Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366990992> ?p ?o ?g. }
- W4366990992 endingPage "807" @default.
- W4366990992 startingPage "807" @default.
- W4366990992 abstract "New N-acyl thiourea derivatives with heterocyclic rings have been synthesized by first obtaining isothiocyanate, which further reacted with a heterocyclic amine, characterized by (FT-IR, NMR spectroscopy and FT-ICR) and tested for their in vitro antimicrobial, anti-biofilm and antioxidant activities to obtain a drug candidate in a lead-optimization process. From the tested compounds, those bearing benzothiazole (1b) and 6-methylpyridine (1d) moieties revealed anti-biofilm activity against E. coli ATCC 25922 at MBIC values of 625 µg/mL. Compound 1d exhibited the highest antioxidant capacity (~43%) in the in vitro assay using 1,1-diphenyl-2-picrylhydrazyl (DPPH). Considering the in vitro results, the highest anti-biofilm and antioxidant activities were obtained for compound 1d. Therefore, a reversed-phase high-performance liquid chromatography (RP-HPLC) method has been optimized and validated for the quantitative determination of compound 1d. The detection and quantitation limits were 0.0174 μg/mL and 0.0521 μg/mL, respectively. The R2 correlation coefficient of the LOQ and linearity curves were greater than 0.99, over the concentration range of 0.05 μg/mL-40 μg/mL. The precision and accuracy of the analytical method were within 98-102%, confirming that the method is suitable for the quantitative determination of compound 1d in routine quality control analyses. Evaluating the results, the promising potential of the new N-acyl thiourea derivatives bearing 6-methylpyridine moiety will be further investigated for developing agents with anti-biofilm and antioxidant activities." @default.
- W4366990992 created "2023-04-27" @default.
- W4366990992 creator A5001059217 @default.
- W4366990992 creator A5006900044 @default.
- W4366990992 creator A5037454823 @default.
- W4366990992 creator A5038378457 @default.
- W4366990992 creator A5044856699 @default.
- W4366990992 creator A5046184530 @default.
- W4366990992 creator A5047432685 @default.
- W4366990992 creator A5058777606 @default.
- W4366990992 creator A5066094435 @default.
- W4366990992 creator A5073300293 @default.
- W4366990992 creator A5085907216 @default.
- W4366990992 creator A5089257773 @default.
- W4366990992 creator A5089830132 @default.
- W4366990992 date "2023-04-25" @default.
- W4366990992 modified "2023-10-18" @default.
- W4366990992 title "New N-acyl Thiourea Derivatives: Synthesis, Standardized Quantification Method and In Vitro Evaluation of Potential Biological Activities" @default.
- W4366990992 cites W165982970 @default.
- W4366990992 cites W1967756480 @default.
- W4366990992 cites W1970082148 @default.
- W4366990992 cites W1971702116 @default.
- W4366990992 cites W1987885980 @default.
- W4366990992 cites W2002134430 @default.
- W4366990992 cites W2014837393 @default.
- W4366990992 cites W2015528579 @default.
- W4366990992 cites W2020600827 @default.
- W4366990992 cites W2021720665 @default.
- W4366990992 cites W2028535303 @default.
- W4366990992 cites W2030487700 @default.
- W4366990992 cites W2031488922 @default.
- W4366990992 cites W2031612079 @default.
- W4366990992 cites W2033600360 @default.
- W4366990992 cites W2038466121 @default.
- W4366990992 cites W2045694872 @default.
- W4366990992 cites W2072348601 @default.
- W4366990992 cites W2073745821 @default.
- W4366990992 cites W2103658594 @default.
- W4366990992 cites W2117057646 @default.
- W4366990992 cites W2148956232 @default.
- W4366990992 cites W2169035549 @default.
- W4366990992 cites W2319541881 @default.
- W4366990992 cites W2327975263 @default.
- W4366990992 cites W2329479313 @default.
- W4366990992 cites W2346194828 @default.
- W4366990992 cites W2556809094 @default.
- W4366990992 cites W2571362529 @default.
- W4366990992 cites W2582100724 @default.
- W4366990992 cites W2588127585 @default.
- W4366990992 cites W2604610052 @default.
- W4366990992 cites W2787775773 @default.
- W4366990992 cites W2802842185 @default.
- W4366990992 cites W2810495156 @default.
- W4366990992 cites W2889239202 @default.
- W4366990992 cites W2908390120 @default.
- W4366990992 cites W2946458716 @default.
- W4366990992 cites W2951785431 @default.
- W4366990992 cites W2969242303 @default.
- W4366990992 cites W2985668493 @default.
- W4366990992 cites W3011892366 @default.
- W4366990992 cites W3013073252 @default.
- W4366990992 cites W3014009822 @default.
- W4366990992 cites W3019550944 @default.
- W4366990992 cites W3023780189 @default.
- W4366990992 cites W3025407852 @default.
- W4366990992 cites W3041386180 @default.
- W4366990992 cites W3049266455 @default.
- W4366990992 cites W3090603017 @default.
- W4366990992 cites W3165414691 @default.
- W4366990992 cites W3183299155 @default.
- W4366990992 cites W3191206647 @default.
- W4366990992 cites W3209484937 @default.
- W4366990992 cites W3214586897 @default.
- W4366990992 cites W4205765055 @default.
- W4366990992 cites W4210886182 @default.
- W4366990992 cites W4244846039 @default.
- W4366990992 cites W4280614662 @default.
- W4366990992 cites W4283364338 @default.
- W4366990992 cites W4283768275 @default.
- W4366990992 cites W4285409455 @default.
- W4366990992 cites W4290636015 @default.
- W4366990992 cites W808835750 @default.
- W4366990992 doi "https://doi.org/10.3390/antibiotics12050807" @default.
- W4366990992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37237710" @default.
- W4366990992 hasPublicationYear "2023" @default.
- W4366990992 type Work @default.
- W4366990992 citedByCount "0" @default.
- W4366990992 crossrefType "journal-article" @default.
- W4366990992 hasAuthorship W4366990992A5001059217 @default.
- W4366990992 hasAuthorship W4366990992A5006900044 @default.
- W4366990992 hasAuthorship W4366990992A5037454823 @default.
- W4366990992 hasAuthorship W4366990992A5038378457 @default.
- W4366990992 hasAuthorship W4366990992A5044856699 @default.
- W4366990992 hasAuthorship W4366990992A5046184530 @default.
- W4366990992 hasAuthorship W4366990992A5047432685 @default.
- W4366990992 hasAuthorship W4366990992A5058777606 @default.
- W4366990992 hasAuthorship W4366990992A5066094435 @default.
- W4366990992 hasAuthorship W4366990992A5073300293 @default.