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- W4366991141 abstract "This article estimates the disease burden of 5q-SMA in Colombia by using the disability-adjusted life years (DALYs) metric.Epidemiological data were obtained from local databases and medical literature and were adjusted in the DisMod II tool. DALYs were obtained by adding years of life lost due to premature death (YLL) and years lived with disability (YLD).The modeled prevalence of 5q-SMA in Colombia was 0.74 per 100,000 population. The fatality rate for all types was 14.1%. The disease burden of 5q-SMA was estimated at 4,421 DALYs (8.6 DALYs/100,000), corresponding to 4,214 (95.3%) YLLs and 207 (4.7%) YLDs. Most of the DALYs were accounted in the 2-17 age group. Of the total burden, 78% correspond to SMA type 1, 18% to type 2, and 4% to type 3.Although 5q-SMA is a rare disease, it is linked to a significant disease burden due to premature mortality and severe sequelae. The estimates shown in this article are important inputs to inform public policy decisions on how to ensure adequate health service provision for patients with 5q-SMA." @default.
- W4366991141 created "2023-04-27" @default.
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- W4366991141 date "2023-04-28" @default.
- W4366991141 modified "2023-10-17" @default.
- W4366991141 title "Burden of disease of spinal muscular atrophy linked to chromosome 5q (5q-SMA) in Colombia" @default.
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- W4366991141 doi "https://doi.org/10.1080/14737167.2023.2206569" @default.
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