Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366991697> ?p ?o ?g. }
- W4366991697 abstract "Asians often face the problems of clopidogrel resistance and East Asian paradox. This study aimed to evaluate the effects of P2Y12 inhibitors, including low-dose prasugrel 2.5 mg, on the P2Y12 reaction unit (PRU) in the chronic phase after percutaneous coronary intervention (PCI).A total of 348 patients were studied. PRU was measured 6-12 months after PCI and subsequently, 6 months later using a P2Y12 assay, respectively. This study evaluated the proportion of bleeding risk (PRU ≤ 85) and ischemic risk (PRU ≥ 239) as primary endpoints, and the prediction of bleeding risk and ischemic risk using multivariable logistic regression analysis.At baseline, 136 patients (39%) received prasugrel 3.75 mg, 48 patients (14%) received prasugrel 2.5 mg, and 164 patients (47%) received clopidogrel 75 mg. Clopidogrel 75 mg had a significantly higher proportion of ischemic risk within one year after PCI than the other groups, and was an independent predictor for ischemic risk with reference of prasugrel 3.75 mg. In addition, switching from clopidogrel 75 mg to prasugrel 2.5 mg significantly lowered and aggregated the PRU value. Whereas, dose reduction of prasugrel had a significantly lower proportion of bleeding risk over one year after PCI than the continuation of prasugrel 3.75 mg, and was an independent predictor for bleeding risk with reference of continuation of prasugrel 3.75 mg.Prasugrel 2.5 mg has a lower ischemic risk and a more stable PRU value compared with clopidogrel treatment. Prasugrel also contributes to a decline in bleeding risk with concomitant dose reduction.University Hospital Medical Information Network (UMIN), ID: UMIN000029541, Date: October 16, 2017 ( https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000033395 )." @default.
- W4366991697 created "2023-04-27" @default.
- W4366991697 creator A5000117746 @default.
- W4366991697 creator A5003746090 @default.
- W4366991697 creator A5005952657 @default.
- W4366991697 creator A5011879930 @default.
- W4366991697 creator A5025864326 @default.
- W4366991697 creator A5032939425 @default.
- W4366991697 creator A5033092933 @default.
- W4366991697 creator A5039065380 @default.
- W4366991697 creator A5042369450 @default.
- W4366991697 creator A5055337893 @default.
- W4366991697 creator A5057752010 @default.
- W4366991697 creator A5058793966 @default.
- W4366991697 creator A5068670568 @default.
- W4366991697 creator A5071868929 @default.
- W4366991697 creator A5074027680 @default.
- W4366991697 creator A5076375061 @default.
- W4366991697 creator A5089079603 @default.
- W4366991697 creator A5089383750 @default.
- W4366991697 date "2023-04-25" @default.
- W4366991697 modified "2023-10-18" @default.
- W4366991697 title "Impact of Low-Dose Prasugrel on Platelet Reactivity in Chronic Phase of Post-Percutaneous Coronary Intervention (CHAPERON): a Prospective Cohort Study" @default.
- W4366991697 cites W1484112502 @default.
- W4366991697 cites W1923386888 @default.
- W4366991697 cites W1965018592 @default.
- W4366991697 cites W1978212707 @default.
- W4366991697 cites W2010297819 @default.
- W4366991697 cites W2016760364 @default.
- W4366991697 cites W2030244779 @default.
- W4366991697 cites W2032518559 @default.
- W4366991697 cites W2044837224 @default.
- W4366991697 cites W2057681387 @default.
- W4366991697 cites W2066618227 @default.
- W4366991697 cites W2068236509 @default.
- W4366991697 cites W2078009181 @default.
- W4366991697 cites W2097803937 @default.
- W4366991697 cites W2103798306 @default.
- W4366991697 cites W2103798714 @default.
- W4366991697 cites W2105210342 @default.
- W4366991697 cites W2122779695 @default.
- W4366991697 cites W2128228188 @default.
- W4366991697 cites W2145425156 @default.
- W4366991697 cites W2152189242 @default.
- W4366991697 cites W2169387542 @default.
- W4366991697 cites W2327850977 @default.
- W4366991697 cites W2614154720 @default.
- W4366991697 cites W2781254208 @default.
- W4366991697 cites W27822908 @default.
- W4366991697 cites W2804251795 @default.
- W4366991697 cites W2811381150 @default.
- W4366991697 cites W2953479758 @default.
- W4366991697 cites W2955952534 @default.
- W4366991697 cites W2966611464 @default.
- W4366991697 cites W2973068166 @default.
- W4366991697 cites W3012340745 @default.
- W4366991697 cites W3082881918 @default.
- W4366991697 cites W3181861221 @default.
- W4366991697 cites W65377277 @default.
- W4366991697 cites W72869980 @default.
- W4366991697 doi "https://doi.org/10.1007/s10557-023-07454-z" @default.
- W4366991697 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37097381" @default.
- W4366991697 hasPublicationYear "2023" @default.
- W4366991697 type Work @default.
- W4366991697 citedByCount "0" @default.
- W4366991697 crossrefType "journal-article" @default.
- W4366991697 hasAuthorship W4366991697A5000117746 @default.
- W4366991697 hasAuthorship W4366991697A5003746090 @default.
- W4366991697 hasAuthorship W4366991697A5005952657 @default.
- W4366991697 hasAuthorship W4366991697A5011879930 @default.
- W4366991697 hasAuthorship W4366991697A5025864326 @default.
- W4366991697 hasAuthorship W4366991697A5032939425 @default.
- W4366991697 hasAuthorship W4366991697A5033092933 @default.
- W4366991697 hasAuthorship W4366991697A5039065380 @default.
- W4366991697 hasAuthorship W4366991697A5042369450 @default.
- W4366991697 hasAuthorship W4366991697A5055337893 @default.
- W4366991697 hasAuthorship W4366991697A5057752010 @default.
- W4366991697 hasAuthorship W4366991697A5058793966 @default.
- W4366991697 hasAuthorship W4366991697A5068670568 @default.
- W4366991697 hasAuthorship W4366991697A5071868929 @default.
- W4366991697 hasAuthorship W4366991697A5074027680 @default.
- W4366991697 hasAuthorship W4366991697A5076375061 @default.
- W4366991697 hasAuthorship W4366991697A5089079603 @default.
- W4366991697 hasAuthorship W4366991697A5089383750 @default.
- W4366991697 hasBestOaLocation W43669916972 @default.
- W4366991697 hasConcept C126322002 @default.
- W4366991697 hasConcept C164705383 @default.
- W4366991697 hasConcept C2777028646 @default.
- W4366991697 hasConcept C2777849778 @default.
- W4366991697 hasConcept C2780400711 @default.
- W4366991697 hasConcept C35294091 @default.
- W4366991697 hasConcept C45393284 @default.
- W4366991697 hasConcept C49059817 @default.
- W4366991697 hasConcept C500558357 @default.
- W4366991697 hasConcept C71924100 @default.
- W4366991697 hasConceptScore W4366991697C126322002 @default.
- W4366991697 hasConceptScore W4366991697C164705383 @default.
- W4366991697 hasConceptScore W4366991697C2777028646 @default.
- W4366991697 hasConceptScore W4366991697C2777849778 @default.
- W4366991697 hasConceptScore W4366991697C2780400711 @default.