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- W4366991204 abstract "Influenza virus poses an ongoing human health threat with pandemic potential. Due to mutations in circulating strains, formulating effective vaccines remains a challenge. The use of computationally optimized broadly reactive antigen (COBRA) hemagglutinin (HA) proteins is a promising vaccine strategy to protect against a wide range of current and future influenza viruses. Though effective in preclinical studies, the mechanistic basis driving the broad reactivity of COBRA proteins remains to be elucidated. Here, we report the crystal structure of the COBRA HA termed P1 and identify antigenic and glycosylation properties that contribute to its immunogenicity. We further report the cryo-EM structure of the P1-elicited broadly neutralizing antibody 1F8 bound to COBRA P1, revealing 1F8 to recognize an atypical receptor binding site epitope via an unexpected mode of binding." @default.
- W4366991204 created "2023-04-27" @default.
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- W4366991204 date "2023-04-25" @default.
- W4366991204 modified "2023-10-16" @default.
- W4366991204 title "Structural insights into the broad protection against H1 influenza viruses by a computationally optimized hemagglutinin vaccine" @default.
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- W4366991204 cites W2055817672 @default.
- W4366991204 cites W2061221862 @default.
- W4366991204 cites W2062740562 @default.
- W4366991204 cites W2071200955 @default.
- W4366991204 cites W2071644795 @default.
- W4366991204 cites W2074712481 @default.
- W4366991204 cites W2076449818 @default.
- W4366991204 cites W2077219861 @default.
- W4366991204 cites W2078448530 @default.
- W4366991204 cites W2101375662 @default.
- W4366991204 cites W2104391453 @default.
- W4366991204 cites W2108573701 @default.
- W4366991204 cites W2108921801 @default.
- W4366991204 cites W2110808180 @default.
- W4366991204 cites W2114923690 @default.
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- W4366991204 cites W2129138941 @default.
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- W4366991204 cites W2150661836 @default.
- W4366991204 cites W2152617913 @default.
- W4366991204 cites W2153021768 @default.
- W4366991204 cites W2154197653 @default.
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- W4366991204 cites W2163341755 @default.
- W4366991204 cites W2164807254 @default.
- W4366991204 cites W2168974130 @default.
- W4366991204 cites W2339357145 @default.
- W4366991204 cites W2412035302 @default.
- W4366991204 cites W2525128349 @default.
- W4366991204 cites W2580666741 @default.
- W4366991204 cites W2587625522 @default.
- W4366991204 cites W2734356283 @default.
- W4366991204 cites W2761773114 @default.
- W4366991204 cites W2765322245 @default.
- W4366991204 cites W2768157147 @default.
- W4366991204 cites W2782903037 @default.
- W4366991204 cites W2786390877 @default.
- W4366991204 cites W2790722089 @default.
- W4366991204 cites W2791670278 @default.
- W4366991204 cites W2793311671 @default.
- W4366991204 cites W2889331543 @default.
- W4366991204 cites W2923686438 @default.
- W4366991204 cites W2938574745 @default.
- W4366991204 cites W2940763506 @default.
- W4366991204 cites W2950967305 @default.
- W4366991204 cites W2951570670 @default.
- W4366991204 cites W2971065998 @default.
- W4366991204 cites W2973457155 @default.
- W4366991204 cites W2985720349 @default.
- W4366991204 cites W2987120839 @default.
- W4366991204 cites W2992070729 @default.
- W4366991204 cites W2994985498 @default.
- W4366991204 cites W3080190993 @default.
- W4366991204 cites W3107802672 @default.
- W4366991204 cites W3111038302 @default.
- W4366991204 cites W3111233796 @default.
- W4366991204 cites W3137796232 @default.
- W4366991204 cites W3150182460 @default.
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- W4366991204 cites W3164478716 @default.
- W4366991204 cites W3205303139 @default.
- W4366991204 cites W385144914 @default.
- W4366991204 cites W4200403158 @default.
- W4366991204 cites W4230654908 @default.
- W4366991204 cites W4282918616 @default.
- W4366991204 cites W4289525125 @default.
- W4366991204 cites W4294316461 @default.
- W4366991204 doi "https://doi.org/10.1038/s42003-023-04793-3" @default.
- W4366991204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37185989" @default.
- W4366991204 hasPublicationYear "2023" @default.
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