 @default.
- W4366990778 cites W2125591445 @default.
- W4366990778 cites W2136968036 @default.
- W4366990778 cites W2143149722 @default.
- W4366990778 cites W2149528363 @default.
- W4366990778 cites W2151896010 @default.
- W4366990778 cites W2183107372 @default.
- W4366990778 cites W2336446961 @default.
- W4366990778 cites W2345828164 @default.
- W4366990778 cites W2398993912 @default.
- W4366990778 cites W2411975823 @default.
- W4366990778 cites W2568114375 @default.
- W4366990778 cites W2584709305 @default.
- W4366990778 cites W2591832038 @default.
- W4366990778 cites W2612302855 @default.
- W4366990778 cites W2786652970 @default.
- W4366990778 cites W2898180841 @default.
- W4366990778 cites W2902121131 @default.
- W4366990778 cites W2911794357 @default.
- W4366990778 cites W2985753680 @default.
- W4366990778 cites W2990725177 @default.
- W4366990778 cites W2996821007 @default.
- W4366990778 cites W3009231969 @default.
- W4366990778 cites W3087165503 @default.
- W4366990778 cites W3146473190 @default.
- W4366990778 cites W3165762825 @default.
- W4366990778 cites W3173436623 @default.
- W4366990778 cites W3184250385 @default.
- W4366990778 cites W3199734310 @default.
- W4366990778 cites W4224295659 @default.
- W4366990778 cites W4281641083 @default.
- W4366990778 cites W4281934192 @default.
- W4366990778 cites W4292242922 @default.
- W4366990778 cites W4294069033 @default.
- W4366990778 cites W4313529365 @default.
- W4366990778 cites W4316371637 @default.
- W4366990778 doi "https://doi.org/10.3390/metabo13050587" @default.
- W4366990778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37233628" @default.
- W4366990778 hasPublicationYear "2023" @default.
- W4366990778 type Work @default.
- W4366990778 citedByCount "0" @default.
- W4366990778 crossrefType "journal-article" @default.
- W4366990778 hasAuthorship W4366990778A5021022567 @default.
- W4366990778 hasAuthorship W4366990778A5031304031 @default.
- W4366990778 hasAuthorship W4366990778A5035013247 @default.
- W4366990778 hasAuthorship W4366990778A5045662876 @default.
- W4366990778 hasAuthorship W4366990778A5053362274 @default.
- W4366990778 hasAuthorship W4366990778A5070359435 @default.
- W4366990778 hasAuthorship W4366990778A5073431252 @default.
- W4366990778 hasAuthorship W4366990778A5089614569 @default.
- W4366990778 hasAuthorship W4366990778A5090181199 @default.
- W4366990778 hasBestOaLocation W43669907781 @default.
- W4366990778 hasConcept C126322002 @default.
- W4366990778 hasConcept C134018914 @default.
- W4366990778 hasConcept C171089720 @default.
- W4366990778 hasConcept C20904676 @default.
- W4366990778 hasConcept C2776398474 @default.
- W4366990778 hasConcept C2777180221 @default.
- W4366990778 hasConcept C2777391703 @default.
- W4366990778 hasConcept C2778563252 @default.
- W4366990778 hasConcept C2779668308 @default.
- W4366990778 hasConcept C3018667095 @default.
- W4366990778 hasConcept C511355011 @default.
- W4366990778 hasConcept C555293320 @default.
- W4366990778 hasConcept C62231903 @default.
- W4366990778 hasConcept C71315377 @default.