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- W4366991132 startingPage "7809" @default.
- W4366991132 abstract "Sarcopenia, an illness condition usually characterized by a loss of skeletal muscle mass and muscle strength or function, is often associated with neurodegenerative diseases, such as Alzheimer’s disease (AD), a common type of dementia, leading to memory loss and other cognitive impairment. However, the underlying mechanisms for their associations and relationships are less well understood. The App, a Mendelian gene for early-onset AD, encodes amyloid precursor protein (APP), a transmembrane protein enriched at both the neuromuscular junction (NMJ) and synapses in the central nervous system (CNS). Here, in this review, we highlight APP and its family members’ physiological functions and Swedish mutant APP (APPswe)’s pathological roles in muscles and NMJ. Understanding APP’s pathophysiological functions in muscles and NMJ is likely to uncover insights not only into neuromuscular diseases but also AD. We summarize key findings from the burgeoning literature, which may open new avenues to investigate the link between muscle cells and brain cells in the development and progression of AD and sarcopenia." @default.
- W4366991132 created "2023-04-27" @default.
- W4366991132 creator A5024851042 @default.
- W4366991132 creator A5037736308 @default.
- W4366991132 creator A5038135370 @default.
- W4366991132 creator A5041349623 @default.
- W4366991132 creator A5083041006 @default.
- W4366991132 date "2023-04-25" @default.
- W4366991132 modified "2023-10-17" @default.
- W4366991132 title "APP in the Neuromuscular Junction for the Development of Sarcopenia and Alzheimer’s Disease" @default.
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