Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366991550> ?p ?o ?g. }
- W4366991550 abstract "The liver plays a critical role in sepsis, which is a serious worldwide public health problem. A novel mechanism of controlled cell death called ferroptosis has recently been described. Disrupted redox equilibrium, excessive iron, and enhanced lipid peroxidation are key features of ferroptosis. It is unknown how ferroptosis affects liver damage caused by sepsis. In the present study, we aimed to elucidate the pathways and explore the impact of artemisitene (ATT) on ferroptosis in sepsis-induced liver injury. Our findings demonstrated that ATT significantly decreased liver damage and ferroptotic characteristics. Additionally, ATT significantly reduced the expression of the nuclear factor-κB (NF-κB) subunit to reduce LPS-induced hepatic oxidative stress and inflammation and upregulated the expression of nuclear factor-erythroid 2 (NF-E2)-related factor 2 (Nrf2) and its downstream protein heme oxygenase 1 (HO-1). This may offer a new strategy for preventing LPS-induced hepatic injury." @default.
- W4366991550 created "2023-04-27" @default.
- W4366991550 creator A5024821332 @default.
- W4366991550 creator A5042056497 @default.
- W4366991550 creator A5056092145 @default.
- W4366991550 creator A5058871962 @default.
- W4366991550 date "2023-04-25" @default.
- W4366991550 modified "2023-10-18" @default.
- W4366991550 title "Artemisitene Alters LPS-Induced Oxidative stress, inflammation and Ferroptosis in Liver Through Nrf2/HO-1 and NF-kB Pathway" @default.
- W4366991550 cites W1986111317 @default.
- W4366991550 cites W1997183854 @default.
- W4366991550 cites W2002490399 @default.
- W4366991550 cites W2027447934 @default.
- W4366991550 cites W2122142133 @default.
- W4366991550 cites W2318098379 @default.
- W4366991550 cites W2470889344 @default.
- W4366991550 cites W2548618596 @default.
- W4366991550 cites W2557362198 @default.
- W4366991550 cites W2567040191 @default.
- W4366991550 cites W2616772553 @default.
- W4366991550 cites W2761040354 @default.
- W4366991550 cites W2762087180 @default.
- W4366991550 cites W2804585100 @default.
- W4366991550 cites W2890668604 @default.
- W4366991550 cites W2897829100 @default.
- W4366991550 cites W2898334602 @default.
- W4366991550 cites W2909817598 @default.
- W4366991550 cites W2916144846 @default.
- W4366991550 cites W2979799294 @default.
- W4366991550 cites W2991502704 @default.
- W4366991550 cites W3003960907 @default.
- W4366991550 cites W3017999288 @default.
- W4366991550 cites W3020890805 @default.
- W4366991550 cites W3025129146 @default.
- W4366991550 cites W3038503389 @default.
- W4366991550 cites W3081112033 @default.
- W4366991550 cites W3090062091 @default.
- W4366991550 cites W3204982646 @default.
- W4366991550 cites W4220781666 @default.
- W4366991550 cites W4223612851 @default.
- W4366991550 cites W4226021036 @default.
- W4366991550 cites W4293004208 @default.
- W4366991550 cites W4297348305 @default.
- W4366991550 doi "https://doi.org/10.3389/fphar.2023.1177542" @default.
- W4366991550 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37180725" @default.
- W4366991550 hasPublicationYear "2023" @default.
- W4366991550 type Work @default.
- W4366991550 citedByCount "1" @default.
- W4366991550 crossrefType "journal-article" @default.
- W4366991550 hasAuthorship W4366991550A5024821332 @default.
- W4366991550 hasAuthorship W4366991550A5042056497 @default.
- W4366991550 hasAuthorship W4366991550A5056092145 @default.
- W4366991550 hasAuthorship W4366991550A5058871962 @default.
- W4366991550 hasBestOaLocation W43669915501 @default.
- W4366991550 hasConcept C104317684 @default.
- W4366991550 hasConcept C123298856 @default.
- W4366991550 hasConcept C127561419 @default.
- W4366991550 hasConcept C181199279 @default.
- W4366991550 hasConcept C185592680 @default.
- W4366991550 hasConcept C203014093 @default.
- W4366991550 hasConcept C2776151105 @default.
- W4366991550 hasConcept C2776217839 @default.
- W4366991550 hasConcept C2776637226 @default.
- W4366991550 hasConcept C2776914184 @default.
- W4366991550 hasConcept C2777730290 @default.
- W4366991550 hasConcept C2778384902 @default.
- W4366991550 hasConcept C2779219270 @default.
- W4366991550 hasConcept C2780829032 @default.
- W4366991550 hasConcept C48349386 @default.
- W4366991550 hasConcept C502942594 @default.
- W4366991550 hasConcept C55493867 @default.
- W4366991550 hasConcept C62478195 @default.
- W4366991550 hasConcept C71924100 @default.
- W4366991550 hasConcept C86339819 @default.
- W4366991550 hasConcept C86803240 @default.
- W4366991550 hasConcept C95444343 @default.
- W4366991550 hasConcept C98274493 @default.
- W4366991550 hasConceptScore W4366991550C104317684 @default.
- W4366991550 hasConceptScore W4366991550C123298856 @default.
- W4366991550 hasConceptScore W4366991550C127561419 @default.
- W4366991550 hasConceptScore W4366991550C181199279 @default.
- W4366991550 hasConceptScore W4366991550C185592680 @default.
- W4366991550 hasConceptScore W4366991550C203014093 @default.
- W4366991550 hasConceptScore W4366991550C2776151105 @default.
- W4366991550 hasConceptScore W4366991550C2776217839 @default.
- W4366991550 hasConceptScore W4366991550C2776637226 @default.
- W4366991550 hasConceptScore W4366991550C2776914184 @default.
- W4366991550 hasConceptScore W4366991550C2777730290 @default.
- W4366991550 hasConceptScore W4366991550C2778384902 @default.
- W4366991550 hasConceptScore W4366991550C2779219270 @default.
- W4366991550 hasConceptScore W4366991550C2780829032 @default.
- W4366991550 hasConceptScore W4366991550C48349386 @default.
- W4366991550 hasConceptScore W4366991550C502942594 @default.
- W4366991550 hasConceptScore W4366991550C55493867 @default.
- W4366991550 hasConceptScore W4366991550C62478195 @default.
- W4366991550 hasConceptScore W4366991550C71924100 @default.
- W4366991550 hasConceptScore W4366991550C86339819 @default.
- W4366991550 hasConceptScore W4366991550C86803240 @default.
- W4366991550 hasConceptScore W4366991550C95444343 @default.
- W4366991550 hasConceptScore W4366991550C98274493 @default.