Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366991790> ?p ?o ?g. }
- W4366991790 abstract "Control of Mycobacterium tuberculosis (Mtb) infection requires generation of T cells that migrate to granulomas, complex immune structures surrounding sites of bacterial replication. Here we compared the gene expression profiles of T cells in pulmonary granulomas, bronchoalveolar lavage, and blood of Mtb-infected rhesus macaques to identify granuloma-enriched T cell genes. TNFRSF8/CD30 was among the top genes upregulated in both CD4 and CD8 T cells from granulomas. In mice, CD30 expression on CD4 T cells is required for survival of Mtb infection, and there is no major role for CD30 in protection by other cell types. Transcriptomic comparison of WT and CD30-/- CD4 T cells from the lungs of Mtb-infected mixed bone marrow chimeric mice showed that CD30 directly promotes CD4 T cell differentiation and the expression of multiple effector molecules. These results demonstrate that the CD30 co-stimulatory axis is highly upregulated on granuloma T cells and is critical for protective T cell responses against Mtb infection." @default.
- W4366991790 created "2023-04-27" @default.
- W4366991790 creator A5005138562 @default.
- W4366991790 creator A5011849894 @default.
- W4366991790 creator A5018818205 @default.
- W4366991790 creator A5027659864 @default.
- W4366991790 creator A5049966762 @default.
- W4366991790 creator A5061592542 @default.
- W4366991790 creator A5077532966 @default.
- W4366991790 creator A5078659085 @default.
- W4366991790 date "2023-04-25" @default.
- W4366991790 modified "2023-09-29" @default.
- W4366991790 title "CD30 co-stimulation drives differentiation of protective T cells during <i>Mycobacterium tuberculosis</i> infection" @default.
- W4366991790 cites W1624592617 @default.
- W4366991790 cites W2027189611 @default.
- W4366991790 cites W2059359466 @default.
- W4366991790 cites W2083578218 @default.
- W4366991790 cites W2112541034 @default.
- W4366991790 cites W2116794323 @default.
- W4366991790 cites W2123093300 @default.
- W4366991790 cites W2130410032 @default.
- W4366991790 cites W2130440043 @default.
- W4366991790 cites W2146612401 @default.
- W4366991790 cites W2152940310 @default.
- W4366991790 cites W2158101883 @default.
- W4366991790 cites W2170320980 @default.
- W4366991790 cites W2269375097 @default.
- W4366991790 cites W2515214907 @default.
- W4366991790 cites W2520295082 @default.
- W4366991790 cites W2527697187 @default.
- W4366991790 cites W2602299919 @default.
- W4366991790 cites W2622444804 @default.
- W4366991790 cites W2737721014 @default.
- W4366991790 cites W2744827189 @default.
- W4366991790 cites W2766533730 @default.
- W4366991790 cites W2783990226 @default.
- W4366991790 cites W2793679146 @default.
- W4366991790 cites W2795199576 @default.
- W4366991790 cites W2803146240 @default.
- W4366991790 cites W2804116873 @default.
- W4366991790 cites W2872754763 @default.
- W4366991790 cites W2890141820 @default.
- W4366991790 cites W2890334235 @default.
- W4366991790 cites W2892215888 @default.
- W4366991790 cites W2894391687 @default.
- W4366991790 cites W2900675224 @default.
- W4366991790 cites W2910312028 @default.
- W4366991790 cites W2925630840 @default.
- W4366991790 cites W2938499334 @default.
- W4366991790 cites W2945883683 @default.
- W4366991790 cites W2996452081 @default.
- W4366991790 cites W2997968756 @default.
- W4366991790 cites W3043398367 @default.
- W4366991790 cites W3090480693 @default.
- W4366991790 cites W3092868538 @default.
- W4366991790 cites W3096604220 @default.
- W4366991790 cites W3123410876 @default.
- W4366991790 cites W3126394803 @default.
- W4366991790 cites W3128988784 @default.
- W4366991790 cites W3133633037 @default.
- W4366991790 cites W3154015170 @default.
- W4366991790 cites W3164808722 @default.
- W4366991790 cites W3183617093 @default.
- W4366991790 cites W3183788950 @default.
- W4366991790 cites W4206561210 @default.
- W4366991790 cites W4210889740 @default.
- W4366991790 cites W4214499529 @default.
- W4366991790 cites W4225137247 @default.
- W4366991790 cites W4225697612 @default.
- W4366991790 cites W4281632681 @default.
- W4366991790 cites W4287510469 @default.
- W4366991790 doi "https://doi.org/10.1084/jem.20222090" @default.
- W4366991790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37097292" @default.
- W4366991790 hasPublicationYear "2023" @default.
- W4366991790 type Work @default.
- W4366991790 citedByCount "1" @default.
- W4366991790 countsByYear W43669917902023 @default.
- W4366991790 crossrefType "journal-article" @default.
- W4366991790 hasAuthorship W4366991790A5005138562 @default.
- W4366991790 hasAuthorship W4366991790A5011849894 @default.
- W4366991790 hasAuthorship W4366991790A5018818205 @default.
- W4366991790 hasAuthorship W4366991790A5027659864 @default.
- W4366991790 hasAuthorship W4366991790A5049966762 @default.
- W4366991790 hasAuthorship W4366991790A5061592542 @default.
- W4366991790 hasAuthorship W4366991790A5077532966 @default.
- W4366991790 hasAuthorship W4366991790A5078659085 @default.
- W4366991790 hasConcept C142724271 @default.
- W4366991790 hasConcept C154317977 @default.
- W4366991790 hasConcept C167672396 @default.
- W4366991790 hasConcept C202751555 @default.
- W4366991790 hasConcept C203014093 @default.
- W4366991790 hasConcept C2776090121 @default.
- W4366991790 hasConcept C2777975735 @default.
- W4366991790 hasConcept C2780140890 @default.
- W4366991790 hasConcept C2781069245 @default.
- W4366991790 hasConcept C55493867 @default.
- W4366991790 hasConcept C71924100 @default.
- W4366991790 hasConcept C86803240 @default.
- W4366991790 hasConcept C8891405 @default.
- W4366991790 hasConceptScore W4366991790C142724271 @default.